OBJECTIVE: The present study was aimed at evaluating the reliability of the qualitative visual assessment of brain abnormalities using conventional brain MRI in extremely preterm infants. MATERIALS AND METHODS: A cohort of 45 consecutive infants with gestational age of 30 weeks or less (median of 27 weeks, ranging from 25 to 30 weeks) was enrolled in this study. Two independent, experienced neuroradiologists blindly reviewed MRI studies of the infants' brain for diffuse and excessive high-signal intensity (DEHSI), dilated lateral ventricles, intracranial hemorrhage, areas of abnormal signal in the basal ganglia and cortex, cyst-like areas, ventricular deformities, enlargement of subarachnoid spaces, early leukoencephalomalacia, and cortical abnormalities. RESULTS: Forty-one patients (91.1%) presented abnormalities at MRI. The most common findings were DEHSI in the white matter (75.6%) and ventricular dilatation (42.2%). The interobserver agreement was high (κ > 0.60) for most of the abnormal MRI findings. The kappa statistic values were moderate for enlargement of the subarachnoid space (κ = 0.52) and was only low for DEHSI in the white matter (κ = 0.39). CONCLUSION: Conventional MRI seems to be a reliable method for evaluating the most common brain abnormalities in extremely premature infants; however, the presence of DEHSI in the white matter demonstrated to be is a less reliable finding
Preterm; Brain; Magnetic resonance imaging; Imaging; Hypoxia
