INTRODUCTION: PMMA is used as a permanent filler in the form of microspheres. There are several commercial applications; many of them are used indiscriminately. OBJECTIVE: Histological evaluation (of the applied place and organs) after PMMA filling in rats. METHODS: 60 Wistar rats were used; each received an application of 1 ml of PMMA (Meta-Crill®) in deep frame (near the occipital region). The euthanasia occurred in groups of 15 rats at 1, 3, 6 and 12 months after application. RESULTS: Presence of inflammatory infiltrate and fibrosis in the injected site, in addition to the reduced amount of PMMA in all samples. Foreign body reaction (FBR) granuloma type occurred in 3.3% of samples (2 mice). Statistical analysis was shown significant by Kruskal-Wallis. CONCLUSION: The PMMA used had a higher FBR and evident fibrosis in late samples, occurring FBR granuloma type. Although the PMMA seems safe, several complications can occur. Its use should be judicious, knowing that granulomas occur regardless of the technique.
Polymethyl methacrylate; Microspheres; Rats; Histology; Fibrosis; Foreign-Body Reaction
