Estudo transversal, com amostra consecutiva de 133 indivíduos. Foram considerados com DAOP pacientes com índice tornozelo braquial ≤ 0,90 ou com revascularização arterial. O nível sérico de vitamina D foi classificado em: suficiente (≥30 ng/mL), insuficiente (>20 a 29 ng/mL) e deficiente (<20 ng/mL). Razões de Prevalência (RP) foram calculadas por meio de regressão de Poisson.

RESULTADOS

A prevalência de DAOP foi de 50,7% (IC95% 42-59). Após ajuste para potenciais fatores de risco para DAOP, as RP foram de 1,08 (IC95% 0,66-1,76) para nível sérico insuficiente e de 1,57 (IC95% 0,96-2,57) para o nível sérico deficiente de vitamina D; (p para tendência = 0,020).

CONCLUSÃO

O nível sérico de vitamina D mostrou uma relação dose/resposta inversa e significativa com DAOP.

Doença arterial periférica; Aterosclerose; Vitamina D; Assistência ambulatorial; Estudo observacional

Variable	n (%)	% PAD	PR	95% CI	P value
Total:	144 (100)	50.7	-	(42.4-59.0)	-
Sex					< 0.001a
Female	77 (53.5)	23.4	1.00
Male	67 (46.5)	82.1	3.51	(2.30-5.35)
Age (years)					<0.001b
40-49	27 (18.7)	25.9	1.00
50-59	39 (27.1)	38.5	1.48	(0.70-3.15)
≥ 60	78 (54.2)	65.4	2.52	(1.14-5.55)
Color of skin					0.903a
White	94 (65.3)	51. 1	1.00
Non-white	50 (34.7)	50.0	0.98	(0.70-1.38)
Marital Status					0.745a
With partner	75 (52.3)	52.0	1.00
Without partner	69 (47.7)	49.3	0.95	(0.68-1.31)
Education (years)					<0.093b
≥ 9	26 (18.1)	46.2	1.00
5-8	58 (40.3)	41.4	0.90	(0.53-1.50)
0-4	60 (41.6)	61.7	1.34	(0.84-2.12)
Per capita income (tertiles)					<0.969b
I < BRL 1,400.00	34 (23.6)	52.9	1.00
II BRL 1,400.00 – 2,000.00	50 (34.7)	48.0	0.91	(0.59-1.39)
III >BRL 2,000.00	60 (41.7)	51.7	0.98	(0.65-1.46)
Smoking					< 0.001b
Never smoked	51 (35.4)	27.5	1.00
Ex-smoker	70 (48.6)	64.3	2.34	(1.45-3.79)
Smoker	23 (16.0)	60.9	2.22	(1.27-3.86)
Physical Activity (quantity)					0.129b
Practice ≥ 150 min/week	22 (15.2)	56.2	1.00
Practice < 150 min/week	26 (18.1)	38.5	0.94	(0.47-1.89)
Do not practice	96 (66.7)	40.9	1.37	(0.81-2.35)
Physical Activity (time)					0.064b
Practices for > 12 months	41 (27.0)	35.5	1.00
Practices for ≤ 12 months	7 (5.6)	47.1	1.32	(0.66-2.66)
Do not practice	96 (67.4)	56.2	1.58	(0.95-2.63)
Alcoholic beverages consumption					0.710b
Do not drink	75 (52.1)	52.0	1.00
<30g /day ♂ and <15g /day ♀ ≥30g /day ♂ and ≥15g /day ♀	56 (38.9)	44.6	0.86	(0.87-2.03)
<30g /day ♂ and <15g /day ♀ ≥30g /day ♂ and ≥15g /day ♀	13 (9.0)	69.2	1.33	(0.87-2.03)
General obesity					0.090a
No	83 (58.0)	56.3	1.00	(0.52-1.05)
Yes	60 (42.0)	41.7	0.73
Abdominal obesity					0.068a
No	53 (37.3)	60.4	1.00	(0.54-1.02)
Yes	89 (62.7)	44.9	0.74
Diabetes Mellitus					<0.001a
No	112 (77.8)	42.9	1.00	(1.37-2.42)
Yes	32 (22.2)	78.1	1.82
Dyslipidemias					<0.001a
No	71 (49.3)	25.3	1.00	(1.95-4.53)
Yes	73 (50.7)	75.3	2.97
Hypertension					0.008a
No	56 (38.9)	35.7	1.00	(1.14-2.49)
Yes	88 (61.1)	60.3	1.68
Vitamin D serum levels (ng/ml)					0.028b
Sufficient	25 (18.8)	36.0	1.00	(0.69-2.34)
Insufficient	48 (36.1)	45.8	1.27	(0.98-3.00)
Deficient	60 (45.1)	61.7	1.71	(0.98-3.00)

Variable	Model 1 P-value PR (95% CI)	Model 2 P-value PR (95% CI)	Model 3 P-value PR (95% CI)	Model 4 P-value PR (95% CI)	Model 5 P-value PR (95% CI)	Model 6 P-value PR (95% CI)	Model 7 P-value PR (95% CI)	Model 8 P-value PR (95% CI)
Vitamin D serum levels (ng/ml) Sufficient Insufficient Deficient	0.028a 1.00 1.27 (0.69-2.34) 1.71 (0.98-3.00)	0.035a 1.00 1.08 (0.65-1.81) 1.50 (0.92-2.46)	0.037a 1.00 1.11 (0.66-1.88) 1.51 (0.92-2.50)	0.038a 1.00 1.08 (0.65-1.81) 1.50 (0.92-2.44)	0.036a 1.00 1.07 (0.64-1.77) 1.53 (0.93-2.52)	0.042a 1.00 1.06 (0.63-1.78) 1.52 (0.91-2.55)	0.014a 1.00 1.08 (0.67-1.75) 1.60 (0.99-2.58)	0.020a 1.00 1.08 (0.66-1.76) 1.57 (0.96-2.57)

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[1] CORRESPONDING AUTHOR: Simone Bonatto Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, 1130 CEP 95070-560 - Caxias do Sul, RS, Brasil Fone 55 54 3218 2100 E-mail: sbonatto1@ucs.br