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Orbitofrontal Maturation, Somatic Markers and Early Vulnerability: A Comprehensive Hypothesis of "Emotional Myopia" in Drug Addiction

The “emotional myopia” hypothesis is a theoretical reflection to increase the understanding of the psychological vulnerability showed by many drug addicts Instead of an incorporation, a cooperation is proposed of levels of knowledge on the determinants of the neurodevelopment, psychoanalytical and attachment perspectives and psychobiological models of drug addictions. Environmental inputs that change brain morphology are highlighted, not only early trauma or care deprivation but also others derived from the long-term use of drugs as the core of vulnerability. We propose that Damasio’s hypothesis of somatic markers forms part of this theoretical formulation. The low quality of early social interactions may support an increasing emotional disengagement, a poor maturation of the social brain, an increase of alexithymic patterns and novelty-seeking behaviours, all potential triggers for searching for pleasure in drugs.

early interactions; emotional development; orbitofrontal córtex; alexithymia; drug addiction


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