It is known that the preconditioning has the capacity to minimize the current lesions of the ischemia and reperfusion process. Recently it was described that the postconditioning presents similar results in miocardic ischemia and reperfusion, brain, kidneys and of the spinal cord, but there are no reports of use of this method in the mesenteric ischemia. OBJECTIVE: The objective of this study is to evaluate the effect of the postconditioning on the tissue lesion in the intestinal mucosa of rats submitted to the ischemia and reperfusion process. METHOD: 20 Wistar rats were studied, distributed in two groups: group A, in that was done mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B, mesenteric ischemia and reperfusion and, preceding the beginning of the reperfusion, the postconditioning was accomplished. At the end, it was dried up a segment of the small intestine for histological analysis. The results were evaluated by the Chiu's classification and the statistical treatment was proceeded. RESULTS: The averages of the degrees of tissue lesion were: group A, 3,5; group B, 1. The difference between the groups was statistically significant (p <0,05). CONCLUSION: The postconditioning was capable to minimize the tissue lesion in the intestinal mucosa of rats submitted to the mesenteric ischemia and reperfusion process.
Ischemia; Reperfusion; Postconditioning; Preconditioning; Rats; Animal experimentation
