Interaction of solanaceous glycoalkaloids with anesthetic drugs

LETTERS TO THE EDITOR

Interaction of solanaceous glycoalkaloids with anesthetic drugs

Eugesse Cremonesi, TSA, M.D.

^{Correspondence}

Mr. Editor,

In a summary published in Anesthesiology, Moss, Krasowksi and McGehee presented an interesting study on the interaction of natural compounds found in potatoes, namely alpha solanine and alpha chaconine solanaceous glycoalkaloids (SGAs), with acetylcholinesterase (AchE) and butirylcholinesterase (BuChE).

The authors have studied the inhibitory effects of such compounds on AChE and BuChE, and concluded that SGAs inhibit BuChE in a more intensive way than AChE, in nanomolecular concentrations present in potato-consumers serum. They have also studied the possible anticholinesterase activity of other compounds, such as neuromuscular blockers, and have found that only pancuronium and vecuronium have a similar effect.

These results suggest that the above-mentioned glycoalkaloids may change neuromuscular blockers, local anesthetics and other drugs with BuChE-mediated hydrolysis pharmacokinetics. They also suggest that major changes in patients’ sensitivity to anesthetic drugs could be partially attributed to dietary factors.

Solanaceous glycoalkaloids are primarily found in potatoes, tomatoes and eggplants, and may interfere with neuromuscular blockers, local anesthetics, cardiovascular drugs and other BuChE hydrolyzed compounds metabolism, when regularly consumed or in large amounts the day before surgery.

REFERENCES

01. Moss J, Krasowski BA, McGehee DS - Anesthesiology, 1998;89: 3A:A1008.

02. Larkin M - Lancet, 1998;352:1362.

Correspondence to

Eugesse Cremonesi, TSA, M.D.

Address: Rua Dr. José de Moura Rezende, 165 Jardim Caxingui

ZIP: 05517-000 City: São Paulo, Brazil

Publication Dates

• Publication in this collection
  18 Oct 2005
• Date of issue
  June 2002