Abstract
Introduction
Chronic constipation is the most common digestive complaint at the doctor's office, with high prevalence in the population. However, many patients – and even those physicians not so familiar with pelvic floor disorders–define and consider constipation based on intestinal functionality and stool consistency. But symptoms of incomplete defecation, digital maneuvers, abdominal discomfort, and straining should not be overlooked.
Objectives
To investigate the correlation between constipation referred and documented through objective criteria in patients admitted on a daytime-nursing ward basis at the Hospital Santa Marcelina, São Paulo.
Methodology
This is a prospective study of a random sample of patients admitted on a daytime-ward hospitalization basis at Santa Marcelina Hospital to perform minor surgical procedures not related to functional disorders of the gastrointestinal tract in the period from September 2014 to June 2015; the only exclusion criterion was “not agreed to participate in the interview conducted by students of medicine at Santa Marcelina Medical School”.
Results
102 patients were randomly analyzed in the period considered (51% female) with a mean overall age of 48.6 (19–82) years. Constipation has been reported spontaneously by 17.6% of participants and denied by 82.4%. With the implementation of the Cleveland Clinic's criteria for the diagnosis of constipation, the compliance with the referred symptomatology was 88.9%; the same value was found with the use of the Rome III criteria (Kappa = 0.665). In addition, a higher incidence of constipation was observed in female patients (p = 0.002).
Conclusion
A higher incidence of constipation was observed in female participants, with no statistical difference with respect to age. Furthermore, a substantial agreement was found between constipation referred and constipation documented through objective criteria.
Keywords
Constipation; Rome criteria; Kappa index
Resumo
Introdução
A constipação intestinal crônica representa a queixa digestiva mais comum no consultório com elevada prevalência na população. No entanto, frequentemente, os pacientes e mesmo os médicos, não tão afeitos com os distúrbios do assoalho pélvico, definem e consideram constipação baseados na funcionalidade intestinal e consistência das fezes. Entretanto, os sintomas de defecação incompleta, manobras digitais, desconforto abdominal e esforço evacuatório não devem ser negligenciados.
Objetivos
Verificar a correlação entre constipação intestinal referida e constatada através de critérios objetivos em pacientes internados em regime de enfermaria dia no Hospital Santa Marcelina, São Paulo.
Metodologia
Estudo prospectivo de amostra aleatória de pacientes internados em enfermaria dia do Hospital Santa Marcelina para realização de cirurgias de pequeno porte e não relacionadas a distúrbios funcionais de trato gastrintestinal no período entre setembro de 2014 e junho de 2015, cujo único critério de exclusão foi o não consentimento em participar da entrevista realizada pelos alunos do curso de medicina da Faculdade Santa Marcelina.
Resultados
Foram analisados de forma aleatória 102 pacientes no período sendo 51% do sexo feminino e média de idade global de 48,6 anos (19-82 anos). A constipação foi referida de forma espontânea em 17,6% e negada em 82,4%. Ao se utilizar o critério da Cleveland Clinic para constatar constipação houve uma concordância com o sintoma referido fora de 88,9%, com mesmo valor ao se utilizar os critérios de Roma III (Kappa = 0,665). Além disso, verificou-se maior incidência de constipação intestinal nos pacientes do sexo feminino (p = 0,002).
Conclusão
Verificou-se maior incidência de constipação no sexo feminino sem diferença estatística baseado na idade. Além disso, constatou-se concordância substancial entre a constipação referida e a documentada através de critérios objetivos.
