Arízaga-Ballesteros et al., 201599. Arízaga-Ballesteros V, Alcorta-García MR, Lázaro-Martínez LC, Amézquita-Gómez JA, Alanís-Cajero JM, Villela L, et al. Can sTREM-1 predict septic shock & death in late-onset neonatal sepsis? A pilot study. Int J Infect Dis. 2015;30:27-32. https://doi.org/10.1016/j.ijid.2014.10.013 https://doi.org/10.1016/j.ijid.2014.10.0...
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In neonates with late-onset sepsis, sTREM-1 showed excellent predictive value (p<0.0001) for septic shock/death, with a specificity and sensitivity of 0.97 and 0.78, respectively. |
Saldir et al., 20151010. Saldir M, Tunc T, Cekmez F, Cetinkaya M, Kalayci T, Fidanci K, et al. Endocan and soluble triggering receptor expressed on Myeloid Cells-1 as novel markers for neonatal sepsis. Pediatr Neonatol. 2015;56(6):415-21. https://doi.org/10.1016/j.pedneo.2015.03.006 https://doi.org/10.1016/j.pedneo.2015.03...
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sTREM-1 levels were significantly higher (p<0.001) in neonates with sepsis than in neonates who did not have sepsis. |
Cordeiro et al., 20161111. Cordeiro CN, Savva Y, Vaidya D, Argani CH, Hong X, Wang X, et al. Mathematical modeling of the biomarker milieu to characterize preterm birth and predict adverse neonatal outcomes. Am J Reprod Immunol. 2016;75(5):594-601. https://doi.org/10.1111/aji.12502 https://doi.org/10.1111/aji.12502...
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TREM-1 had a strong influence on building a model that showed significant predictive value (p<0.05) for sepsis. |
Pontrelli et al., 201666. Pontrelli G, De Crescenzo F, Buzzetti R, Calò Carducci F, Jenkner A, Amodio D, et al. Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: A systematic review. Ital J Pediatr. 2016;42 (44):1-10. https://doi.org/10.1186/s13052-016-0242-y https://doi.org/10.1186/s13052-016-0242-...
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sTREM-1 can be used as a diagnostic tool for pediatric sepsis, but the results cannot be considered conclusive due to heterogeneity of the samples. |
Al-Asy et al., 20171212. Al-Asy HM, Gamal RM, Albaset AMA, Elsanosy MG, Mabrouk MM. New diagnostic biomarker in acute diarrhea due to bacterial infection in children. Int J Pediatr Adolesc Med. 2017;4(2):75-80. https://doi.org/10.1016/j.ijpam.2016.12.004 https://doi.org/10.1016/j.ijpam.2016.12....
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Children with acute bacterial infection showed significantly increased (p<0.05) sTREM-1 levels as compared to patients who had diarrhea without bacterial infection, showing a specificity and sensitivity of 93.7 and 94.3%, respectively. |
Özdemir et al., 20181313. Ozdemir SA, Ozer EA, Ilhan O, Sutcuoglu S, Tatlı M. Diagnostic value of urine soluble triggering receptor expressed on myeloid cells (sTREM-1) for late-onset neonatal sepsis in infected preterm neonates. J Int Med Res. 2018;46(4):1606-16. https://doi.org/10.1177/0300060517749131 https://doi.org/10.1177/0300060517749131...
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Neonates with confirmed sepsis had significantly higher urine sTREM-1 values (p<0.05) than those in the suspected sepsis group. The measurement of this marker in the urine showed a sensitivity and specificity of 0.90 and 0.78, respectively. |
Bellos et al., 20181414. Bellos I, Fitrou G, Daskalakis G, Thomakos N, Papantoniou N, Pergialiotis V. Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis. Inflamm Res. 2018;67(7):571-8. https://doi.org/10.1007/s00011-018-1149-4 https://doi.org/10.1007/s00011-018-1149-...
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sTREM-1 can be a useful biomarker for the prediction of neonatal sepsis, but the small number of studies and the variation in the limit values negatively impact its use in clinical practice. |
Özdemir et al., 20191515. Özdemir ZC, Düzenli-Kar Y, Canik A, Küskü-Kiraz Z, Özen H, Bör O. The predictive value of procalcitonin, C-reactive protein, presepsin, and soluble-triggering receptor expressed on myeloid cell levels in bloodstream infections in pediatric patients with febrile neutropenia. Turk J Pediatr. 2019;61(3):359-67. https://doi.org/10.24953/turkjped.2019.03.007 https://doi.org/10.24953/turkjped.2019.0...
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There was no significant difference (p>0.05) in blood sTREM-1 levels on days 1, 2, and 7 between patients with positive and negative blood culture results, suggesting that this marker is not appropriate for predicting blood infections. |
Zhang et al., 20201616. Zhang HF, Zhang X, Sha YX, Zhou HQ, Pan JH, Xun X, et al. Value of sTREM-1 in serum and bronchoalveolar lavage fluid, APACHE II score, and SOFA score in evaluating the conditions and prognosis of children with severe pneumonia. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(6):626-31. https://doi.org/10.7499/j.issn.1008-8830.1912134 https://doi.org/10.7499/j.issn.1008-8830...
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The severe pneumonia group had significantly higher serum sTREM-1 levels than the non-severe pneumonia and the control groups (p<0.05). |
Şen et al., 20201717. Şen S, Kamit F, Işgüder R, Yazici P, Şahbudak Bal1 Z, Devrim I, Bayram SN. Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis. Indian J Pediatr. 2021;88(2):134-40. https://doi.org/10.1007/s12098-020-03355-3 https://doi.org/10.1007/s12098-020-03355...
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TREM-1 values were significantly higher (p=0.048) in patients with septic shock than in those with severe sepsis. |