A rare case of synchronous malignant thoracic tumors

Abstracts

Tumores neurogênicos malignos do mediastino em adultos são raros e extremamente agressivos. Este artigo relata o caso de um paciente de 61 anos com a ocorrência simultânea de schwannoma maligno de mediastino e carcinoma bronquíolo-alveolar. Apesar do carcinoma bronquíolo-alveolar estar presente em 4-7% dos tumores torácicos sincrônicos ressecados, essa associação nunca foi apresentada na literatura. É, no entanto, um achado frequente em pacientes com infiltrados aparentemente inflamatórios e com opacidades em vidro fosco, como apresentado neste caso.

Neoplasias do mediastino; Neoplasias da bainha neural; Neurilemoma; Neoplasias primárias múltiplas; Adenocarcinoma bronquíolo-alveolar

CASE REPORT

A rare case of synchronous malignant thoracic tumors^*

Benoit Jacques Bibas^I; Marcos Madeira^II; Rodrigo Gavina^III; Leonardo Hoehl-Carneiro^IV; Sergio Sardinha^V

^IResident in General Surgery. Hospital Central da Polícia Militar do Rio de Janeiro - HCPM, Central Hospital of the Rio de Janeiro Military Police - Rio de Janeiro, Brazil

^IICaptain Physician in the Thoracic Surgery Department. Hospital Central da Polícia Militar do Rio de Janeiro - HCPM, Central Hospital of the Rio de Janeiro Military Police - Rio de Janeiro, Brazil

^IIICaptain Physician in the Thoracic Surgery Department. Hospital Central da Polícia Militar do Rio de Janeiro - HCPM, Central Hospital of the Rio de Janeiro Military Police - Rio de Janeiro, Brazil

^IVLieutenant Physician in the Pathological Anatomy Department. Hospital Central da Polícia Militar do Rio de Janeiro - HCPM, Central Hospital of the Rio de Janeiro Military Police - Rio de Janeiro, Brazil

^VLieutenant Colonel Physician in the Thoracic Surgery Department. Hospital Central da Polícia Militar do Rio de Janeiro - HCPM, Central Hospital of the Rio de Janeiro Military Police - Rio de Janeiro, Brazil

Correspondence to

ABSTRACT

Malignant neurogenic mediastinal tumors in adults are uncommon and extremely aggressive. We report the case of a 61-year-old male patient with the simultaneous occurrence of malignant mediastinal schwannoma and bronchioloalveolar carcinoma. Although bronchioloalveolar carcinoma is present in 4-7% of the resected synchronous thoracic tumors, this association has never been reported in the literature. However, it is a common finding in patients presenting apparently inflammatory infiltrates and ground-glass opacities, as in the case presented here.

Keywords: Mediastinal neoplasms; Nerve sheath neoplasms; Neurilemmoma; Neoplasms, multiple primary; Adenocarcinoma, bronchiolo-alveolar.

Introduction

Neurogenic tumors are the most common mediastinal tumors, accounting for 20-35% of all of the mediastinal neoplasms.^(1,2) Neurogenic tumors are also responsible for approximately 75% of all lesions in the posterior mediastinum, although they are typically benign and asymptomatic. When symptoms are present, they should raise the suspicion of a malignant lesion.⁽³⁾

Neurogenic mediastinal tumors can originate in any neural structure within the chest and are classified according to their origin: those originating in the peripheral nerve sheaths, those originating in the sympathetic nervous system and those originating in the parasympathetic nervous system. Sympathetic tumors are classified as neuroblastomas, ganglioneuroblastomas or ganglioneuromas. Parasympathetic tumors are uncommon and include functioning paragangliomas (pheochromocytomas) and nonsecreting chemodectomas.⁽¹⁾

Of all of the neurogenic mediastinal tumors, 40-65% originate from the peripheral nerve sheath. Schwannomas (neurilemmomas) and neurofibromas, both benign lesions, account for over 95% of the tumors in this group. Malignant peripheral nerve sheath tumors (malignant schwannomas) are extremely aggressive and account for the remaining 2-4%.⁽²⁾

Case report

A 61-year-old male patient sought treatment in the emergency room of our institution reporting subscapular pain for two months. The patient reported that, in the beginning, the pain was tolerable when controlled with common analgesics. However, it became increasingly intense. There were no symptoms other than pain, and the patient reported no cough, hoarseness, fever, chills, night sweats, weight loss, hemoptysis, dyspnea or exposure to TB. He was a 30-pack-year smoker and a social drinker. The patient stated that he had no family history of neoplasms.