Palavras-chave
Constipação intestinal; Critérios de Roma; Índice de Kappa
Introduction
Chronic constipation is the most common digestive complaint in the general population, with high prevalence,11 Sonnenberg A, Koch T.R. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989; 34:606-11 affecting 16% of adults and up to 33% of those aged above 60 years,22 Bharucha A.E, Dorn S.D, Lembo A, Pressman A. American gastroenterological association medical position statement on constipation. Gastroenterology. 2013; 144:211-7 especially female subjects.33 Bharucha A.E, Pemberton J.H, Locke III G.R. American gastroenterological association technical review on constipation. Gastroenterology. 2013; 144:218-38 Consequently, this is a morbidity that implies a large number of visits for medical care, although in most cases there is no threat to the patient's life nor debilitation, but with a change in his/her quality of life, especially in chronic cases.22 Bharucha A.E, Dorn S.D, Lembo A, Pressman A. American gastroenterological association medical position statement on constipation. Gastroenterology. 2013; 144:211-7 44 Tack J, Muller-Lissner S, Stanghellini V, Boeckxstaens G, Kamm M.A, Simren M, et al. Diagnosis and treatment of chronic constipation: a European perspective. Neurogastroenterol Motil. 2011; 23:697-710
Constipation is classified into primary and secondary types. In a primary constipation, one can verify a normal intestinal transit, outlet obstruction, or a slow colonic transit. On the other hand, the secondary type of constipation is caused by a metabolic disease or may have a mechanical, pharmacological or psychiatric cause.55 Camilleri M. Peripheral mechanisms in irritable bowel syndrome. N Engl J Med. 2012; 367:1626-35 66 Lindberg G, Hamid S, Malfertheiner P, Thomsen O, Fernandez L.B, Garisch J, et al. Constipação: uma perspectiva mundial. World Gastroenterology Organisation Practice Guidelines. 2010; 1-15 Moreover, the main risk factors for constipation are already known: aging, female gender, depression, inactivity, low caloric intake, low income and low educational level, physical and sexual abuse, and previous surgeries.66 Lindberg G, Hamid S, Malfertheiner P, Thomsen O, Fernandez L.B, Garisch J, et al. Constipação: uma perspectiva mundial. World Gastroenterology Organisation Practice Guidelines. 2010; 1-15
Often the patient – and even that physician not so familiar with pelvic floor disorders – defines and considers constipation based on intestinal functionality and stool consistency.77 Oliveira J.C, Albuquerque F.R.P.C, Lins I.B. Projeção da população do Brasil por sexo e idade para o período de 1980-2050–Revisão 2004. Rio de Janeiro: IBGE; 2004. But symptoms of incomplete defecation, digital maneuvers, abdominal discomfort and straining should not be overlooked.88 Sandler R.S, Drossman D.A. Bowel habits in young adults not seeking health care. Dig Dis Sci. 1987; 32:841-5
Thus, in order to standardize the diagnosis and management of constipation, researchers described objective data in order tornozelo ascertain (or not) the morbidity by Rome I, II, III criteria99 Thompson D.G, Drossman D.A, Heaton K.W, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroent Int. 1989; 2:92-5 1010 Drossman D.A. The functional gastrointestinal disorders and the Rome II process. Gut. 1999; 45:II1-5 1111 Longstreth G.F, Thompson W.G, Chey W.D, Houghton L.A, Mearin F, Spiller R.C. Functional bowel disorders. Gastroenterology. 2006; 130:1480-91 and by the Cleveland Clinic constipation index.1212 Agachan F, Chen T, Pfeifer T, Reissman P, Wexner S.D. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 1996; 39:681-5
Purpose
This study aimed to verify the correlation between referred versus documented constipation according to objective criteria in patients admitted on a daytime-ward hospitalization basis at Santa Marcelina Hospital, São Paulo.
Patients and method
This is a prospective study in which a random sample of patients admitted on a daytime-nursing ward basis at Santa Marcelina Hospital to perform minor surgical procedures not related to functional disorders of the gastrointestinal tract were interviewed during the period from September 2014 to June 2015.
The only exclusion criterion was “not agreed to participate in the interview conducted by students of medicine at Faculdade Santa Marcelina”.
The surveyed data were: gender, age, comorbidities, and parity. After this general interview, patients were asked to tell whether or not they had constipation and, at that time, only an answer “yes” or “no” was accepted. After this spontaneous report of the complaint, a targeted anamnesis was carried out, through the utilization of the Rome III criteria,1010 Drossman D.A. The functional gastrointestinal disorders and the Rome II process. Gut. 1999; 45:II1-5 the Cleveland Clinic constipation index, Florida1111 Longstreth G.F, Thompson W.G, Chey W.D, Houghton L.A, Mearin F, Spiller R.C. Functional bowel disorders. Gastroenterology. 2006; 130:1480-91 and stool consistency.1313 Lewis S.J, Heaton K.W. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997; 32:920-4
Results
Regarding gender, 51% were female and the mean overall age was 48.6 (19–82) years, with a mean of 48.2 and 48.9 years for males and females, respectively. Twenty-nine percent and 6% of female and male participants, respectively, had constipation (p = 0.002). Moreover, when stratifying the age in groups of <20 years, 20–60 years and >60 years, no statistically significant difference was found between these subgroups with respect to the incidence of constipation (p = 0.576) (Fig. 1).
