The objective of the present study was to evaluate the effect of stress management training in a group of hypertensive patients. Alterations of L-arginine-nitric oxide (NO) pathway were used as an evaluation criterion. Hypertensive (n=44) and normotensive (n=25) women participated in this study, and the stress management training was performed with a group of 14 hypertensive patients, observing the changes in the stress level and in L-arginine transport. In hypertension, the transport of L-arginine, via system y+, was reduced. Moreover, stressed hypertensive patients had a reduction of L-arginine transport by both systems, y+ and y+L, compared to stressed normotensive patients. The reduction of stress with stress management training in stressed hypertensive patients restored the transport of L-arginine via system y+ to the same levels of non-stressed hypertensive patients.
Stress; hypertension; cellular transport
