Sinclair et al. |
1997 |
Patients over 55 years undergoing hip replacement surgery |
CardioQ-guided GDHT by optimizing SV and cFT with fluids n 20 |
Standard care n 20 |
Length of stay, hemodynamic parameters |
RCT |
Conway et al. |
2002 |
ASA I–III patients undergoing colorectal surgery |
CardioQ-guided GDHT by optimizing SV with fluids n 29 |
Standard care n 28 |
Hemodynamic parameters, bowel function parameters, complications |
RCT |
Gan et al. |
2002 |
ASA I–III patients undergoing major surgery |
CardioQ-guided GDHT by optimizing SV with fluids n 50 |
Standard care n 50 |
Length of stay, complications |
RCT |
Venn et al. |
2002 |
Patients undergoing hip replacement surgery |
CardioQ-guided GDHT by optimizing SV with fluids n 30 |
Standard care n 29 |
Length of stay, hemodynamic parameters |
RCT |
Walkeling et al. |
2005 |
ASA I–III patients undergoing colorectal surgery in an ERAS protocol |
CardioQ-guided GDHT by optimizing SV with fluids n 64 |
Standard care (CVP 12–15 mmHg) n 64 |
Length of stay, oral tolerance, complications, quality of recovery |
RCT |
Nobblet et al. |
2006 |
Patients undergoing colorectal surgery |
CardioQ-guided GDHT by optimizing SV with fluids n 54 |
Standard care n 54 |
Length of stay, complications, bowel function recovery |
RCT |
Donati et al. |
2007 |
High-risk patients undergoing major abdominal surgery |
GDHT by optimizing ERO2 with fluids and inotropes n 68 |
Standard care n 67 |
Hemodynamic parameters, complications, length of stay |
RCT |
Lopes et al. |
2007 |
High-risk patients undergoing major abdominal surgery |
CNAP-guided GDHT by optimizing ΔPP < 10% n 17 |
Standard care n 16 |
Hemodynamic parameters, complications, ICU stay, length of stay |
RCT |
Buettner et al. |
2008 |
ASA I–III patients undergoing major abdominal surgery (general, gynecological) |
PPV-guided GTHD with fluids and vasopressors n 40 |
Standard care n 40 |
Tissue oxygenation parameters, hemodynamic parameters, length of stay |
RCT |
Senagore et al. |
2009 |
Low- and moderate-risk patients undergoing laparoscopic bowel resection in an ERAS protocol |
CardioQ-guided GDHT by optimizing SV with fluids n 21(LR) or HES 6% n 21 |
Standard care n 22 |
Complications, length of stay |
RCT |
Jammer et al. |
2010 |
Patients undergoing colorectal surgery |
ScvO2-guided GDHT with fluids n 121 |
Standard care n 120 |
Complications |
RCT |
Van der Linden et al. |
2010 |
ASA II–III patients undergoing low limb arterial by-pass |
Flotrac-guided GDHT maintaining a CI > 2.5 mL/min/m2 and CVP < 15 mmHg with fluids and inotropes. Sevoflurane anesthesia n 20 |
Standard care guided by APm and CVP n 17 |
Hemodynamic parameters, Complications, length of stay |
RCT |
Forget et al. |
2010 |
Patients undergoing major abdominal surgery |
Masimo-guided GDHT by optimizing PVI with fluids and vasopressors n 41 |
Standard care n 41 |
Amount of fluid administered, lactate levels, complications, length of stay, mortality |
RCT |
Mayer et al. |
2010 |
High-risk patients undergoing major abdominal surgery |
Flotrac-guided GDHT maintaining a CI > 2.5 mL/min/m2 with fluids, inotropes and vasopressors n 30 |
Standard care (restrictive) n 30 |
Length of stay, complications |
RCT |
Benes et al. |
2010 |
High-risk patients (ASA III–IV) undergoing major abdominal surgery |
Flotrac-guided GDHT by optimizing SVV with fluids and inotropes n 60 |
Standard care n 60 |
Complications, length of stay, ICU stay, mortality |
RCT |
Cecconi et al. |