Of the 18 patients who reported constipation, 15 (83.3%) were female, 4 were nulliparous (26.7%) (p = 0.036) and the mean age was 51.6 years (Table 1). When stratifying the age of constipated patients, a mean of 48 and 66.3 years was found for female and male subjects, respectively. In this subgroup, only two (1.9%) patients had comorbid conditions with a risk factor for constipation (hypothyroidism).
Constipation has been referred spontaneously in 17.6%, and 82.4% denied this condition. When using the Cleveland Clinic criteria1212 Agachan F, Chen T, Pfeifer T, Reissman P, Wexner S.D. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 1996; 39:681-5 for the establishment of constipation, an agreement of 88.9% was achieved with that symptom, and the same value was obtained using the Rome III criteria1111 Longstreth G.F, Thompson W.G, Chey W.D, Houghton L.A, Mearin F, Spiller R.C. Functional bowel disorders. Gastroenterology. 2006; 130:1480-91 (Kappa = 0.665). An agreement of 90.5% was achieved between the referred denial for constipation versus absence of constipation with the application of the Rome III criteria. Regarding stool consistency,1313 Lewis S.J, Heaton K.W. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997; 32:920-4 67.5% of respondents reported type 3 or 4. On the other hand, among the constipated patients 69% reported type 1 or 2.
Discussion
The prevalence of constipation is variable in the literature, depending mainly on the age chosen to obtain these values. Thus, it is known that this variation covers 2–35% of the population, with a mean of 2.5 million clinical consultations a year.1414 Adibi P, Behzad E, Pirzadeh S, Mohseni M. Bowel habit reference values and abnormalities in young Iranian healthy adults. Dig Dis Sci. 2007; 52:1810-3 1515 Corazziari E. Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004; 18:613-31 1616 Peppas G, Alexiou V.G, Mourtzoukou E, Falagas M.E. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008; 8:5 Moreover, the prevalence is higher in females (this was also demonstrated in our study), institutionalized persons, and in the elderly.66 Lindberg G, Hamid S, Malfertheiner P, Thomsen O, Fernandez L.B, Garisch J, et al. Constipação: uma perspectiva mundial. World Gastroenterology Organisation Practice Guidelines. 2010; 1-15 1717 Kinnunen O. Study of constipation in a geriatric hospital, day hospital, old people's home and at home. Aging (Milano). 1991; 3:161-70
Obtaining a history of constipation of a patient is a debatable topic with regard to what are the auxiliary means to be used in the decision-making process. However, with the completion of a detailed history, one can determine if, in fact, the patient meets the objective criteria of constipation, as established by the Rome or the Cleveland Clinic criteria (cited above). Moreover, the physician can infer whether he/she is facing a case suggestive of outlet obstruction, by determining the occurrence of multiple bowel movements and small fecal volumes, a feeling of incomplete evacuation, and the need to a digital (perineal, anal or vaginal) maneuver, as well as the feeling of vaginal bulging during evacuation.1818 Mellgren A.F, Zetterstrom J, Lopez A. Recocele. Complex anorectal disorders: investigation and management. London: Springer-Verlag; 2005. 446-60 1919 Acosta A. Camilleri Elobixibat and its potential role in chronic idiopathic constipation. Ther Adv Gastroenterol. 2014; 7:167-75
The clinical history also enables an assessment of risk factors, such as poor diet, low fluid intake, immobility, psychiatric illness, medication use, comorbidities, previous surgery, and symptoms of irritable bowel syndrome.1515 Corazziari E. Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004; 18:613-31 2020 Hutchinson R, Kumar D. Colonic and small-bowel transit studies. Constipation: etiology evaluation and management. Oxford: Butterworth-Heinemann Ltd.; 1995. 52-62 2121 Collete V.L, Araújo C.L, Madruga S.W. Prevalência e fatores associados à constipação intestinal: um estudo de base populacional em Pelotas, Rio Grande do Sul, Brasil, 2007. Cad Saúde Pública. 2010; 26:1391-402 Finally, the clinical history allows the identification of warning signs such as hematochezia, a significant weight loss, a family history of cancer, anemia, anal bleeding, and a change in bowel habits – indicating the timeliness of a colonic study by colonoscopy and/or some radiological procedure without propedeutic intent with respect to constipation, but in order to exclude secondary causes for this condition.33 Bharucha A.E, Pemberton J.H, Locke III G.R. American gastroenterological association technical review on constipation. Gastroenterology. 2013; 144:218-38
