Several plants with hypoglycemic properties have been used in folk medicine and traditional healing systems around the world. The purpose of this work was to evaluate the effects of Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, and Citrus aurantium L., Rutaceae, in a diabetic rat model to which the glucose levels were quantified every 24 hours by one month before of gastric administration of plants extract. Additionally, the cholesterol and triacylglycerides were evaluated using standard enzymatic techniques. The results showed that increases in the dose (0.5 to 1.5 g/kg) of Cnidoscolus chayamansa induce a high hypoglycemic effect (< 200 mg/dL). Another data indicate that Cnidoscolus chayamansa exerts variations in triacylglycerides (80-90 mg/dL) and cholesterol (88-96 mg/dL). Nevertheless, the administration of Citrus aurantium in the same doses was not sufficient for diminish the glucose levels (> 200 mg/dL). Other results, showed that Citrus aurantium exert changes in the concentration of triacylglycerides (158-172 mg/dL) and cholesterol (120-128 mg/dL). Finally, the administration of Ruta graveolens at dose of 0.5 mg/kg induces a hypoglycemic effect (< 200 mg/dL). Additionally, Ruta graveolens at dose of 0.5 to 1.5 g/kg induce variations in the triacylglycerides (110-120 mg/dL) and cholesterol (116-124 mg/dL) levels. In conclusion the administration of Cnidoscolus chayamansa it exerts hypoglycemic effects in a manner dose-dependent in comparison with both Ruta graveolens and Citrus aurantium. In addition, the plants evaluated induce changes in lipids levels dose-dependent.
Diabetes; Cnidoscolus chayamansa; Ruta graveolens; Citrus aurantium; Wistar