A physical examination revealed good general health and nutritional status, and vital signs were normal. The patient presented no lymph node enlargement. Upon pulmonary auscultation, there were fine inspiratory rales throughout both lung bases. The cardiac auscultation was normal. Examination of the abdomen and lower limbs revealed no alterations. The results of the blood workup and biochemical analyses were within the limits of normality. A CT scan of the chest (Figure 1a) revealed a well-defined mass, with regular borders, in the right costovertebral region, measuring 6 × 4.3 cm. Adjacent to the mass, we observed pulmonary infiltrates, apparently inflammatory and nonspecific (Figure 1b).

A right posterolateral thoracotomy was performed. We observed a large unencapsulated mass, lobulated and densely adhered to the costovertebral region, extending from T7 to T8 and infiltrating the vertebral bodies of these ribs, as well as the heads of the seventh and eighth ribs. In addition, there was a macroscopic invasion of the lower pulmonary lobe. The tumor was excised en bloc, together with a wedge resection of the affected lung parenchyma. Complete resection of the lesion was not possible and there was evident residual disease in the costochondral region as well as in the body of the seventh rib.

Histopathology showed spindle cell neoplasia, with extensive necrosis, moderate mitotic index and severe atypia, consistent with high-grade sarcoma, probably a malignant peripheral nerve sheath tumor (Figure 2a). The immunohistochemical assay was positive for S-100 protein, confirming the diagnosis of malignant schwannoma. We were surprised to find a bronchioloalveolar carcinoma was in the parenchyma Of the resected lung (Figure 2b). The lesion was 2.5 cm along its longest axis and affected the resection margins. The two neoplasms were separated by healthy lung tissue, confirming the distinct origin of the lesions.

The patient received adjuvant radiotherapy. However, over the following months, he developed medullary compression and flaccid paralysis, dying four months after the surgery.

Discussion

Malignant mediastinal schwannomas account for approximately 2% of all neurogenic mediastinal tumors in adults.^(1,2) They present as a mass on chest X-rays and are usually asymptomatic. When such tumors provoke symptoms, pain is the most common manifestation.⁽²⁾ Malignant mediastinal schwannomas are almost exclusively located in the posterior mediastinum and are usually large, measuring from 6 to 13 cm, with a mean diameter of 9 cm.⁽⁴⁾ In the macroscopic examination, their surface is unencapsulated, whitish or sometimes yellowish and with areas of hemorrhage, necrosis or both.⁽⁵⁾ Immunohistochemistry shows that these tumors are S-100 protein-reactive in 50-90% of cases.⁽⁵⁾ The mechanisms have yet to be established. However, there is growing evidence that S-100 family proteins have great influence on carcinogenesis as well as on the genesis of tumor metastases, interacting with a series of other proteins and genes, such as p53, COX-2 and BRCA1.⁽⁶⁾

Malignant neurogenic mediastinal tumors are extremely aggressive and associated with a low five-year survival rate. Local invasion, hematogenous metastases and pulmonary metastases frequently occur.⁽²⁾ Local recurrence and metastases are usual.⁽³⁾ Findings suggestive of malignancy on CT scans are as follows: low density areas; compression of adjacent structures; pleural abnormalities, such as pleural effusion or pleural nodules; and metastatic pulmonary nodules.⁽⁴⁾ Erosion of bone structures and pain are not uncommon findings and also suggest malignancy.⁽⁵⁾ Radical surgical resection with wide margins is the treatment of choice. When complete resection is not feasible, a simple excision without wide margins or a subtotal excision followed by radiotherapy in high doses are possible alternatives.⁽³⁾ Adjuvant radiotherapy and chemotherapy do not seem to increase survival but are useful in the treatment of the metastatic disease.⁽³⁾ Surgical cure is rarely possible.⁽¹⁾

The simultaneous occurrence of a malignant mediastinal schwannoma and bronchioloalveolar carcinoma is unprecedented. Resection of multiple thoracic neoplasms accounts for approximately 4% of all lung cancer resections, and most cases occur between the sixth and seventh decade of life.⁽⁷⁾ The genesis of synchronous tumors can be attributed to pathogenic factors intrinsic to the individual or can be related to a random phenomenon.⁽⁷⁾ According to two authors,⁽⁸⁾ synchronous thoracic tumors are defined as those that are diagnosed simultaneously with the index tumor, are separated from the index tumor by areas of healthy lung parenchyma and do not share lymphatic drainage with the index tumor. Histopathological characteristics, morphology, location, vascular invasion and immunohistochemical analysis should also be taken into consideration in the differentiation of the tumors.⁽⁹⁾ Different histology in clearly distinct neoplasms is pathognomonic of the primary nature of the lesions. However, this occurs in only 10-15% of the cases.^(7,10)