Thus, when obtaining a clinical history, the questioning for constipation can be accomplished in a self-referred manner and also by objective criteria. It is known that the self-referred strategy may be influenced by social custos; in addition, the patient can consider as constipation the eventual use of laxatives and the occurrence of an abdominal colic, this way adopting the definition of the pathology in accordance with what he/she believes to be an adequate bowel habit.2222 Talley N.J. Definitions epidemiology, and impact of chronic constipation. Rev Gastroenterol Disord. 2004; 4:S3-S10
On the other hand, the Rome consensus1111 Longstreth G.F, Thompson W.G, Chey W.D, Houghton L.A, Mearin F, Spiller R.C. Functional bowel disorders. Gastroenterology. 2006; 130:1480-91 and the constipation index1212 Agachan F, Chen T, Pfeifer T, Reissman P, Wexner S.D. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 1996; 39:681-5 have been developed in order to standardize the definition of constipation in epidemiological studies, and also for the diagnosis of this condition in clinical practice.
Collette et al.,2121 Collete V.L, Araújo C.L, Madruga S.W. Prevalência e fatores associados à constipação intestinal: um estudo de base populacional em Pelotas, Rio Grande do Sul, Brasil, 2007. Cad Saúde Pública. 2010; 26:1391-402 in their demographic survey for the presence of constipation in the population of Pelotas, RS, found a prevalence of 26.9%, more often occurring in women; and an involvement of 37% among those individuals with a lower socioeconomic status. These authors also showed that the correlation between self-reported constipation and the establishment of constipation according to the Rome III consensus achieved an overall Kappa index of 0.59 (0.41 for men and 0.61 for women). In this same line, Garrigues et al.2323 Garrigues V, Galvez C, Ortiz V, Ponce M, Nos P, Ponce J. Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and selfreported definition in a population-based survey in Spain. Am J Epidemiol. 2004; 159:520-6 demonstrated a substantial agreement between self-reported constipation and the Rome I criteria (Kappa = 0.68) and a moderate agreement when using the Rome II criteria (Kappa = 0.55), concluding in favor of the usefulness of self-reported information of constipation by the interviewee, notwithstanding its subjective nature and reliance on multiple factors.
In our study, we found a significant correlation between constipation referred and that established through objective criteria, with a Kappa index of 0.665, and the female involvement with constipation was similar to that in the literature, as well as the evidence that the vast majority of constipated patients were women – a finding with statistical significance (p = 0.002). However, when stratifying the age in groups <20 years, 20–60 years, and >60 years, no statistically significant difference between these subgroups was found with respect to the incidence of constipation (p = 0.576).
Although the prevalence of constipation in male patients has been quite low, the male subjects in our sample were more aged versus females. This finding is similar to data from some published studies, showing that women are affected by this morbidity in an earlier age.2121 Collete V.L, Araújo C.L, Madruga S.W. Prevalência e fatores associados à constipação intestinal: um estudo de base populacional em Pelotas, Rio Grande do Sul, Brasil, 2007. Cad Saúde Pública. 2010; 26:1391-402 2424 Dukas L, Willett W.C, Giovannucci E.L. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol. 2003; 98:1790-6
Conclusion
In the present study, a predominance of constipation in women was noted, without difference in terms of mean age between constipated versus non-constipated patients. Furthermore, there was a substantial agreement between constipation referred and that documented by objective criteria.
Conflicts of interest
The authors declare no conflicts of interest.