2011 |
Patients undergoing hip replacement. Regional Anesthesia |
Flotrac-guided GDHT by optimizing SV and DOI > 600 mL/min/m2 with fluids, inotropes and vasopressors n 20 |
Standard care n 20 |
Amount of fluids administered, vasoactive use, complications, length of stay |
RCT |
Challand et al. |
2012 |
Patients undergoing colorectal surgery in an ERAS protocol. All patients |
CardioQ-guided GDHT by optimizing SV with fluids n 89 |
Standard care n 90 |
Length of stay, readmission, complications |
RCT |
Brandstrup et al. |
2012 |
ASA I–III patients undergoing colorectal surgery |
CardioQ-guided GDHT by optimizing SV with fluids n 71 |
Standard care. Zero balance n 79 |
Complications, length of stay |
RCT |
Bartha et al. |
2013 |
Patients over 70 years undergoing hip replacement in an ERAS protocol |
LiDCO plus guided GDHT by optimizing SV and DOI > 600 mL/min/m2 with fluids and inotropes n 74 |
Standard care n 75 |
Complications, amount of fluids administered, hemodynamic response, length of stay |
RCT |
Zhang et al. |
2013 |
ASA I–II patients undergoing gastrointestinal surgery |
PPV-guided GDHT with fluids: LR n 20; and HES 6% n 20 |
Standard care n 20 |
Length of stay, bowel function parameters, complications, hemodynamic parameters |
RCT |
Salzwedel et al. |
2013 |
ASA II–III patients undergoing major abdominal surgery |
ProAQT-guided GDHT maintaining a CI > 2.5 mL/min/m2 with fluids, inotropes and vasopressors n 79 |
Standard care n 81 |
Complications, length of stay |
RCT |
Scheeren et al. |
2013 |
ASA III–IV undergoing major abdominal surgery |
Flotrac-guided GDHT by optimizing SV and SVV with fluids n 26 |
Standard care n 26 |
Complications, SOFA score, ICU stay, mortality |
RCT |
Zhang et al. |
2013 |
ASA I–II undergoing lobectomy surgery |
Flotrac-guided GDHT by optimizing SVV and maintaining a CI > 2.5 mL/min/m2 with fluids and inotropes n 30 |
Standard care n 30 |
Length of stay, complications |
RCT |
Forget et al. |
2013 |
Low- and moderate-risk patients undergoing colorectal surgery in an ERAS protocol |
Masimo-guided GDHT by optimizing PVI with fluids (IPV < 13) n 10 |
Standard care n 11 |
Amount of fluids administered, complications, mortality, length of stay |
RCT |
Zakhaleva et al. |
2013 |
Patients undergoing colorectal surgery in an ERAS protocol |
CardioQ-guided GDHT by optimizing SV and cFT with fluids n 32 |
Standard care n 40 |
Time of surgery, amount of fluids administered, bowel function recovery, complications, length of stay, mortality |
RCT |
Srinivasa et al. |
2013 |
ASA I–III patients undergoing colorectal surgery without an ERAS protocol |
CardioQ-guided GDT by optimizing SV and cFT with fluids n 37 |
Standard care n 37 |
Hemodynamic parameters, complications |
RCT |
McKenny et al. |
2013 |
Patients undergoing major gynecological surgery |
CardioQ-guided GDHT by optimizing SV and cFT with fluids n 51 |
Standard care n 50 |
Complications, length of stay |
RCT |
Zheng et al. |
2013 |
Elderly high-risk patients undergoing major abdominal surgery |
Flotrac-guided GDHT by maintaining a CI > 2.5 mL/min/m2 with fluids and vasopressors n 30 |
Standard care n 30 |
Cardiovascular complications, bowel function parameters, ICU stay, length of stay |
RCT |
Peng et al. |
2014 |
Adult patients undergoing major orthopedic surgery |
Flotrac-guided GDHT to maintain SVV < 10 or <14% in prone position n 40 |
Standard care n 40 |
Splanchnic organ functions, postoperative complications |
RCT |