AUC=area under the curve; CPB=cardiopulmonary bypass; ROC=receiver operating characteristics
Abbreviations, acronyms & symbols | ||||
---|---|---|---|---|
AAA | = Abdominal aortic aneurysm | ICU | = Intensive care unit | |
AAAD | = Acute type A aortic dissection | IQR | = Interquartile range | |
AD | = Aortic dissection | IRAD | = International Registry of Acute Aortic Dissection | |
ARD | = Acute renal dysfunction | LVEF | = Left ventricular ejection fraction | |
AUC | = Area under the curve | MC | = Mainland of China | |
BMI | = Body mass index | ROC | = Receiver operating characteristics | |
CA | = Circulatory arrest | RTAD | = Retrograde type A aortic dissection | |
CABG | = Coronary artery bypass grafting | SD | = Standard deviation | |
CAD | = Coronary artery disease | SPSS | = Statistical Package for the Social Sciences | |
COPD | = Chronic obstructive pulmonary disease | TAR | = Total aortic arch replacement | |
CPB | = Cardiopulmonary bypass | TEVAR | = Thoracic endovascular aortic repair | |
DSWI | = Deep sternal wound infection | TIA | = Transient ischemic attack | |
DTA | = Descending thoracic aorta | TND | = Transient neurologic dysfunction | |
ESM | = Extensive surgical management | WBCs | = White blood cells | |
FET | = Frozen elephant trunk ok | WHO | = World Health Organization | |
GERAADA | = German Registry of Acute Aortic Dissection Type A |
Variable | Value (%) |
---|---|
Age (years) | |
Mean ± SD | 48.36±9.57 |
Median (IQR) | 48 (42-53) |
Gender | |
Male (%) | 346 (76.2) |
Weight (kg) | |
Mean ± SD | 72.05±12.44 |
Median (IQR) | 71 (64-80) |
Smoking (%) | 200 (44.1) |
Alcohol drinking (%) | 172 (37.9) |
Previous cardiac surgery (%) | 12 (2.6) |
Duration of complaint | |
0-24 hours (%) | 254 (55.9) |
> 24 hours (%) | 188 (41.4) |
Diabetes mellitus | 44 (9.7) |
Hypertension (%) | 356 (78.4) |
Hyperlipidemia (%) | 30 (6.6) |
COPD (%) | 14 (3.1) |
CAD (%) | 16 (3.5) |
Aortic regurgitation ≥ grade 3 | 84 (18.5) |
Shock (%) | 14 (3.1) |
Malperfusion (%) | |
Stroke (%) | 6 (1.3) |
TIA (%) | 2 (0.4) |
Myocardial ischemia (%) | 116 (25.6) |
Renal dysfunction (%) | 36 (7.9) |
Mesenteric ischemia (%) | 0 |
Lower extremity (%) | 2 (0.4) |
Marfan syndrome (%) | 18 (3.9) |
LVEF% | |
Mean ± SD | 60.5±6.1 |
Median (IQR) | 60 (58-63.2) |
Elevated WBCs count (%) | 246 (54.2) |
Anemia (%) | 84 (18.5) |
Low platelets count (%) | 174 (38.1) |
Variable | Univariate P-value | Multivariate (P-value) |
---|---|---|
Age (years) | 0.855 | |
Mean ± SD | ||
Median (IQR) | ||
Gender | 0.174 | |
Male (%) | ||
Weight (kg) | 0.063 | 0.025 |
Mean ± SD | ||
Median (IQR) | ||
Smoking (%) | 0.869 | |
Alcohol drinking (%) | 0.014 | 0.002 |
Previous cardiac surgery (%) | 0.999 | |
Duration of complaint | ||
0-24 hours (%) | 0.047 | |
> 24 hours (%) | 0.428 | |
Diabetes mellitus | 0.733 | |
Hypertension (%) | 0.845 | |
Hyperlipidemia (%) | 0.345 | |
COPD (%) | 0.282 | |
CAD (%) | 0.124 | 0.014 |
Aortic regurgitation ≥ grade 3 | 0.509 | |
Shock (%) | 0.010 | 0.006 |
Malperfusion (%) | ||
Stroke (%) | 0.999 | |
