ABSTRACT
A main challenge in the clinical management of prostate cancer is to identify which tumor is aggressive and needs invasive treatment. Thus, being able to predict which cancer will progress to biochemical recurrence is a great strategy to stratify prostate cancer patients. With that in mind, we created a mathematical formula that takes into account the patients clinical and pathological data resulting in a quantitative variable, called PSA density of the lesion, which has the potential to predict biochemical recurrence. To test if our variable is able to predict biochemical recurrence, we use a cohort of 219 prostate cancer patients, associating our new variable and classic parameters of prostate cancer with biochemical recurrence. Total PSA, lesion weight, volume and classic PSA density were positively associated with biochemical recurrence (p<0.05). ISUP score was also associated with biochemical recurrence in both biopsy and surgical specimen (p<0.001). The increase of PSA density of the lesion was significantly associated with the biochemical recurrence (p=0.03). Variables derived from the formula, PSA 15% and PSA 152, were also positive associated with the biochemical recurrence (p=0.01 and p=0.002 respectively). Logistic regression analysis shows that classic PSA density, PSA density of the lesion and total PSA, together, can explain up to 13% of cases of biochemical recurrence. PSA density of the lesion alone would have the ability to explain up to 7% of cases of biochemical recurrence. In conclusion, this new mathematical approach could be a useful tool to predict disease recurrence in prostate cancer.
Keywords:
Recurrence; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms
RESUMO
Um dos principais desafios no manejo clínico do câncer de próstata é identificar qual tumor é agressivo e precisa de tratamento invasivo. Assim, ser capaz de prever qual irá progredir para recorrência bioquímica é uma ótima estratégia para estratificar pacientes com câncer de próstata. Pensando nisso, criamos uma fórmula matemática que leva em consideração os dados clínicos e patológicos resultando em uma variável quantitativa, denominada densidade de PSA da lesão, que tem potencial para predizer recidiva bioquímica. Para testar se nossa variável é capaz de predizer recorrência bioquímica, usamos uma coorte de 219 pacientes com câncer de próstata, associando nossas variáveis e parâmetros clássicos como a recorrência bioquímica. PSA total, peso da lesão, volume e densidade de PSA clássico foram associados com recorrência bioquímica (p<0,05). O escore ISUP também foi associado à recorrência bioquímica na biópsia e na amostra cirúrgica (p<0,001). O aumento da densidade do PSA da lesão foi significativamente associado à recidiva bioquímica (p=0,03). As variáveis ??derivadas da fórmula, PSA 15% e PSA 152, também foram associadas positivamente à recorrência bioquímica (p=0,01 e p=0,002 respectivamente). A análise de regressão logística mostra que a densidade do PSA clássico, do PSA da lesão e PSA total, juntos, podem explicar até 13% dos casos de recorrência. A densidade de PSA da lesão por si só poderia explicar até 7% dos casos de recorrência. Em conclusão, esta nova abordagem matemática pode ser uma ferramenta útil para prever a recorrência da doença no câncer de próstata.
Palavras-chave:
Recidiva; Prognóstico; Neoplasias da Próstata; Antígeno Prostático Específico
INTRODUCTION
Prostate cancer (PCa) is the second most common neoplasm and the fifth leading cause of cancer death in men11 Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30. doi: 10.3322/caac.21590.
https://doi.org/10.3322/caac.21590...
. Furthermore, predictions indicate that the number of PCa cases has been increasing and, together with this increase in incidence, the number of operations to treat the disease has increased considerably22 Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi: 10.3322/caac.21492.
https://doi.org/10.3322/caac.21492....
3 Brawley OW. Prostate cancer epidemiology in the United States. World J Urol. 2012;30(2):195-200. doi: 10.1007/s00345-012-0824-2.
https://doi.org/10.1007/s00345-012-0824-...
-44 Rawla P. Epidemiology of Prostate Cancer. World J Oncol. 2019;10(2):63-89. doi: 10.14740/wjon1191.
https://doi.org/10.14740/wjon1191...
. The widespread use of prostate specific antigen (PSA) has increased the detection rates of this cancer at earlier stages. However, up to 20% of clinically localized cases may present disease recurrence after local radical treatment in a 10 year follow-up period55 Zerbib M, Zelefsky MJ, Higano CS, Carroll PR. Conventional treatments of localized prostate cancer. Urology. 2008;72(6 Suppl):S25-35. doi: 10.1016/j.urology.2008.10.005.
https://doi.org/10.1016/j.urology.2008.1...
.
This phenomenon occurs because current clinical and pathological parameters fail to determine accurate prognosis in many cases66 Berger AP, Spranger R, Kofler K, Steiner H, Bartsch G, Horninger W. Early detection of prostate cancer with low PSA cut-off values leads to significant stage migration in radical prostatectomy specimens. Prostate. 2003;57(2):93-8. doi: 10.1002/pros.10278.
https://doi.org/10.1002/pros.10278...
. In this regard, many efforts are concentrated on finding predictors of biochemical recurrence (i.e. the increase of serum PSA after treatment).
In the current study, we evaluate whether the present surgical specimen information can be a predictor of biochemical recurrence. Thus, we have created a formula to assess the PSA density of the lesion, trying to offer a way to include some data from patients, which have been neglected by current methods that can predict biochemical recurrence.
