Quantification of bone gain in central giant cell granuloma of the jaws submitted to intralesional corticotherapy

Cavalcante, Israel L.; Barros, Caio César S.; Rodrigues, Karol A. M.; Osterne, Rafael L. V.; Cavalcante, Roberta B.; Nogueira, Renato M.; Medeiros, Renata C. T.

doi:10.5935/1676-2444.20180032

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PATHOLOGY, ORIGINAL ARTICLE • J. Bras. Patol. Med. Lab. 54 (3) • May-Jun 2018 • https://doi.org/10.5935/1676-2444.20180032 copy

Quantification of bone gain in central giant cell granuloma of the jaws submitted to intralesional corticotherapy

Quantificação de ganho ósseo em lesões centrais de células gigantes dos maxilares submetidas à corticoterapia intralesional

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Introduction:

The central giant cell granuloma (CGCG) is a bone alteration of unknown etiology that can affect the jaws and presents varied clinical behavior.

Objective:

To analyze radiographs from patients with CGCG submitted to intralesional corticosteroids, in order to quantify bone gain after treatment.

Methods:

Sixteen patients with the microscopic diagnosis of CGCG were selected from the Batista Memorial Hospital, in Fortaleza, Ceará, Brazil. Thirty-two radiographs (16 initial and 16 final) were evaluated by the mean pixel values of the affected region before and after the complete corticosteroid intralesional application protocol (six applications in biweekly intervals of triamcinolone hexacetonide).

Results:

Of the patients submitted to the study, 14 (87.5%) presented a mean increase in the values of pixels, understood as bone gain, in the radiographs after treatment with intralesional injections, and two (12.5%) did not present it. The comparison of the mean pixel values between the initial and final test sides showed p = 0.0027, which was statistically significant, confirming the increase in density in the studied regions.

Conclusion:

The tools for analysis of pixel values were useful in the quantification of bone gain in patients submitted to intralesional corticosteroid therapy, and these tools should be further explored and used during treatment as auxiliary methods in the evaluation of its efficacy.

Key words:
therapeutics; radiography panoramic; diagnosis

Patient	Sex	Age	Site	Pain	Cortical expansion	Tooth displacement	Tooth resorption	Cortical perforation
Patient 1	Male	10	Mandible	No	Yes	Yes	No	No
Patient 2	Female	24	Maxilla	Yes	No	Yes	No	No
Patient 3	Female	21	Mandible	Yes	Yes	Yes	Yes	Yes
Patient 4	Male	20	Maxilla	No	Yes	No	No	No
Patient 5	Female	19	Mandible	No	Yes	No	No	No
Patient 6	Male	9	Maxilla	No	Yes	Yes	No	Yes
Patient 7	Female	15	Mandible	Yes	Yes	Yes	Yes	Yes
Patient 8	Male	12	Mandible	No	Yes	Yes	No	No
Patient 9	Female	24	Mandible	No	Yes	No	No	No
Patient 10	Female	20	Maxilla	Yes	Yes	Yes	No	Yes
Patient 11	Female	9	Maxilla	No	Yes	Yes	No	No
Patient 12	Male	7	Maxilla	No	Yes	Yes	No	No
Patient 13	Male	25	Mandible	No	No	No	No	Yes
Patient 14	Female	9	Mandible	No	Yes	Yes	No	No
Patient 15	Female	18	Mandible	No	Yes	Yes	Yes	Yes
Patient 16	Female	19	Mandible	Yes	Yes	Yes	Yes	Yes

Data	Mean initial pixel values	Mean final pixel values	Result
Patient 1	-55.347	-14.278	41.069
Patient 2	- 113.976	73.408	187.384
Patient 3	- 112.468	87.596	200.064
Patient 4	-126.287	-115.515	10.772
Patient 5	-95.212	9.594	104.806
Patient 6	57.52	118.965	61.445
Patient 7	- 128.351	30.04	158.391
Patient 8	-6.209	28.188	34.397
Patient 9	-52.619	-28.417	24.202
Patient 10	-21.012	-59.995	-38.983
Patient 11	- 39.004	30.845	69.849
Patient 12	60.175	77.035	16.86
Patient 13	- 44.941	7.214	52.155
Patient 14	-78.135	33.694	44.441
Patient 15	11.659	3.096	-8.563
Patient 16	-56.089	-40.118	15.971

Sociedade Brasileira de Patologia Clínica, Rua Dois de Dezembro,78/909 - Catete, CEP: 22220-040v - Rio de Janeiro - RJ, Tel.: +55 21 - 3077-1400 / 3077-1408, Fax.: +55 21 - 2205-3386 - Rio de Janeiro - RJ - Brazil
E-mail: jbpml@sbpc.org.br

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[1] CORRESPONDING AUTHOR. Israel Leal Cavalcante, Departamento de Odontologia; Universidade Federal do Rio Grande do Norte; Av. Senador Salgado Filho, 1787; Lagoa Nova; CEP: 59056-000; Natal-RN, Brasil; Phone/Fax: +55 (84) 3215-4138; e-mail: isrraelleal@hotmail.com.