Castleman's disease (CD) is rare nonmalignant lymphoproliferative illness, of unknown etiology, clinically characterized by isolated or multiple adenomegalies, associated or not with systemic symptoms such as fever and weight loss. These symptoms can lead to a wrong diagnosis of autoimmune illness and the differential diagnosis must be made through histological examination of involved lymph nodes, which shows, in the case of CD, a pattern of plasma cells with hyaline infiltration. A case of a woman of 24-year-old, who initially presented fever, polyarthritis and skin rash, suggestive adult-onset Still's disease is reported; the histological examination confirmed the diagnosis of Castleman's disease.
Castleman's disease; adult-onset Still´s disease; lymphoproliferative disease
