In this paper the authors discuss the ultrastructural changes of liver cells in the acute toxaemic form of schistosomiasis mansoni in five member of the same family who got the infection in identical conditions in an endemic area located near the Pampulha Lake, in Belo Horizonte (MG) and that did not receive specific treatment for schistosomiasis. This study confirms the data obtained and documented in a prior communication in seven patients infected in Sabará (MG). In the five cases the ultrastructural changes were also non-specific, although more intense than observed previuosly and were characterized mainly by alteration of the cytoplasmic organelles that could explain the common feature of clear cells by light microscopy. The results of the observation of some granulomas in ultrathin sections have demonstrated eosinophils, macrophages, plasma cells, epithelioid cells and mast cells. Among these cells there were also ground substance and thin bundles of collagen.