ABSTRACT
Background:
Colon cancer (CC) one of the most common oncological disease in World. Up to 30% patients in Russia have metastatic CC at first visiting to oncologist. The treatment results still controversial. Nowadays, minimally invasive laparoscopic precision technique allowed extending the indication for cytoreductive surgery even in patients with severe comorbidities.
Materials and methods:
89 patients with colon cancer (T1-4a) and curable synchronous distant metastases include in study. All patients underwent cytoreductive surgery with primary tumor resection. In study group (44) we performed laparoscopic surgery, in main group (45) - open surgery procedure. The groups were similar by sex, age, tumor localization and histological structure, comorbidities.
Results:
R0 resection performed 27% patients. The average number of lymph node removal was similar 13 and 12 respectively. Average operation time was significantly longer in study group 210 vs 120 min. In study group blood loss was lower: 300 mL vs 1200 mL. Postoperative patient recovery shorter after laparoscopic surgery (p < 0.05): time to activation 2.2 vs 3.9 days; time to first peristalsis - 1.8 vs 4.5 days; first bowel movement - 3.4 vs 4.8 days; first food taken - 2.9 vs 3.9 days. Shorter time of analgesics intake - 2.3 vs 4.4 days, p < 0.05. Hospital stay shorter: 9.3 vs 13.4 days, p = 0.05. Time to start chemotherapy reduced since 27.5 to 14.7 days, p < 0.05. Postoperative complications lower in study group: 6.8 vs 17.8%, p = 0.05. Kaplan-Meier 2-year overall survival were similar: 69.5% vs 61.6%, p = 0.96.
Conclusion:
Laparoscopic cytoreductive surgery for metastatic CC is safe, minimized surgical trauma and speed up patient recovery.
Keywords:
Laparoscopic surgery for colorectal cancer; Cytoreductive surgery; Metastatic colorectal cancer
