BACKGROUND: The study of polyps, especially adenomatous, is justified because of the straight correlation among them with the incidence of CRC. Objective: To analyze the risk factors for high-grade dysplasia of adenomatous polyps removed endoscopically. METHODS: All consecutive colonoscopies performed by the Colorectal Department of the Hospital Nossa Senhora da Conceição, in Porto Alegre/RS, from January 2003 to December 2006, were evaluated. Patients diagnosed with adenomatous polyps were included. The relationship among tumors with high-grade dysplasia and the features of the patients and polyps were analyzed. RESULTS: Among the 1,821 exams, 326 adenomas were detected in 208 patients. 51.4% of the patients were male; 69,2% had only one adenoma. A total of 28 patients (13,5%) with 34 adenomas (10,4%) with high-grade dysplasia were found. Among the tumors with high-grade dysplasia, 64.7% were = 1cm, 61.8% were sessile, 29.4% were villous, and 70.6% were located in the left colon. Comparing the characteristics of the group of tumors of low grade dysplasia with those of high-grade, the size = 1cm and villous component (P <0,001) were statistically significant. CONCLUSION: Adenomas = 1cm and dominance of villous component were considered independent risk factors for high-grade dysplasia.
Adenoma; Adenocarcinoma; Polyps; Colorectal neoplasms; Colonoscopy
