Acute melatonin administration enhances aerobic tolerance: an analysis of biochemical and hematological parameters

Beck, Wladimir Rafael; Messias, Leonardo Henrique Dalcheco; Silva, Franciele Carneiro da; Manchado-Gobatto, Fúlvia Barros; Gobatto, Claudio Alexandre

doi:10.1590/S1980-6574201800010014

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Original Article • Motriz: rev. educ. fis. 24 (02) • 2018 • https://doi.org/10.1590/S1980-6574201800010014 copy

Acute melatonin administration enhances aerobic tolerance: an analysis of biochemical and hematological parameters

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Aims

This study is aimed at testing the acute melatonin administration (oral; 6 mg) on aerobic tolerance at cycloergometer and analyzing the consequences on biochemical and hematological parameters.

Methods

The maximal aerobic capacity intensity (iMAC) at cycloergometer of eleven male healthy men (24.18±3.92 years-old; 87.07±12.48 kg; 1.82±0.05 m; 26.18±3.63 kg/m²; and 16.28±5.77 % of fat) was individually determined and used to perform a time to exhaustion (tlim) trial of 30 minutes after melatonin or placebo administration. We observed 48-72h interval between tests, performed in a double-blind experiment design. In order to determine hematological and biochemical parameters we collected venous blood samples before and after tlim. Statistical significance was set at 5%.

Results

The intensity and the lactatemia corresponding to the maximal aerobic capacity were 120.88±18.78 W and 3.32±1.03 mmol.L^-1, respectively. The tlim with placebo (33.94±15.26 min, confidence interval = 24.92 - 42.95) was significantly lower than the tlim with melatonin (41.94±17.22 min; CI = 31.76 - 52.12; p = 0.03; 19.06%; effect size = 0.49). All of the 21 analyzed blood physiological variables resulted in no significant variation after tlim when placebo was compared to melatonin, except for total sera cholesterol (lower after exercise with melatonin).

Conclusion

Acute melatonin administration enhanced aerobic tolerance at iMAC in 19% at cycloergometer; however, the biochemical and hematological variables assessed were not significantly modulated.

Keywords
maximal aerobic capacity; time to exhaustion; N-acetyl-5-methoxytryptamine; ergogenic aid.

	PR	PEx	MR	MEx	TREATMENT	EXERCISE	INTERACTION
WBC (10⁹/L)	7.46 ±1.97	11.03 ±2.79a	7.51 ±2.13	11.31 ±2.90b	F = 0.04 p = 0.83	F = 23.77 p < 0.01	F = 0.02 p = 0.88
NEUTR (10⁹/L)	4.19 ±1.55	5.71 ±2.34	4.24 ±1.63	5.77 ±2.15	F = 0.03 p = 0.85	F = 7.05 p = 0.01	F < 0.01 p = 0.93
LYMP (10⁹/L)	2.42 ±0.84	4.23 ±1.38a	2.50 ±0.68	4.40 ±1.11b	F = 0.07 p = 0.79	F = 7.06 p = 0.01	F < 0.01 p = 0.93
MONO (10⁹/L)	0.62 ±0.22	0.81 ±0.24a	0.60 ±0.19	0.86 ±0.28	F = 0.01 p = 0.92	F = 10.05 p < 0.01	F = 0.02 p = 0.88
RBC (10¹²/L)	5.08 ±0.29	5.45 ±0.34a	5.06 ±0.36	5.39 ±0.43	F = 0.33 p = 0.56	F = 10.37 p < 0.01	F = 0.16 p = 0.69
HB (g/dL)	14.64 ±1.02	15.68 ±1.07	14.44 ±0.97	15.43 ±1.04	F = 0.45 p = 0.50	F = 10.08 p < 0.01	F < 0.01 p = 0.96
HCT (%)	44.62 ±2.13	48.13 ±2.19a	44.60 ±2.11	47.64 ±2.54b	F = 0.26 p = 0.61	F = 22.58 p < 0.01	F = 0.23 p = 0.63
MCV (fL)	87.95 ±3.02	88.39 ±3.14	88.30 ±2.91	88.43 ±2.76	F = 0.25 p = 0.62	F = 0.11 p = 0.74	F = 0.01 p = 0.91
MCH (pg)	28.82 ±1.31	28.78 ±1.39	28.59 ±1.28	28.63 ±1.17	F < 0.01 p = 0.94	F < 0.01 p = 0.99	F = 0.26 p = 0.61
MCHC (g/dL)	32.74 ±1.19	32.55 ±1.17	32.37 ±0.97	32.38 ±0.88	F = 0.30 p = 0.58	F = 0.09 p = 0.76	F = 0.36 p = 0.55
RDW (%)	13.44 ±0.69	13.29 ±0.75	13.31 ±0.69	13.22 ±0.70	F = 0.25 p = 0.62	F = 0.34 p = 0.56	F = 0.01 p = 0.89
PLT 10⁹/L)	213.18 ±39.03	261.10 ±40.06a	199.00 ±41.09	256.37 ±35.33b	F = 0.37 p = 0.55	F = 19.51 p < 0.01	F = 0.34 p = 0.56

	PR	PEx	MR	MEx	TREATMENT	EXERCISE	INTERACTION
UA (mg/dL)	7.41 ±0.95	8.09 ±1.71	7.80 ±1.27	8.44 ±0.77	F = 0.94 p = 0.34	F = 3.04 p = 0.09	F < 0.01 p = 0.95
GLUC (mg/dL)	93.18 ±12.72	84.02 ±12.19	85.13 ±14.16	92.26 ±20.62	F < 0.01 p = 0.98	F = 0.05 p =0.83	F = 3.12 p = 0.85
TP (g/dL)	6.77 ±1.12	7.61 ±1.24	7.58 ±1.93	7.65 ±1.72	F = 0.74 p =0.39	F = 0.85 p = 0.36	F = 0.63 p =0.43
CHOL (mg/dL)	251.97 ±43.77	303.38 ±51.36	296.54 ±50.85	239.55 ±39.35bc	F = 0.38 p = 0.54	F = 0.03 p =0.86	F = 11.91 p < 0.01
TG (mg/dL)	125.24 ±26.20	123.08 ±27.69	140.54 ±35.66	138.32 ±21.73	F = 2.71 p =0.11	F = 0.05 p =0.81	F < 0.01 p = 0.99
CREAT (mg/dL)	1.03 ±0.51	1.38 ±0.53	1.77 ±1.13	1.77 ±0.90	F = 3.27 p = 0.08	F = 0.31 p = 0.58	F = 0.29 p = 0.59
UREA (mg/dL)	54.90 ±2.64	56.12 ±4.52	56.14 ±3.54	56.31 ±3.27	F = 0.44 p = 0.51	F = 0.42 p = 0.52	F = 0.24 p = 0.63
CK-NAK (U/L)	99.39 ±49.37	154.76 ±22.70	86.32 ±13.06	145.27 ±77.43	F = 0.14 p = 0.71	F = 3.60 p = 0.08	F < 0.01 p = 0.95
LDH (U/L)	131.32 ±28.67	136.88 ±25.08	135.71 ±35.27	155.44 ±28.63	F = 0.93 p = 0.34	F = 1.13 p = 0.29	F = 0.35 p = 0.56

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E-mail: motriz.rc@unesp.br

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[1] Corresponding author
Wladimir Rafael Beck. Department of Physiological Sciences, Federal University of Sao Carlos. Washington Luiz via, Km 235, CEP: 13565-905, Postal Code 676, Sao Carlos, Sao Paulo. beckwr@ufscar.br.