Chemical composition and seasonal variability of the essential oils of leaves and morphological analysis of <i>Hyptis carpinifolia</i>

Sá, Stone de; Fiuza, Tatiana S.; Borges, Leonardo L.; Ferreira, Heleno D.; Tresvenzol, Leonice M.F.; Ferri, Pedro H.; Rezende, Maria H.; Paula, José R.

doi:10.1016/j.bjp.2016.05.011

Stone de Sá

Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil

Tatiana S. Fiuza

Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil

Leonardo L. Borges

Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil

Heleno D. Ferreira

Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil

Leonice M.F. Tresvenzol

Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil

Pedro H. Ferri

Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil

Maria H. Rezende

Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil

José R. Paula ^** Corresponding author. E-mail:jose_realino@ufg.br (J.R. Paula).

Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil

* Corresponding author. E-mail:jose_realino@ufg.br (J.R. Paula).

Conflicts of interest

The authors declare no conflicts of interest.

Authors' contributions

SS contributed in collecting plant sample, running the laboratory work. TSF drafted the paper and contributed to critical reading of the manuscript. HDF contributed in collecting plant sample and identification, confection of herbarium and morphological description of the species. LLB contributed to the statistical analyzes. MHR contributed in collecting plant sample and identification. LMFT contributed to critical reading of the manuscript. PHF contributed to chromatographic analysis. JRP designed the study, supervised the laboratory work contributed to biological and chemical studies, chromatographic analysis and critical reading of the manuscript. All the authors had read the final manuscript and approved the submission contributed to biological studies running the laboratory work, analysis of the data

Station	Date (2013)	Rainfall number of days	Total rainfall	Maximum temperature average	Minimum temperature average	Relative humidity average
83374	01/31	26	376.3	31	21	78.00
83374	02/28	19	117.1	34	21	74.75
83374	03/31	22	131	34	21	77.05
83374	04/30	6	99.4	33	21	72.26
83374	05/31	2	29.1	34	19	61.42
83374	06/30	4	8.3	33	19	64.25
83374	07/31	0	34.11	34	18	51.16
83374	08/31	0	35.78	35	19	42.39
83374	09/30	4	26.9	36	22	44.05
83374	10/31	13	114.9	35	22	65.66
83374	11/30	20	232	33	20	77.50
83374	12/31	27	315.5	32	21	80.36

