Currently one of the major problems in the serological selection of blood donors in respect to Chagas' disease is the high incidence of indeterminate reactions, making a large number of healthy individuals incorrectly diagnosed as seriously ill. This paper aims at evaluating the serological pattern of Chagas' disease of donors of the Uberaba Blood Center and also to propose mechanisms to reduce the rate of serological ineligibility due to suspicion of this disease. A retrospective study of the serological results of 79,729 samples of blood was carried out between January 2000 and December 2004. The results were analyzed according to the following variables: type of donor (first-time and multiple), gender and age (less than or equal to 30 or more than 30 years old). The statistical analysis was made using the chi-square test and a comparison of proportions (Z). Indeterminate results in respect to Chagas' disease among first-time donors were significantly higher than those of multiple donations with p < 0.0001. As for age, the proportion of positivity in the over 30-year-old group was significantly higher to that of the under or equal to 30-year-old group (p < 0.0001). The high number of indeterminate reactions at this center is in accordance with recent studies, highlighting the need of implementing serological tests with 100% specificity or the use of practical and fast confirmation tests to be routinely introduced in hemotherapy services, reducing the unnecessary rejection of blood bags.
Transfusional Chagas' disease; indeterminate serological reactions; sensitivity and specificity of serological tests
