Analysis of the Total Level of Flavonoids in the Brown Algae ( <i>Phaeophyceae</i> ) Extract as Analgesic and Anti-Inflammatory Drugs

Tajrin, Andi; Chandha, Muh Hendra; Mappangara, Surijana; Ruslin, Muhammad; Samad, Rasmidar; Akbar, Fuad Husain

doi:10.1590/pboci.2020.103

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ORIGINAL ARTICLE • Pesqui. Bras. Odontopediatria Clín. Integr. 20 • 2020 • https://doi.org/10.1590/pboci.2020.103 copy

Analysis of the Total Level of Flavonoids in the Brown Algae ( Phaeophyceae ) Extract as Analgesic and Anti-Inflammatory Drugs

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective:

To determine the total level of flavonoids in brown algae extract Padina sp., Sargassum sp., and Turbinaria sp., which could serve as an analgesic and anti-inflammatory drug.

Material and Methods:

This is an experimental study with a one-shot case study research design. The study sample consisted of three species of brown algae, namely, Padina sp., Sargassum sp., and Turbinaria sp. The study samples were obtained from Saugi Island, Pangkep, Regency. The sampling method used was convenience sampling. The total flavonoid level in the three extracts of brown algae samples was determined at three concentrations (150 ppm, 300 ppm, and 450 ppm) with three replicates. The analysis used a colorimetric method, a spectrophotometer and aluminium chloride as the reagent.

Results:

The total level of flavonoids in Padina sp. was the highest at 0.894 ± 0.027%, compared to the levels of 0.786 ± 0.075% in Sargassum sp. and 0.745 ± 0.016% in Turbinaria sp.

Conclusion:

Padina sp. had the highest total flavonoid levels compared to Sargassum sp. and Turbinaria sp. Flavonoid compounds from brown algae have the potential to be used as analgesic and anti-inflammatory drugs.

Keywords:
Seaweed; Phaeophyta; Phytochemicals; Anti-Inflammatory Agents

Concentration	Replication	Absorbance	Level (%)	Mean (SD)
150 ppm	I	0.055	0.908	0.894 ± 0.027
	II	0.056	0.912
	III	0.045	0.864
300 ppm	I	0.084	0.518	0.567 ± 0.043
	II	0.119	0.595
	III	0.117	0.590
450 ppm	I	0.144	0.433	0.454 ± 0.018
	II	0.165	0.464
	III	0.166	0.465

Concentration	Replication	Absorbance	Level (%)	Mean (SD)
150 ppm	I	0.022	0.763	0.745 ± 0.016
	II	0.015	0.732
	III	0.017	0.741
300 ppm	I	0.017	0.370	0.385 ± 0.018
	II	0.021	0.379
	III	0.033	0.405
450 ppm	I	0.025	0.259	0.262 ± 0.003
	II	0.029	0.264
	III	0.029	0.264

Concentration	Replication	Absorbance	Level (%)	Mean (SD)
150 ppm	I	0.015	0.732	0.786 ± 0.075
	II	0.047	0.872
	III	0.020	0.754
300 ppm	I	0.039	0.419	0.407 ± 0.022
	II	0.040	0.421
	III	0.022	0.381
450 ppm	I	0.050	0.295	0.287 ± 0.055
	II	0.049	0.294
	III	0.035	0.273

Concentration	Total Flavonoid Level (%)
	Padina sp.	Turbinaria sp.	Sargassum sp.
150 ppm	0.894 ± 0.027	0.745 ± 0.016	0.786 ± 0.075
300 ppm	0.567 ± 0.043	0.385 ± 0.018	0.407 ± 0.022
450 ppm	0.454 ± 0.018	0.262 ± 0.003	0.287 ± 0.055

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[1] Author to whom correspondence should be addressed: Andi Tajrin, Department Oral Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia. Phone: +62 811 4556161. E-mail: tajrinazyes@gmail.com.