Constituents	KI	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sept	Oct	Nov	Dec
Tricyclene	926	1.5	1.8	1.5	1.2	1.5	1.3	0.9	1.2	1.4	1.1	1.1	1.0
6-Methyl-heptan-2-ol	965	0.4	0.4	0.3	0.2	2.2	0.2	-	-	-	0.1	-	-
Sabinene	975	1.1	1.2	1.0	0.9	1.2	1.2	0.9	1.1	1.2	1.0	1.0	0.9
β-Pinene	979	4.5	5.3	4.1	3.1	4.5	4.2	2.9	4.2	5.1	3.1	3.1	3.1
1,8-Cineole	1031	55.5	51.8	43.9	39.6	47.2	52.6	47.7	57.4	61.8	48.1	51.2	54.5
γ-Terpinene	1059	0.1	0.1	-	-	-	-	0.1	0.1	0.1	-	0.1	0.2
cis-Sabinene hydrate	1070	-	-	-	-	-	-	0.1	0.1	0.1	0.2	0.2	0.1
Pinocarvone	1164	0.7	-	0.1	0.3	0.5	0.8	0.9	0.7	0.4	1.3	1.3	1.4
Terpinene-4-ol	1177	0.7	0.8	0.7	0.5	0.4	0.3	0.1	0.2	0.3	0.4	0.4	0.5
α-Copaene	1376	3.4	3.7	4.1	4.4	3.6	3.3	3.1	2.7	2.4	3.9	3.6	3.2
β-Bourbonene	1388	0.4	0.4	0.4	0.4	0.7	0.7	1.0	0.8	0.8	0.8	0.7	0.5
β-Caryophyllene	1419	6.1	5.9	8.2	10.0	6.7	7.7	9.2	6.7	4.4	9.9	8.4	6.5
Pinonic acid	1442	0.7	0.7	0.9	1.3	0.9	0.8	0.8	0.6	0.4	1.2	1.0	1.0
α-Humulene	1454	0.4	-	0.2	0.4	0.2	0.5	0.9	0.6	0.2	-	0.4	0.8
trans-Cadina-1(6),4-diene	1476	3.4	2.8	10.6	17.5	5.5	4.6	5.4	3.9	2.9	7.5	6.2	4.5
β-Selinene	1490	1.1	1.1	1.2	1.0	0.9	0.9	1.1	0.8	0.7	0.9	1.0	1.0
δ-Selinene	1492	1.6	1.7	1.9	2.0	1.5	1.3	1.5	1.2	1.1	1.6	1.4	1.5
γ-Cadinene	1513	1.0	1.0	1.2	1.4	1.1	1.0	1.2	0.9	0.7	0.8	1.0	1.2
cis-Cadinene ether	1553	0.3	-	-	-	0.3	0.4	-	-	0.5	-	-	-
Prenopsan-8-ol	1577	7.0	8.5	7.6	6.0	7.5	6.9	8.3	5.7	4.2	9.6	8.5	7.0
allo-Cedrol	1589	0.2	0.3	0.3	0.3	0.4	0.4	0.4	-	0.4	0.2	0.2	0.2
allo-Hedycaryol	1589	1.7	1.7	1.7	1.4	2.2	2.4	3.4	2.9	2.9	1.7	1.9	2.0
Rosifoliol	1600	0.5	0.8	0.6	0.4	0.7	0.5	0.6	0.4	0.3	0.7	0.6	0.5
epi-Cedrol	1619	0.8	0.8	0.6	0.7	0.1	-	-	-	-	0.3	0.8	-
Caryophylla-4(12),8(13)-dien-5α-ol	1640	0.3	0.5	0.3	0.2	0.5	0.4	0.5	0.3	0.3	0.3	0.2	0.3
Caryophylla-4(12),8(13)-dien-5β-ol	1640	0.7	1.1	0.9	0.6	-	1.0	1.2	0.9	0.9	0.7	0.6	0.8
Pogostol	1653	0.9	1.2	1.0	0.7	1.3	0.8	1.0	0.9	0.9	0.4	0.7	0.8
Khusinol (valerianol)	1658	1.7	2.5	1.9	1.2	2.1	1.8	1.6	1.7	2.2	1.2	1.3	1.4

Monoterpene hydrocarbons		7.5	8.9	6.9	5.3	9.4	6.9	4.7	6.6	7.9	5.4	5.3	5.1
Oxygenated monoterpenes		56.9	52.6	44.7	40.4	48.0	53.6	48.9	58.4	62.6	50.0	53.2	56.4
Sesquiterpene hydrocarbons		17.7	16.8	28.1	37.3	20.6	20.4	23.8	17.6	13.6	25.5	22.9	19.5
Oxygenated sesquiterpenes		13.9	17.1	13.6	11.2	14.7	14.1	16.6	12.8	12.3	14.8	14.5	12.7
Others		0.7	0.7	0.9	1.3	0.9	0.8	0.8	0.6	0.4	1.2	1.0	1.0

Total identified (%)		96.7	96.1	93.4	95.5	93.6	95.8	94.8	96.0	96.8	96.9	96.9	94.7

Yield (%)		1.8	2.0	2.0	1.9	2.0	1.6	1.3	1.3	1.2	1.6	1.6	1.8

[1] * Corresponding author. E-mail:jose_realino@ufg.br (J.R. Paula).

Brasil

Brasil

Chemical composition and seasonal variability of the essential oils of leaves and morphological analysis of Hyptis carpinifolia

ABSTRACT