Physical Performance Regarding Handgrip Strength in Women with Polycystic Ovary Syndrome

Kogure, Gislaine Satyko; Ribeiro, Victor Barbosa; Gennaro, Flávia Ganoa de Oliveira; Ferriani, Rui Alberto; Miranda-Furtado, Cristiana Libardi; Reis, Rosana Maria dos

doi:10.1055/s-0040-1718953

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Revista Brasileira de Ginecologia e Obstetrícia

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Sumário

Original Article • Rev. Bras. Ginecol. Obstet. 42 (12) • Dec 2020 • https://doi.org/10.1055/s-0040-1718953 copy

Physical Performance Regarding Handgrip Strength in Women with Polycystic Ovary Syndrome

Desempenho físico na força de preensão manual em mulheres com síndrome dos ovários policísticos

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective

The present study aimed to investigate the physical performance of handgrip strength (HGS) in women with polycystic ovary syndrome (PCOS).

Methods

A case-control study that included 70 women with PCOS and 93 agematched healthy women aged between 18 and 47 years with body mass index (BMI) between 18 Kg/m2-39.9 Kg/m2. The serum levels of total testosterone, androstenedione, insulin, estradiol, thyroid-stimulating hormone (TSH), prolactin, sex hormonebinding globulin (SHBG), and 17-hydroxyprogesterone (17-OHP) were measured. The free androgen index (FAI) and the homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. The body composition regions of interest (ROIs) were assessed by dual-energy X-ray absorptiometry (DXA), and the handgrip strength (HGS) was evaluated for both the dominant and the non-dominant hands with a manual Sammons Preston (Bolingbrook, IL, US) bulb dynamometer.

Results

Women with PCOS had high serum levels of total testosterone (p < 0.01), androstenedione (p = 0.03), and insulin (p < 0.01), as well as high FAI (p < 0.01) and HOMA-IR (p = 0.01) scores. Compared with the non-PCOS group, the PCOS group had greater total lean mass in the dominant hand (p < 0.03) and greater HGS in both the dominant and the non-dominant hands (p < 0.01). The HGS was correlated with lean mass (p < 0.01).

Conclusion

Women with PCOS have greater HGS. This may be associated with age and BMI, and it may be related to lean mass. In addition, the dominance effect on muscle mass may influence the physical performance regarding HGS in women with PCOS.

Keywords:
handgrip strength; polycystic ovary syndrome; body composition; hyperandrogenism

Variables	PCOS (N = 73)	non-PCOS (N = 97)	p-value
Variables	[median (SD)]	[median (SD)]	p-value
Estradiol (pg/mL)	115.3 (85.0)	120.3 (75.5)	0.71
Testosterone (ng/dL)	91.3 (36.4)	70.6 (28.7)	< 0.01
Free testosterone (nmol/L)	3.1 (1.2)	2.4 (0.9)	< 0.01
Androstenedione (ng/dL)	114.1 (34.7)	100.6 (42.1)	0.03
SHBG (nmol/L)	53.3 (38.5)	62.6 (36.5)	0.14
FAI	8.6 (5.7)	5.3 (4.0)	< 0.01
Glycemia (mg/dL)	102.0 (20.5)	97.5 (18.0)	0.15
Insulin (μIU/mL)	10.8 (13.6)	5.8 (5.1)	< 0.01
HOMA-IR	3.0 (4.3)	1.3 (1.3)	0.01
Lean mass – dominant arm (g)	2,079.5 (493.8)	1,916.8 (425.5)	0.03
Lean mass – non-dominat arm (g)	1,911.7 (557.1)	1,823.8 (392.4)	0.21
Total lean mass (g)	41,856.0 (7405.8)	36,589 (6,602.5)	0.04
Lean mass/height² (Kg/m²)	16.9 (2.8)	16.1 (2.4)	0.09
Appen. lean mass/height² (Kg/m²)	7.1 (1.3)	6.9 (1.1)	0.35

	Normal weight		Overweight		Obese
Variables	PCOS (n = 22)[median (SD)]	non-PCOS (n = 40)[median (SD)]	PCOS (n = 21)[median (SD)]	non-PCOS (n = 23)[median (SD)]	PCOS (n = 27)[median (SD)]	non-PCOS (n = 31)[median (SD)]
HGS – dominant hand	4,469.4 (840.3)	4,569.8 (845.8)	5,457.0 (1,010.4)*	4,486.1 (955.6)	5,551.7 (1,004.7)*	4,817.2 (1,084.8)
HGS – non-dominant hand	4,268.5 (970.9)	4,200.3 (802.2)	4,988.3 (920.8)*	4,335.5 (1135.4)	5,236.5 (986.9)*	4,439.6 (1,059.7)
Lean mass – dominant arm	1,601.2 (214.7)	1,646.7 (244.5)	1,996.1 (286.3)	1,895.4 (305.9)	2,508.2 (386.7)	2,334.1 (386.7)
Lean mass – non-dominat arm	1,510.7 (232.5)	1,590.2 (220.3)	1,816.5 (242.1)	1,808.9 (322.6)	2,289.5 (409.2)	2,182.1 (399.1)
Total lean mass	34,649.7 (3,486.5)	34,525.7 (3,120.6)	39,760.8 (3,187.6)	39,655.0 (3,647.0)	48,930.5 (5,188.7)	4,7017.6 (5,213.9)
Lean mass/height²	13.9 (1.1)	14.1 (1.1)	16.2 (1.1)	15.9 (1.2)	20.0 (1.5)*	18.8 (1.8)
Appen. lean mass /height²	5.7 (0.6)	6.0 (0.6)	6.9 (0.6)	6.8 (0.6)	8.6 (0.7)	8.2 (0.8)

Variable	Handgrip strength
	Dominant hand					Non-dominant hand
	Sum of square	df	Mean square	F value	Pr > F	Sum of square	df	Mean square	F value	Pr > F
Group	7,035,308.6	1	7,035,308.6	7.81	< 0.01	6,110,106.1	1	6,110,106.1	7.25	< 0.01
Body mass index (Kg/m²)	6,350,647.2	1	6,350,647.2	7.05	< 0.01	9,090,583.8	1	9,090,583.8	10.79	< 0.01
Age (years)	2,269,183.0	1	2,269,183.0	2.52	0.11	603,112.5	1	603,112.5	0.72	0.40
Testosterone (ng/dL)	79,826.2	1	79,826.2	0.09	0.76	281,617.1	1	281,617.1	0.33	0.56
Androstenedione (ng/dL)	3,538,715.9	1	3,538,715.9	3.93	0.04	6,899,149.3	1	6,899,149.3	8.19	< 0.01
Testosterone* Androstenedione	1,308,819.3	1	1,308,819.3	1.45	0.23	1,632,776.2	1	1,632,776.2	1.94	0.16

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[1] Address for correspondence Gislaine Satyko Kogure, PhD, Av. Bandeirantes 3.900, Monte Alegre, Ribeirão Preto, SP, 14049-900, Brazil (e-mail: gisatyko@gmail.com).