| Brudevold et al.1717 Brudevold R, Hole T, Hammerstrøm J. Hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload. PLoS ONE. 2008; 3(10):e3547.
|
2008 |
40 |
Patients with hyperferritinemia |
HPF was related to increased levels of C-peptide (p<0.002) and age (p<0.002),as well as IR |
| Yoneda et al.1212 Yoneda M, Nozaki Y, Endo H, Mawatari H, Iida H, Fujita K, et al. Serum ferritin is a clinical biomarker in Japanese patients with nonalcoholic steatohepatitis (NASH) independent of HFE gene mutation. Dig Dis Sci. 2010; 55(3):808-14.
|
2010 |
106 |
Patients with NAFLD |
HPF is associated with NASH (p=0.006) and correlated with HOMA-IR (r =0.212,p=0.048). Ideal ferritin cutoff point at 196 ng/mL (95CI 0.596-0.856, p=0.005) |
| Manousou et al.1111 Manousou P, Kalambokis G, Grillo F, Watkins J, Xirouchakis E, Pleguezuelo M, et al. Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients. Liver Int. 2011; 31(5):730-9.
|
2011 |
111 |
Patients with NAFLD |
HPF is associated with NASH (p=0.0001), portal (p=0.043) and lobular (p=0.009) inflammation, and AST (p=0.002) |
| Williamson et al.1818 Williamson RM, Price JF, Glancy S, Perry, E, Nee LD, Hayes PC, et al.; Edinburgh Type 2 Diabetes Study Investigators. Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care. 2011; 34(5):1139-44.
|
2011 |
939 |
Patients with MetS |
Associated features of MetS can be used as screening for NAFLD/NASH |
| Zimmermann et al.1616 Zimmermann A, Zimmermann T, Schattenberg J, Pöttgen S, Lotz J, Rossmann H, et al. Alterations in lipid, carbohydrate and iron metabolism in patients with non-alcoholic steatohepatitis (NASH) and metabolic syndrome. Eur J Intern Med. 2011; 22(3):305-10.
|
2011 |
37 |
Patients with MetS |
Higher insulinemia, C-peptide and IR in patients with NASH x non-NASH (p=0.034; 0.032 and 0.04) |
| Adams and Barton1515 Adams P, Barton J. A diagnostic approach to hyperferritinemia with a non-elevated transferrin saturation. J Hepatol. 2011; 55(2):453-8.
|
2011 |
- |
Patients with hyperferritinemia |
Serum ferritin has widely fluctuating values when associated with NASH/NAFLD |
| Kowdley et al.88 Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, et al.; NASH Clinical Research Network. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2012; 55(1):77-85.
|
2012 |
628 |
Patients with NAFLD |
Ferritin > 1.5 times the ULN was independently associated with advanced hepatic fibrosis (OR 1.66, 95CI 1.05-2.62; p=0.028) and increased NAS score (OR 1.99, 95CI 1.06-3.75, p=0.033) |
| Nakajima et al.1919 Nakajima T, Nakashima T, Yamaoka J, Shibuya A, Itoh Y, Yoshikawa T. Age is a negative, and visceral fat accumulation is a contributor to hepatic steatosis, regardless of the progression in non-alcoholic fatty liver disease. J Gastroenterol Hepatol Res. 2012; 1(11):315-9.
|
2012 |
60 |
Patients with NAFLD |
Steatosis/NAFLD correlates positively with area of visceral (r=0.321, p=0.0001) and subcutaneous (r=0.349, p<0.01) fat, and negatively with age (r=0.509,p<0.0001) |
| Chandok et al.33 Chandok N, Minuk G, Wengiel M, Uhanova J. Serum ferritin levels do not predict the stage of underlying non-alcoholic fatty liver disease. J Gastrointestin Liver Dis. 2012; 21(1):53-8.
|
2012 |
482 |
Patients with NAFLD |
Mean serum ferritin was similar in subjects with steatosis, NASH or cirrhosis (223.9 x 240.7 x 271.3, p=0.84) |
| Angulo et al.11 Angulo P, George J, Day CP, Vanni E, Russell L, De la Cruz AC, et al. Serum ferritin levels lack diagnostic accuracy for liver fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014; 12(7):1163-9.
|
2014 |
1,014 |
Patients undergoing liver biopsy |
HPF correlates positively with the severity of fibrosis (p<0.001), with less accuracy in patients with NAFLD |
| Cippà et al.77 Cippà PE, Boucsein I, Adams H, Krayenbuehl PA. Estimating iron overload in patients with suspected liver disease and elevated serum ferritin. Am J Med. 2014; 127(10):1011.e1-3.
|
2014 |
147 |
Patients with hyperferritinemia |
Only ferritin > 2,000 mg/L predicts iron overload, and ferritin/AST ratio is a predictor of tissue iron overload with sensitivity of 83.3% and specificity of 78.6% |
