Diabetes control could through platelet-to-lymphocyte ratio in hemograms

Association between type 2 diabetes mellitus and inflammation is well-established. We aimed to study platelet-to-lymphocyte ratio (PLR), a novel inflammatory index derived from hemogram, in diabetic patients in comparison to those in healthy volunteers.

METHODS

Medical data of type 2 diabetics that showed up in general outpatient medical clinics of our institution between February 2017 and August 2017 were recorded and analyzed.

RESULTS

Median PLR of type 2 diabetic patients was significantly higher than the PLR of healthy controls (p=0.001). Moreover, PLR was significantly and positively correlated with HbA1c (p<0.001, r=0.58), fasting plasma glucose (p<0.001, r=0.49), and c-reactive protein (p=0.003, r=0.30) levels. Type 2 diabetic subjects with proteinuria had significantly higher PLR levels than that of diabetic subjects without proteinuria.

CONCLUSION

As an inexpensive and easy to use index, PLR may be useful in predicting the development and control levels of type 2 diabetes mellitus. However, its correlation with HbA1c needs to be validated by larger prospective studies.

Diabetes mellitus, type 2; Inflammation; Glycated hemoglobin A; Lymphocyte count; Platelet count

		Study Group	Control Group	p
Gender	Men (n)	30	9	0.11
	Women (n)	33	21	0.11
		Mean ± standard deviation
Age (years)		56 ± 9	45 ± 12	<0.001
Height (m)		1.62 ± 0.9	1.66 ± 0.8	0.08
Weight (kg)		82 ± 13	70 ± 8	<0.001
Body mass index (kg/m²)		31.4 ± 5.4	25.6 ± 4.2	<0.001
Waist circumference (cm)		106 ± 12	89 ±10	<0.001
		Median (min-max)
Systolic blood pressure (mmHg)		120 (90-180)	110 (100-130)	0.001
Diastolic blood pressure (mmHg)		80 (50-110)	70 (50-80)	0.04

	Study group	Control group	p
	Median (min-max)
Fasting plasma glucose (mg/dl)	162 (86-565)	95 (79-107)	<0.001
Serum creatinine (mg/dl)	0.82 (0.63-1.5)	0.75 (0.56-1.05)	0.06
Uric acid (mg/dl)	5.6 (3.2-8.6)	4.5 (2.1-10.4)	<0.001
CRP (U/l)	5 (0.1-45)	2.2 (0.1-11.9)	<0.001
Total cholesterol (mg/dl)	204 (94-325)	168 (114-248)	0.02
LDL- cholesterol (mg/dl)	123 (42-244)	111 (53-162)	0.12
HDL-cholesterol (mg/dl)	45 (25-86)	55 (39-77)	<0.001
Triglyceride (mg/dl)	166 (72-1050)	106 (52-297)	<0.001
WBC (u/mm³)	7.5 (4.4-13.7)	6.3 (3.4-9.7)	0.001
PLT (u/mm³)	245 (141-482)	208 (148-263)	<0.001
PLR	122 (44-472)	94 (48-170)	0.001
	Mean ± Standard Deviation
Hb (g/dl)	13.6 ± 1.6	13.6 ±1.9	0.92
Htc (%)	40 ± 4.6	40.3 ± 2.2	0.72

Associação Médica Brasileira R. São Carlos do Pinhal, 324, 01333-903 São Paulo SP - Brazil, Tel: +55 11 3178-6800, Fax: +55 11 3178-6816 - São Paulo - SP - Brazil
E-mail: ramb@amb.org.br

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[1] CORRESPONDING AUTHOR: Gulali Aktas. Abant Izzet Baysal University Hospital, Department of Internal Medicine, 14280, Bolu, Turkey – Telephone: +903742534656. E-mail: draliaktas@yahoo.com