In middle of 90th decade, corneal collagen crosslinking photo-induced by riboflavin was considered as a new therapeutical modality in the treatment of keratoconus. Since then, the clinical effect of this procedure in laboratorial environment and clinical assays had been studied. In this article, we revise the literature already published until the moment in order to display on the procedure and its effects.
Keratoconus/therapy; Collagen/radiation effects; Riboflavin/therapeutic use; Ultraviolet therapy; Phototherapy; Ultraviolet rays; Crosslinking reagents