Association between Knee Osteoarthritis and Metabolic Syndrome in Non-Institutionalized Elderly Patients

doi:10.1055/s-0040-1701281

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Sumário

Original Articles, Knee • Rev. bras. ortop. 55 (3) • May-Jun 2020 • https://doi.org/10.1055/s-0040-1701281 copy

Association between Knee Osteoarthritis and Metabolic Syndrome in Non-Institutionalized Elderly Patients^* * Work developed at Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.

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Abstract

Objective

This study aimed to analyze the association between knee osteoarthritis (OA) and metabolic syndrome (MS) in non-institutionalized elderly patients.

Methods

A cross-sectional, randomized study, drawn from a probabilistic cluster study conducted with 416 elderly people from a Family Health Unit (USF, in the Portuguese acronym) of our municipality. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III), and OA according to the KellgrLawrence (KL) scale (≥ 2).

Results

For the statistical analysis, we performed an exploratory data analysis, Mann-Whitney or Chi-Squared tests and univariate and multivariate logistic regressions, with significance level of p < 0.05; the concordance between the evaluators was verified through the Kappa coefficient. There was an association between OA and body mass index (BMI) (p = 0.0021) and between OA and waist circumference (WC) (p < 0.001; odds ratio [OR] = 3.524). There was no significant association between OA and the number of metabolic components nor with SM itself.

Conclusion

We conclude that knee OA is associated with WC, regardless of weight, and that the increase in its measure reflects a greater chance of MS in non-institutionalized elderly patients.

Keywords
osteoarthritis; metabolic syndrome; obesity; aging; health promotion

Variables	N^a a number of subjects.	%	Mean ± SD^b b standard deviation.
Gender
Female	104	57.1
Male	78	42.9
Total	182	100.0
Age	182		73.0 ± 5.6
BMI (kg/cm²)	182		27.9 ± 4.8

	Knee Osteoarthritis
Variable	No OA	With OA	Total	P-value
Age (mean ± SD) Total	72.3 ± 5.6 106	73.9 ± 5.5 76	73.0 ± 5.6 182	0.0571^a a Mann-Whitney test.
Gender				0.6332^b b Chi-square test.
Female	59 (55.7%)	45 (59.2%)	104 (57.1%)
Male	47 (44.3%)	31 (40.8%)	78 (42.9%)
Total	106	76	182
Waist circumference				< 0.0001 ^b b Chi-square test.
Within the boundary	61 (58.0%)	21 (27.0%)	82 (45.0%)
Out of bounds	45 (42.0%)	55 (73.0%)	100 (55.0%)
Total	106	76	182
Blood pressure				0.4808^b b Chi-square test.
Within the boundary	18 (17.0%)	10 (13.2%)	28 (15.4%)
Out of bounds	88 (83.0%)	66 (86.8%)	154 (84.6%)
Total	106	76	182
Triglycerides				0.8274^b b Chi-square test.
Within the boundary	51 (49.0%)	39 (50.7%)	90 (49.4%)
Out of bounds	55 (51.0%)	37 (49.3%)	92 (50.6%)
Total	106	76	182
HDL-cholesterol				0.8881^b b Chi-square test.
Within the boundary	71 (67.7%)	51 (66.7%)	122 (67.0%)
Out of bounds	35 (32.3%)	25 (33.3%)	60 (33.0%)
Total	106	76	182
Fasting glycemia				0.0937^b b Chi-square test.
Within the boundary	61 (57.5%)	53 (69.7%)	114 (62.6%)
Out of bounds	45 (42.5%)	23 (30.3%)	68 (37.4%)
Total	106	76	182

Knee osteoarthritis
Metabolic syndrome	No OA	With OA	P-value
Absence MS (< 3 components)	49.5%	46.3%	0.6924^a a Chi-square test.
Presence MS (3 components)	50.5%	53.7%

Sociedade Brasileira de Ortopedia e Traumatologia Al. Lorena, 427 14º andar, 01424-000 São Paulo - SP - Brasil, Tel.: 55 11 2137-5400 - São Paulo - SP - Brazil
E-mail: rbo@sbot.org.br

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[1] Address for correspondence Maura Fernandes Franco, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126 - Cidade Universitária Zeferino Vaz, Campinas, SP 13083-887, Brasil (e-mail: mauraffranco@gmail.com).

Simple analysis (univariate)
Factor	OR	95%CI (OR)	P-value
Waist circumference	3.729	1.949 7.133	< 0.0001
Blood pressure	1.350	0.585 3.116	0.4819
Triglycerides	0.935	0.510 1.714	0.8275
HDL- cholesterol	1.048	0.543 2.025	0.8880
Fasting glycemia	0.588	0.316 1.097	0.0950
Multiple analysis (multivariate)
Factor	OR	IC95% (OR)	P-value
Waist circumference	3.524	1.794 6.921	0.0003

Brasil

Brasil

Association between Knee Osteoarthritis and Metabolic Syndrome in Non-Institutionalized Elderly Patients* * Work developed at Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Abstract

Objective

Methods

Results

Conclusion

Association between Knee Osteoarthritis and Metabolic Syndrome in Non-Institutionalized Elderly Patients^* * Work developed at Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.