TIA (%) | >0.999 | |
Myocardial ischemia (%) | 0.130 | |
Renal dysfunction (%) | 0.054 | |
Mesenteric ischemia (%) | ||
Lower extremity (%) | >0.999 | |
Marfan syndrome (%) | ||
LVEF% | ||
Mean ± SD | ||
Median (IQR) | ||
Elevated WBCs count (%) | 0.043 | 0.002 |
Anemia (%) | 0.206 | |
Low platelets count (%) | 0.768 |
Variable | Value (%) |
---|---|
Emergency (%) | 212 (46.7) |
Hybrid (%) | 88 (19.5) |
Bentall (%) | 150 (33) |
CABG (%) | 54 (11.9) |
Arterial cannulation method | |
Right axillary artery | 400 (88.1) |
Right axillary & right femoral arteries | 36 (7.9) |
Distal ascending aorta | 6 (1.3) |
Left femoral artery | 6 (1.3) |
Operation time (min) | |
Mean ± SD | 513.55±101.27 |
Median (IQR) | 501 (440-565) |
Clamp time (min) | |
Mean ± SD | 120.88±31.57 |
Median (IQR) | 122 (96-139) |
CPB time (min) | |
Mean ± SD | 225.18±55.01 |
Median (IQR) | 217 (189.5-251.25) |
CA time (min) | |
Mean ± SD | 26.77±8.73 |
Median (IQR) | 26 (21-30.75) |
Nasopharyngeal temperature (˚C) | |
Mean ± SD | 21.46±4.16 |
Median (IQR) | |
Cerebral perfusion | |
Unilateral antegrade | 328 (72.2) |
Bilateral antegrade | 92 (20.3) |
Variable | Univariate P-value | Multivariate (P-value) |
---|---|---|
Emergency (%) | 0.614 | |
Hybrid (%) | 0.521 | |
Bentall (%) | 0.909 | |
CABG (%) | 0.299 | |
Arterial cannulation method | 0.844 | |
Right axillary artery | ||
Right axillary & right femoral arteries | ||
Distal ascending aorta | ||
Left femoral artery | ||
Operation time (min) | < 0.0001 | < 0.008 |
Mean ± SD | ||
Median (IQR) | ||
Clamp time (min) | 0.014 | |
Mean ± SD | ||
Median (IQR) | ||
CPB time (min) | 0.0001 | |
Mean ± SD | ||
Median (IQR) | ||
CA time (min) | 0.422 | |
Mean ± SD | ||
Median (IQR) | ||
Nasopharyngeal temperature (˚C) | 0.278 | |
Mean ± SD | ||
Median (IQR) | ||
Cerebral perfusion | 0.239 | |
Unilateral antegrade | ||
Bilateral antegrade |
Variable | Value (%) |
---|---|
30-day mortality (%) | 70 (15.4) |
Mortality in hybrid repair (%) | 13 (14.7) |
Mortality in FET+TAR (%) | 57 (15.6) |
Stroke (%) | 30 (6.6) |
TND (%) | 168 (37) |
Hemiplegia (%) | 2 (0.4) |
DSWI (%) | 20 (4.4) |
ARD (%) | 68 (15) |
Pulmonary infection (%) | 144 (31.7) |
Tracheotomy (%) | 74 (16.3) |
Ventilation time (h) | |
Mean ± SD | 124.25±122.94 |
Median (IQR) | 89 (40-165) |
ICU readmission (%) | 50 (11) |
Variable | Univariate P-value | Multivariate (P-value) |
---|---|---|
30-day mortality (%) | ||
Stroke (%) | < 0.0001 | < 0.0001 |
TND (%) | 0.997 | |
Hemiplegia (%) | 0.053 | |
DSWI (%) | 0.706 | |
ARD (%) | < 0.0001 | < 0.0001 |
Pulmonary infection (%) | 0.009 | |
Tracheotomy (%) | 0.002 | |
Ventilation time (h) | 0.001 | |
Mean ± SD | ||
Median (IQR) | ||
ICU readmission (%) | < 0.0001 |
Author's roles & responsibilities | |
---|---|
ASA | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published |
FX | Substantial contributions to the conception or design of the work; final approval of the version to be published |
XW | Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved; final approval of the version to be published |