Areas of ground-glass opacity on tomography scans of the chest are unspecific findings and may represent various conditions, such as pulmonary edema, alveolar proteinosis, alveolitis, interstitial pneumonitis and neoplasms.⁽¹¹⁾ A diagnosis of neoplasia in ground-glass pulmonary infiltrates, as in this case, is common. One group of authors⁽¹¹⁾ evaluated 20 cases of patients with ground-glass infiltrates submitted to surgical resection. Of those, 50% were diagnosed with bronchioloalveolar carcinoma and 10% were diagnosed with adenocarcinomas. In addition, 25% were diagnosed with atypical adenomatous hyperplasia, which is considered the precursor lesion of bronchioloalveolar carcinoma.

Although it is the most common malignant neoplasia of the peripheral nervous system, malignant schwannoma is still one of the least studied sarcomas. The five-year survival rate is low and is negatively affected by the size of the lesion, incomplete resection and concomitance with Von Recklinghausen disease.⁽³⁾ Complete resection is usually impossible. Adjuvant radiotherapy and chemotherapy can be useful in the treatment of the metastatic disease. The lesion is rare as are its symptoms. Therefore, a high level of clinical suspicion is recommended in order to correctly diagnose this rare neoplasia. It is likely that the combination of malignant schwannoma and bronchioloalveolar carcinoma was a random phenomenon and did not influence the outcome of the case, which was a consequence of the aggressive nature of the mediastinal lesion. However, the presence of neoplasia should always be suspected in patients presenting pulmonary infiltrates and localized ground-glass opacities that do not disappear or grow. In such cases, an aggressive approach should be adopted, with early biopsy and histopathological analysis.

References

• 1. Teixeira JP, Bibas RA. Surgical treatment of tumors of the mediastinum: the Brazilian experience. In: Martini N, Vogt-Moykopf I, editors. Thoracic surgery: Frontiers and uncommon neoplasms. International trends in general thoracic surgery. St. Louis: Mosby; 1989. p.211-225.
• 2. Wain JC. Neurogenic tumors of the mediastinum. Chest Surg Clin North Am. 1992;2:121-36.
• 3. Macchiarini P, Ostertag H. Uncommon primary mediastinal tumours. Lancet Oncol. 2004;5(2):107-18.
• 4. Moon WK, Im JG, Han MC. Malignant schwannomas of the thorax: CT findings. J Comput Assist Tomogr. 1993;17(2):274-6.
• 5. Shields TW. Benign and malignant neurogenic tumors of the mediastinum in adults. In: Shields TW, LoCicero III J, Ponn RB, editors. General Thoracic Surgery. Philadelphia: Lippincott Williams &Wilkins; 2000. p. 2313-2327.
• 6. Salama I, Malone PS, Mihaimeed F, Jones JL. A review of the S100 proteins in cancer. Eur J Surg Oncol. 2008;34(4):357-64.
• 7. Rostad H, Strand TE, Naalsund A, Norstein J. Resected synchronous primary malignant lung tumors: a population-based study. Ann Thorac Surg. 2008;85(1):204-9.
• 8. Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975;70(4):606-12.
• 9. Chang YL, Wu CT, Lee YC. Surgical treatment of synchronous multiple primary lung cancers: experience of 92 patients. J Thorac Cardiovasc Surg. 2007;134(3):630-7. Erratum in: J Thorac Cardiovasc Surg. 2008;136(2):542.
• 10. Trousse D, Barlesi F, Loundou A, Tasei AM, Doddoli C, Giudicelli R, et al. Synchronous multiple primary lung cancer: an increasing clinical occurrence requiring multidisciplinary management. J Thorac Cardiovasc Surg. 2007;133(5):1193-200.
• 11. Nakajima R, Yokose T, Kakinuma R, Nagai K, Nishiwaki Y, Ochiai A. Localized pure ground-glass opacity on high-resolution CT: histologic characteristics. J Comput Assist Tomogr. 2002;26(3):323-9.

*

Trabalho realizado no Hospital Central da Polícia Militar do Rio de Janeiro - HCPM - Rio de Janeiro (RJ) Brasil.

Publication Dates

• Publication in this collection
  06 Mar 2009
• Date of issue
  Feb 2009

History

• Accepted
  13 May 2008
• Received
  29 Dec 2007