Clinical profile of patients with <i>myasthenia gravis</i>
               followed at the University Hospital, Federal University of Minas
               Gerais

Mourão, Aline Mansueto; Barbosa, Luiz Sérgio Mageste; Comini-Frota, Elizabeth Regina; Freitas, Denise da Silva; Gomez, Rodrigo Santiago; Burns, Ted M.; Lemos, Stela Maris Aguiar; Teixeira, Antonio Lúcio

doi:10.1590/1806-9282.61.02.156

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ORIGINAL ARTICLES • Rev. Assoc. Med. Bras. 61 (2) • mar-apr 2015 • https://doi.org/10.1590/1806-9282.61.02.156 copy

Clinical profile of patients with myasthenia gravis followed at the University Hospital, Federal University of Minas Gerais

Perfil clínico de pacientes com miastenia gravis em acompanhamento no Hospital das Clínicas, da Universidade Federal de Minas Gerais

Authorship SCIMAGO INSTITUTIONS RANKINGS

Summary

Objective:

to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series.

Methods:

sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies on the clinical profile of MG patients.

Results:

sixty nine patients were enrolled in the study. Fifty five (91%) subjects were female and the mean age (SD) was 37.6 (±11.4) years. The mean disease duration was 14.1 years. Regarding treatment, prednisone was the most used strategy (64%), followed by the use of azathioprine (43%). There was no difference between thymectomized (42) and non-thymectomized (27) patients regarding disease severity and medication use.

Conclusion:

clinical and socio-demographic features of this MG sample from a University-based clinic resemble those reported in other Brazilian series and in the international literature.

Keywords:
myasthenia gravis ; epidemiology; neurology; thymectomy; therapeutics

Data	Non-	Thymectomized	p
	-thymectomized		value
Gender			0.22
Female	30	25
Male	12	2
Age			0.36
18-50	31	23
> 50	11	4
Years of disease	14	14.2	0.55
First symptoms			0.86
Ocular	22	25
Bulbar	5	6
Generalized	5	6
Main symptoms			0.36
Ocular	15	8
Bulbar	10	11
Generalized	13	12
MFGA			0.19
I	9	4
IIA	10	4
IIB	2	0
IIIA	5	7
IIIB	3	7
IV	6	8
MG Composite	7.2 (4.7)	8 (5.1)	0.75
(mean ± SD)
Number of crises	3 (1.2)	9 (1.6)	0.07
(mean ± SD)
Treatment			0.75
Anticholinesterase	38	20
drug
Prednisone	22	22
Azathioprine	14	16
Plasmapheresis	0	1
Other	6	3
immunosuppressant

Study		N	F:M	Age (Mean)	Length of disease (years)	Main symptoms			Treatment
R						O	B	G	T	I	AZA	PDN	MS
25	Oliveira et al. 1995	52	6.4:1	27	3.1	0	0	52 (100%)	52 (100%)	0	0	52 (100%)	0
17	Saraiva et al. 1996	324	2.1:1	34.6	.	62 (19.1%)	16 (4.9%)	246 (75.9%)	16 (4.9%)	.	.	.	.
18	Cunha et al. 1999	153	2.1:1	32.1	6.2	103 (67.3%)	121 (79%)	76 (49.6%)	4 (2.6%)	.	.	.	.
19	Asis et al. 1999	41	1:1.4	45	5	1 (2.4%)	6 (14.6%)	10 (24.4%)	41 (100%)	.	9 (21.5%)	21 (51.2%)	10 (24.4%)
26	Almeida et al. 2000	90	3:1	28.2	3.4	.	.	.	0	0	11 (12.2%)	0	79 (87.8%)
24	Morrita et al. 2001	18	1.2:1	7.3	.	.	.	.	5 (27.8%)	.	1 (5.6%)	16 (88.9%)	.
20	Werneck et al. 2002	24	2.3:1	39.5	4.1	0	23 (95.8%)	1 (4.1%)	12 (50%)	3 (12.5%)	4 (16.7%)	17 (70.8%)	0
27	Oda et al. 2002	22	6.3:1	37.8	7.3	.	.	.	.	.	.	.	.
28	Saito et al. 2003	21	6:1	29.7	6	.	.	.	0	.	.	.	.
21	Maffeis et al. 2004	26	2.7:1	28	.	.	.	.	18 (69.2%)	.	.	.	.
22	Ruiz et al. 2004	46	2:1	30	26.3	4 (8.7%)	22 (47.8%)	20 (43.4%)	46 (100%)	0	1 (2.1%)	7 (15.2%)	9 (19.5%)
23	Mega et al. 2005	15	2.7:1	35	.	.	.	.	15 (100%)	.	.	.	.
29	Aguiar et al. 2010	122	2.2:1	31.9	8.9	6 (4.9%)	0	111 (94.1%)	52 (42.6%)	0	40 (32.8%)	109 (89.3%)	122 (100%)
30	Lorenzoni et al. 2013	53	4.9:1	42.1	15.1	28 (52.8%)	21 (39.6%)	4 (7.5%)	21 (39.6%)	0	46 (86.7%)	50 (94.3%)	52 (98.1%)
	Current study	69	4:1	37.6	14.1	23 (33.3%)	21 (30.4%)	25 (36.2%)	27 (39.1%)	9 (13%)	30 (43%)	44 (64%)	58 (84%)

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[1] * Correspondence: Address: Rua Itajuba, 1945/103, Sagrada Família Belo Horizonte, MG – Brazil Postal code: 31.035-540 Phone: (31) 3459-3200 (31) 9732-0286 alinemmourao@gmail.com