ABSTRACT
A 34-year-old female patient attended a referral center for oral diagnosis presenting hardened increased volume in the posterior mandible. Panoramic radiography revealed a mixed unilocular lesion with clear and well-defined limits. The incisional biopsy showed proliferation of mesenchymal cells amid dense fibrous connective tissue. Mineralized material in different degrees of maturation was also observed. Regarding the histopathological aspects associated with the clinical, radiographic, and intraoperative data, the diagnosis of central ossifying fibroma (COF) was performed. COF has similar characteristics to other fibro-osseous lesions, and its diagnosis is a challenge for dental surgeons.
Key words:
ossifying fibroma; oral pathology; diagnosis
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A and B) images in lower magnification showing the presence of mineralized materials in different degrees of mineralization, sometimes forming trabeculae similar to bone tissue (100×) (A), sometimes forming basophilic spherules similar to cementoid material (B); C) stroma of richly cellularized dense fibrous connective tissue showing basophilic spherules (200×); D) trabecular bone showing apparent osteoblastic surface layer (400×).