Optimization of a protocol for myocardial perfusion scintigraphy by using an anthropomorphic phantom

Ramos, Susie Medeiros Oliveira; Glavam, Adriana Pereira; Kubo, Tadeu Takao Almodovar; Sá, Lidia Vasconcellos de

doi:10.1590/0100-3984.2013.1933

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ORIGINAL ARTICLES • Radiol Bras 47 (4) • Jul-Aug 2014 • https://doi.org/10.1590/0100-3984.2013.1933 copy

Optimization of a protocol for myocardial perfusion scintigraphy by using an anthropomorphic phantom^* * Study developed at Instituto de Radioproteção e Dosimetria / Comissão Nacional de Energia Nuclear (IRD/CNEN), Rio de Janeiro, RJ, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

To develop a study aiming at optimizing myocardial perfusion imaging.

Materials and Methods:

Imaging of an anthropomorphic thorax phantom with a GE SPECT Ventri gamma camera, with varied activities and acquisition times, in order to evaluate the influence of these parameters on the quality of the reconstructed medical images. The ^99mTc-sestamibi radiotracer was utilized, and then the images were clinically evaluated on the basis of data such as summed stress score, and on the technical image quality and perfusion. The software ImageJ was utilized in the data quantification.

Results:

The results demonstrated that for the standard acquisition time utilized in the procedure (15 seconds per angle), the injected activity could be reduced by 33.34%. Additionally, even if the standard scan time is reduced by 53.34% (7 seconds per angle), the standard injected activity could still be reduced by 16.67%, without impairing the image quality and the diagnostic reliability.

Conclusion:

The described method and respective results provide a basis for the development of a clinical trial of patients in an optimized protocol.

Myocardial perfusion imaging; Optimization; Anthropomorphic phantom

Phantom	Total activity (MBq)	Activity injected in the organ (MBq)
Heart	1,110	17.76 ± 0.89
	925	12.17 ± 0.61
	740	8.69 ± 0.43
	555	6.52 ± 0.33
Liver	1,110	124.54 ± 6.23
	925	80.66 ± 4.03
	740	52.98 ± 2.65
	555	39.74 ± 1.99
Body	1,110	153.55 ± 7.68
	925	76.22 ± 3.81
	740	56.61 ± 2.83
	555	42.46 ± 2.12

Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem Av. Paulista, 37 - 7º andar - conjunto 71, 01311-902 - São Paulo - SP, Tel.: +55 11 3372-4541, Fax: 3285-1690, Fax: +55 11 3285-1690 - São Paulo - SP - Brazil
E-mail: radiologiabrasileira@cbr.org.br

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[1] Mailing Address: Susie Medeiros Oliveira Ramos. Instituto de Radioproteção e Dosimetria, Departamento de Física Médica. Avenida Salvador Allende, s/nº, Jacarepaguá. Rio de Janeiro, RJ, Brazil, 22780-160. E-mail: susie@ird.gov.br.

555 MBq (without lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p	Prone 10 s/p	Prone 15 s/p	Prone 20 s/p
	Technical quality	C	B	B	B	B	B	C	C
	Perfusion	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal
	SSS	2	3	2	2	1	1	2	1
740 MBq (without lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p	Prone 10 s/p	Prone 15 s/p	Prone 20 s/p
	Technical quality	B	A	A	A	B	A	A	A
	Perfusion	Abnormal	Abnormal	Abnormal	Normal	Normal	Normal	Normal	Normal
	SSS	1	2	1	0	0	0	0	0
925 MBq (without lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p	Prone 10 s/p	Prone 15 s/p	Prone 20 s/p
	Technical quality	A	A	A	A	A	A	A	A
	Perfusion	Abnormal	Abnormal	Normal	Normal	Normal	Normal	Normal	Normal
	SSS	1	2	0	0	0	0	0	0

740 MBq (with lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p
	Technical quality	B	B	A	A	B
	Perfusion	Abnormal	Normal	Abnormal	Abnormal	Abnormal
	SSS	4	0	2	2	2
925 MBq (with lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p
	Technical quality	B	A	A	A	B
	Perfusion	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal
	SSS	2	2	2	2	2
1,110 MBq (with lesion)	Simulation	Supine 7 s/p	Supine 10 s/p	Supine 15 s/p	Supine 20 s/p	Prone 7 s/p
	Technical quality	A	A	A	A	A
	Perfusion	Abnormal	Abnormal	Abnormal	Abnormal	Abnormal
	SSS	3	2	2	2	2

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Optimization of a protocol for myocardial perfusion scintigraphy by using an anthropomorphic phantom* * Study developed at Instituto de Radioproteção e Dosimetria / Comissão Nacional de Energia Nuclear (IRD/CNEN), Rio de Janeiro, RJ, Brazil.

Objective:

Materials and Methods:

Results:

Conclusion:

Optimization of a protocol for myocardial perfusion scintigraphy by using an anthropomorphic phantom^* * Study developed at Instituto de Radioproteção e Dosimetria / Comissão Nacional de Energia Nuclear (IRD/CNEN), Rio de Janeiro, RJ, Brazil.