Effect of vitamin D<sub>3</sub> overdose and calcium
               supplementation in experimental nephrolithiasis model

Ramos, Maria Fátima de Paula; Santana, Luciane Gomes de; Rasvickas, Clara Versolato; Teixeira, Vicente de Paulo Castro; Schor, Nestor

doi:10.5935/0101-2800.20140022

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Brazilian Journal of Nephrology

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Original Articles • J Bras Nefrol 36 (2) • Apr-Jun 2014 • https://doi.org/10.5935/0101-2800.20140022 copy

Effect of vitamin D₃ overdose and calcium supplementation in experimental nephrolithiasis model

Authorship SCIMAGO INSTITUTIONS RANKINGS

Introduction:

There is little information in the literature relating supplementary oral usage of vitamin D and calcium to the development of kidney stones.

Objective:

To evaluate the effect of high dose, 200 IU of vitamin D₃ (V) with calcium supplementation (Ca).

Methods:

Experimental model consists of insertion of pellets into the bladder of rats. V was administered for 30 days with or without Ca. The rats were divided in 6 groups: 1. Sham, 2. Pellets control; 3. V control; 4. Pellets + V; 5. Pellets + Ca and 6. Pellets + Ca + V.

Results:

50% and 17% decreases bladder stones formation in groups 5 and 6, p < 0.005 comparing with the group 2 were observed. There was no hypercalcemia or hypercalciuria in all groups. We observed a significant decrease in calciuria in group 6 (p = 0.03).

Conclusion:

The administration of the V associated with Ca significantly decreased the formation of stones and caused a significant reduction in urinary calcium, suggesting a protection in the lithogenic pathophysiology.

25-hydroxyvitamin D 2; nephrolithiasis; vitamin D; vitamin D deficiency

	Calcemia start	Calcemia end	Student t-test	Calciuria mg/day start	Calciuria mg/day end	Student t-test
1. Sham	9.82 ± 0.45	9.65 ± 0.57	p = 0.64	0.33 ± 0.04	0.38 ± 0.07	p = 0.17
2. CP	9.15 ± 0.37	9.57 ± 0.42	p = 0.83	0.42 ± 0.11	0.36 ± 0.07	p = 0.10
3. CV	9.50 ± 0.24	9.93 ± 1.23	p = 0.42	0.30 ± 0.18	0.34 ± 0.14	p = 0.68
4. PV	9.93 ± 0.61	9.57 ± 0.34	p = 0.23	0.33 ± 0.28	0.47 ± 0.28	p = 0.07
5. PCa	9.90 ± 0.39	10.13 ± 0.33	p = 0.20	0.45 ± 0.13	0.37 ± 0.15	p = 0.14
6. PCaV	10.15 ± 0.30	10.00 ± 0.43	p = 0.45	0.40 ± 0.13	0.21 ± 0.21*	*p = 0.03

	Mg plasma start	Mg plasma end	Student t-test	Mg urine mg/day start	Mg urine mg/day end	Student t-test
1 Sham	2.13 ± 0.19	2.72 ± 0.17	p = 0.10	1.82 ± 0.82	3.44 ± 0.81	p =	0.11
2. CP	2.53 ± 0.16	2.38 ± 0.16	p = 0.19	1.77 ± 1.27	2.31 ± 1.78	p =	0.55
3. CV	2.48 ± 0.29	2.67 ± 0.80	p = 0.63	1.70 ± 1.03	1.99 ± 1.40	p =	0.75
4. PV	2.55 ± 0.40	2.37 ± 0.12	p = 0.28	1.28 ± 0.65	2.63 ± 1.43	p =	0.11
5. PCa	2.31 ± 0.10	2.57 ± 0.31	p = 0.10	2.81 ± 1.38	2.87 ± 1.73	p =	0.82
6. PCaV	2.27 ± 0.27	2.47 ± 0.27	p = 0.19	1.64 ± 1.63	1.70 ± 1.51	p =	0.83

Sham i	Sham f	CV i	CV f	CP i	CP f	PV i	PV f	PCa i	PCa f	PCaVit i	PCaVit f
1.29	1.68	0.96	1.32	0.97	1.43	1.19	1.92	1.43	1.11	1.73	1.63
1.35	1.29	0.77	1.22	1.46	1.19	1.16	1.36	1.00	0.82	1.20	1.26
1.29	1.22	0.85	1.12	0.91	0.92	1.64	1.61	0.98	1.20	1.08	0.91
1.42	1.28	1.60	1.30	0.91	1.76	1.86	1.45	1.04	1.87	1.03	0.82
1.62	1.42	1.50	1.58	1.72	1.53	1.25	1.10	1.31	1.05	1.45	1.42
1.41	1.72	1.21	1.06	0.89	1.26	1.10	1.23	1.68	0.83	1.86	1.81
	p = 0.72		p = 0.37		p = 0.29		p = 0.64		p = 0.70		p = 0.09

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[1] Correspondence to: Nestor Schor. Department of Nephrology - UNIFESP/EPM (Paulista School of Medicine). Rua Botucatu, nº 740, São Paulo, SP, Brazil. CEP: 04023-900. Tel: +55 (11) 5573-9652. E-mail: nestor@nefro.epm.br

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Effect of vitamin D3 overdose and calcium supplementation in experimental nephrolithiasis model

Introduction:

Objective:

Methods:

Results:

Conclusion:

Effect of vitamin D₃ overdose and calcium supplementation in experimental nephrolithiasis model