▪ ABSTRACT
Introduction:
Recent studies have suggested the use of biological dressings made of aquatic animals as biomaterials in regenerative medicine since they demonstrate good adherence to the wound bed. The objective of this study was to evaluate the efficacy of Nile tilapia skin (Oreochromis niloticus) as an occlusive biological dressing in the management and treatment of second-degree burns in adults.
Methods:
This clinical study included 30 patients randomly treated with Nile tilapia skin (n = 15) or Aquacel Ag® silver-based hydrofiber dressing (n = 15).
Results:
The Nile tilapia skin yielded a similar mean treatment time (9.6 ± 2.4 days) to thatof the comparative material (10.7 ± 4.5 days). There was no statistically significantintergroup difference (p > 0.68) in pain during dressing changes. No disadvantage in pain wasnoted, as 66.7% of patients treated with Nile Tilapia skin reported a decrease in pain events Moreover, 60% of the patients treated with the Nile Tilapia skin did not require dressing replacement at any time during treatment. For the Aquacel AG® dressing, 53.3% of the patients required more than one dressing replacement.
Conclusion:
Our findings suggest that the Nile tilapia skin is as effective as an occlusive biological dressing. The average treatment time (complete wound healing) and pain reports during dressing changes were similar between groups. Furthermore, pain after and number of dressing exchanges (when performed) were not worse.
Keywords:
Burns; Occlusive dressings; Healing; Biological dressings; Cichlids
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