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• Mem. Inst. Oswaldo Cruz 87 (suppl 5) • 1992 • https://doi.org/10.1590/S0074-02761992000900021 linkcopy

Open-access Recent advances and prospective researches on molecular epidemiology of dengue viruses

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    Abstract

    The determination of amino acid changes in the envelop protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variations in the envelope protein-gene and virus virulence is discussed.

    dengue virus; molecular epidemiology; sequencing; envelope protein

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    Instituto Oswaldo Cruz, Ministério da Saúde Av. Brasil, 4365 - Pavilhão Mourisco, Manguinhos, 21040-900 Rio de Janeiro RJ Brazil, Tel.: (55 21) 2562-1222, Fax: (55 21) 2562 1220 - Rio de Janeiro - RJ - Brazil
    E-mail: memorias@fiocruz.br
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