-
☆
Study conducted by the Academic League of General Surgery, Santa Marcelina Medicine School; and by the Medical Residency Program of Coloproctology, Department of General Surgery, Santa Marcelina Hospital, São Paulo, SP, Brazil.
References
-
1Sonnenberg A, Koch T.R. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989; 34:606-11
-
2Bharucha A.E, Dorn S.D, Lembo A, Pressman A. American gastroenterological association medical position statement on constipation. Gastroenterology. 2013; 144:211-7
-
3Bharucha A.E, Pemberton J.H, Locke III G.R. American gastroenterological association technical review on constipation. Gastroenterology. 2013; 144:218-38
-
4Tack J, Muller-Lissner S, Stanghellini V, Boeckxstaens G, Kamm M.A, Simren M, et al. Diagnosis and treatment of chronic constipation: a European perspective. Neurogastroenterol Motil. 2011; 23:697-710
-
5Camilleri M. Peripheral mechanisms in irritable bowel syndrome. N Engl J Med. 2012; 367:1626-35
-
6Lindberg G, Hamid S, Malfertheiner P, Thomsen O, Fernandez L.B, Garisch J, et al. Constipação: uma perspectiva mundial. World Gastroenterology Organisation Practice Guidelines. 2010; 1-15
-
7Oliveira J.C, Albuquerque F.R.P.C, Lins I.B. Projeção da população do Brasil por sexo e idade para o período de 1980-2050–Revisão 2004. Rio de Janeiro: IBGE; 2004.
-
8Sandler R.S, Drossman D.A. Bowel habits in young adults not seeking health care. Dig Dis Sci. 1987; 32:841-5
-
9Thompson D.G, Drossman D.A, Heaton K.W, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroent Int. 1989; 2:92-5
-
10Drossman D.A. The functional gastrointestinal disorders and the Rome II process. Gut. 1999; 45:II1-5
-
11Longstreth G.F, Thompson W.G, Chey W.D, Houghton L.A, Mearin F, Spiller R.C. Functional bowel disorders. Gastroenterology. 2006; 130:1480-91
-
12Agachan F, Chen T, Pfeifer T, Reissman P, Wexner S.D. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 1996; 39:681-5
-
13Lewis S.J, Heaton K.W. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997; 32:920-4
-
14Adibi P, Behzad E, Pirzadeh S, Mohseni M. Bowel habit reference values and abnormalities in young Iranian healthy adults. Dig Dis Sci. 2007; 52:1810-3
-
15Corazziari E. Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004; 18:613-31
-
16Peppas G, Alexiou V.G, Mourtzoukou E, Falagas M.E. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008; 8:5
-
17Kinnunen O. Study of constipation in a geriatric hospital, day hospital, old people's home and at home. Aging (Milano). 1991; 3:161-70
-
18Mellgren A.F, Zetterstrom J, Lopez A. Recocele. Complex anorectal disorders: investigation and management. London: Springer-Verlag; 2005. 446-60
-
19Acosta A. Camilleri Elobixibat and its potential role in chronic idiopathic constipation. Ther Adv Gastroenterol. 2014; 7:167-75
-
20Hutchinson R, Kumar D. Colonic and small-bowel transit studies. Constipation: etiology evaluation and management. Oxford: Butterworth-Heinemann Ltd.; 1995. 52-62
-
21Collete V.L, Araújo C.L, Madruga S.W. Prevalência e fatores associados à constipação intestinal: um estudo de base populacional em Pelotas, Rio Grande do Sul, Brasil, 2007. Cad Saúde Pública. 2010; 26:1391-402
-
22Talley N.J. Definitions epidemiology, and impact of chronic constipation. Rev Gastroenterol Disord. 2004; 4:S3-S10
-
23Garrigues V, Galvez C, Ortiz V, Ponce M, Nos P, Ponce J. Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and selfreported definition in a population-based survey in Spain. Am J Epidemiol. 2004; 159:520-6
-
24Dukas L, Willett W.C, Giovannucci E.L. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol. 2003; 98:1790-6
Publication Dates
-
Publication in this collection
Jul-Sep 2016
History
-
Received
24 Feb 2016 -
Accepted
11 Apr 2016