Comparison between reference values for FVC,
                  FEV<sub>1</sub>, and FEV<sub>1</sub>/FVC ratio in White adults in Brazil and those
               suggested by the Global Lung Function Initiative 2012

Pereira, Carlos Alberto de Castro; Duarte, Andrezza Araujo Oliveira; Gimenez, Andrea; Soares, Maria Raquel

doi:10.1590/S1806-37132014000400007

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Original Articles • J. bras. pneumol. 40 (4) • Jul-Aug 2014 • https://doi.org/10.1590/S1806-37132014000400007 copy

Comparison between reference values for FVC, FEV₁, and FEV₁/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012^* * Study carried out at the Pulmonary Function Laboratory, Centro Diagnóstico Brasil, São Paulo, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

OBJECTIVE:

To evaluate the spirometry values predicted by the 2012 Global Lung Function Initiative (GLI) equations, which are recommended for international use, in comparison with those obtained for a sample of White adults used for the establishment of reference equations for spirometry in Brazil.

METHODS:

The sample comprised 270 and 373 healthy males and females, respectively. The mean differences between the values found in this sample and the predicted values calculated from the GLI equations for FVC, FEV₁, and VEF₁/FVC, as well as their lower limits, were compared by paired t-test. The predicted values by each pair of equations were compared in various combinations of age and height.

RESULTS:

For the males in our study sample, the values obtained for all of the variables studied were significantly higher than those predicted by the GLI equations (p < 0.01 for all). These differences become more evident in subjects who were shorter in stature and older. For the females in our study sample, only the lower limit of the FEV₁/FVC ratio was significantly higher than that predicted by the GLI equation.

CONCLUSIONS:

The predicted values suggested by the GLI equations for White adults were significantly lower than those used as reference values for males in Brazil. For both genders, the lower limit of the FEV₁/FVC ratio is significantly lower than that predicted by the GLI equations.

Respiratory function tests/statistics and numerical data; Respiratory function tests/diagnosis; Reference values

Variable	Gender
	Male			Female
	Δ	t	p	Δ	t	p
FVC	0.29 ± 0.62	7.81	< 0.001	−0.01 ± 0.38	−0.75	0.46
LL	0.30 ± 0.59	9.41	< 0.001	0.01 ± 0.38	0.65	0.52
FEV₁	0.28 ± 0.50	9.06	< 0.001	0.00 ± 0.33	0.36	0.72
LL	0.29 ± 0.48	10.12	< 0.001	−0.02 ± 0.33	−0.93	0.36
FEV₁/FVC	0.93 ± 4.89	3.14	0.002	0.02 ± 5.00	0.06	0.95
LL	3.27 ± 4.71	11.43	< 0.001	3.68 ± 5.23	13.55	< 0.001

Variable	Age, years	Height, cm	Pereira et al.⁽¹⁶⁾	GLI^(19,21)
FVC, L	25	175	5.35	5.18
	50	170	4.58	4.48
	75	165	3.80	3.44
LL	25	175	4.45	4.19
	50	170	3.68	3.50
	75	165	2.90	2.52
FEV₁, L	25	175	4.50	4.35
	50	170	3.69	3.56
	75	165	2.90	2.61
LL	25	175	3.74	3.51
	50	170	2.93	2.78
	75	165	2.14	1.85
FEV₁/FVC	25	175	0.85	0.85
	50	170	0.81	0.80
	75	165	0.77	0.76
LL	25	175	0.77	0.73
	50	170	0.73	0.69
	75	165	0.69	0.62

Variable	Age, years	Height, cm	Pereira et al.⁽¹⁶⁾	GLI^(19,21)
FVC, L	25	162	3.82	3.84
	50	158	3.18	3.24
	75	153	2.47	2.31
LL	25	162	3.18	3.07
	50	158	2.54	2.53
	75	153	1.83	1.63
FEV₁, L	25	162	3.23	3.30
	50	158	2.60	2.60
	75	153	1.90	1.79
LL	25	162	2.62	2.65
	50	158	1.93	2.03
	75	153	1.32	1.28
FEV₁/FVC	25	162	0.85	0.87
	50	158	0.81	0.81
	75	153	0.78	0.78
LL	25	162	0.77	0.75
	50	158	0.73	0.70
	75	158	0.68	0.64

Sociedade Brasileira de Pneumologia e Tisiologia SCS Quadra 1, Bl. K salas 203/204, 70398-900 - Brasília - DF - Brasil, Fone/Fax: 0800 61 6218 ramal 211, (55 61)3245-1030/6218 ramal 211 - São Paulo - SP - Brazil
E-mail: jbp@sbpt.org.br

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[1] Correspondence to: Carlos A. C. Pereira. Avenida Iraí, 393, conj. 34, CEP 04082-001 São Paulo, SP, Brasil. Tel. 55 11 5543-8070. E-mail: pereirac@uol.com.br

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Comparison between reference values for FVC, FEV1, and FEV1/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012* * Study carried out at the Pulmonary Function Laboratory, Centro Diagnóstico Brasil, São Paulo, Brazil.

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSIONS:

Comparison between reference values for FVC, FEV₁, and FEV₁/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012^* * Study carried out at the Pulmonary Function Laboratory, Centro Diagnóstico Brasil, São Paulo, Brazil.