Monoclonal B CD5+ subclinical proliferation is related to a group of clinical or laboratory entities described in normal subjects (0.14%-5.5%), in normal members of families with cases of familial CLL (13.5%-18%) and in patients with monoclonal B lymphocytosis with lymphocyte counts of <5 x 10(9)/L and with <30% of lymphocytes in bone marrow. These three entities are now named monoclonal B-cell lymphocytosis. Additionally, there are cases that fulfill the diagnostic criteria for CLL but present with stable non-progressive disease and are also named as benign monoclonal B lymphocytosis, smoldering CLL, idiopathic persistent chronic lymphocytosis, and B-monoclonal lymphocytosis of undetermined significance.
Chronic lymphocytic leukemia; monoclonal B lymphocytosis