Pancreatic lipoprotein lipase has been studied in pancreas of normal rat and after submitting these animals to several experiments. The conclusions are the follwing: a) pancreas is very rich in this enzyme (8 times more than adipose tissue). b)Total activation of 48 hours decreases significantty lipoprotein lipase ativity of pancreas. c) Complamin a, derivative of nicotinic acid (having some activity against) experimental atherogenesis), does not affect activity ofthe pancreatic enzyme.