Abstract
In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.
human cutaneous leishmaniasis; Brazil; chemotherapy; immunotherapy
Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
Loic Monjour1
Asit B. Neogy1
Ioannis Vouldoukis2
Otamires A. Silva1
Sylvie Boisnic3
Maria Edileuza F. Brito4
Annette Lesot3
Nicole Vignot3
Jane S. Martins5
Marcio L. Jardim5
Faculté de Médecine Pitié-Salpétrière, Laboratoire de Parasitologie, Paris, France
Faculté de Médecine Pitié-Salpétrière, Laboratoire de Parasitologie, Paris, Paris, France
Hôpital Pitié-Salpétrière, Département d' Anatomo-Pathologie, Paris, France
FIOCRUZ, Centro de Pesquisas Aggeu Magalhães, Recife, Brasil
UFPE, Departamento de Dermatologia, Recife, Brasil
In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.
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Publication Dates
-
Publication in this collection
15 June 2009 -
Date of issue
Sept 1994
