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Temporal evolution of risk profile and outcomes of percutaneous coronary intervention in patients with left ventricular dysfunction: results from the National Registry of Cardiovascular Interventions (CENIC)

BACKGROUND: Previous authors demonstrated better outcomes for patients with left ventricular dysfunction (LVD) undergoing coronary artery bypass grafting. However, it is not yet clear if those patients could benefit from percutaneous coronary intervention (PCI). This study aimed to evaluate the early PCI outcomes in patients with LVD undergoing PCI. METHODS: The database of the National Registry of Cardiovascular Interventions (CENIC) of the Brazilian Society of Hemodynamics and Interventional Cardiology (SBHCI) was used to analyze all PCI procedures in patients with LVD between 1999-2007. Patients were divided in two groups: group A (before 2002) and group B (after 2002). Clinical and angiographic characteristics and in-hospital outcomes were recorded and compared. Statistical analyses were performed using the chi-square test and Student's t test, and P < 0.05 was considered statistically significant. RESULTS: A total of 50,587 patients were treated by PCI (n = 12,783 in Group A and n = 37,804 in Group B). There was a significantly higher risk profile in group B, as well as a higher number of PCI in complex lesions and in patients with moderate and severe LVD. Rates of in-hospital mortality (2.4% vs. 1.6%; P < 0.001), acute myocardial infarction (0.9% vs. 0.5%; P < 0.001) and stroke (2.2% x 0.4%; P < 0.001) were reduced in patients treated after 2002. CONCLUSION: This study shows that adequate PCI results were obtained and maintained in hospitalized patients with LVD despite the progressive increase in the overall risk profile of these patients from 1999 to 2007.

Angioplasty, transluminal, percutaneous coronary; Stents; Risk factors; Ventricular function; Ventricular dysfunction, left


Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista - SBHCI R. Beira Rio, 45, 7o andar - Cj 71, 04548-050 São Paulo – SP, Tel. (55 11) 3849-5034, Fax (55 11) 4081-8727 - São Paulo - SP - Brazil
E-mail: sbhci@sbhci.org.br