INTRODUCTION: Slowing and epileptiform activity in EEG-patterns as well as epileptic seizures have been published during antipsychotic therapy with phenothiazines and butyrophenones. More recently, olanzepine, a new class of antipsychotic drug for use in treatment of refractory schizophrenics has been associated with a low risk of epileptic seizure occurrence. METHODS: We studied two patients, 45 and 37 years old, with schizophrenia and generalized epileptic seizures appearing, respectively, four and one month after starting olanzapine treatment. Their electroencephalogram showed spike-wave discharges generalized in one case and focal in the second patient. CONCLUSION: It was observed an association between epileptic seizures and olanzapine use.
EEG; antipsychotic treatment; seizures