METHODS
Experimental Design
This is a retrospective longitudinal analytical study that was carried out after approval by the Ethics and Research Committee of the Hospital das Clínicas of the University of São Paulo (under the number: 1.955.609).
Initially, 372 male patients, aged between 43 and 81 years, from a private clinic of a single surgeon (CCP), operated between September 2009 and June 2019 were evaluated. However, 76 patients were excluded because they were regularly followed up according to the protocol. Another 64 patients were excluded because they did not present an exact description of the weight of the lesion or the weight of the prostate in the pathological exam. Thirteen patients were excluded for having hormonal block prior to surgery. Thus, the population of the present study was composed of 219 patients.
The PSA density of the lesion of all the patients was calculated and at the end, this calculation was correlated with the presence of tumor recurrence. We have considered biochemical recurrence the finding of PSA values greater than 0.2ng/dL in two consecutive postoperative samples. The first postoperative PSA measurement occurred eight weeks after the operation. Patients with values greater than or equal to 0.2ng/dL underwent a new confirmatory dosage77 Roach M, Hanks G, Thames H, Schellhammer P, Shipley WU, Sokol GH, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006;65(4):965-74. doi: 10.1016/j.ijrobp.2006.04.029.
https://doi.org/10.1016/j.ijrobp.2006.04...
.
Evaluation of the PSA density of the lesion
To analyze the density of the PSA we used anatomopathology information. We estimated the weight of the primary neoplastic lesion as well as the multicentric lesions using the method standardized by the College of American Pathologists. This method defines that the specimen from radical prostatectomy can have its neoplasia percentage quantified by: careful visualization, being complemented by objective data such as measures of tumor dimensions and; the number of blocks involved by the tumor in relation to the number of total blocks. It is important to highlight that the pathology analysis of the samples was not necessarily performed by the same pathologist88 Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, et al. EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol. 2011;59(1):61-71. doi: 10.1016/j.eururo.2010.10.039.
https://doi.org/10.1016/j.eururo.2010.10...
,99 Renshaw AA, Richie JP, Loughlin KR, Jiroutek M, Chung A, D'Amico AV. Maximum diameter of prostatic carcinoma is a simple, inexpensive, and independent predictor of prostate-specific antigen failure in radical prostatectomy specimens. Validation in a cohort of 434 patients. Am J Clin Pathol. 1999;111(5):641-4. doi: 10.1093/ajcp/111.5.641.
https://doi.org/10.1093/ajcp/111.5.641...
.
We calculated the difference between the weight of the prostate (WP) and the weight of the neoplastic lesion (WL
Firstly, we calculated the weight of the non-neoplastic (benign) portion of the prostate (BP) with the data obtained from the complete anatomopathology examination of each patient (which systematically reports the prostatic weight and the estimated percentage of the prostatic volume represented by tumor tissue). Differences between the weight of the prostate (WP) and the weight of the neoplastic lesion (WN), were assessed according to the following formula: BP = WP - WN.
Then, we performed the calculation of the PSA produced only by the benign portion of the prostate (PSABP). We considered the PSA density of 15% as the cutoff to estimate PSA production by the non-neoplastic portion of the prostate. This value of 0.15 is based on the cutoff of the predictor called classic prostate PSA density, traditionally used as a predictor for patient selection for prostate biopsy and as a parameter for the management of patients under active surveillance. This value is obtained by dividing the total PSA value and the prostate volume, then the following formula was used: PSABP = 0.15 x BP33 Brawley OW. Prostate cancer epidemiology in the United States. World J Urol. 2012;30(2):195-200. doi: 10.1007/s00345-012-0824-2.
https://doi.org/10.1007/s00345-012-0824-...
4 Rawla P. Epidemiology of Prostate Cancer. World J Oncol. 2019;10(2):63-89. doi: 10.14740/wjon1191.
https://doi.org/10.14740/wjon1191...
-55 Zerbib M, Zelefsky MJ, Higano CS, Carroll PR. Conventional treatments of localized prostate cancer. Urology. 2008;72(6 Suppl):S25-35. doi: 10.1016/j.urology.2008.10.005.
https://doi.org/10.1016/j.urology.2008.1...
. Subsequently, we calculated the PSA produced by the neoplastic portion (PSA of the lesion), using the formula: PSA of the lesion = total PSA - PSABP.
After calculating the PSA of the lesion, a correction factor was added, since there is a possibility that the PSA calculation value of the lesion is negative. Therefore, this value was squared in order to correct this lesion, generating a PSA value - fifteen squared (PSA15²): PSA15² = (PSA of the lesion)². Lastly, the PSA density of the neoplastic lesion was calculated (DNL) by the division between PSA15² and WL (DNL = PSA15²/WN).
The steps can be simplified by performing the calculation using the formula:
Application of the formula
Therefore, we propose a way to include patient profiles that are commonly neglected by current methods of relapse predictors. For the best elucidation of how these data are used, we demonstrate three models of prostate, represented with data from patients who participated in our study:
Example 1: patient with total PSA of 4.4ng/dL, prostate volume of 57.6cm3. The anatomopathology evidence showed that the prostate weight was 50 grams and 5% of the prostate gland was occupied by the neoplasm (i.e.: lesion weight: 2.5g), with a classic PSA density of 0.08 (considered low, predictor of low aggressiveness) and DNL of 2.96 (new parameter, considered high, bearing a possible predictor of aggressiveness). The patient in question evolved with biochemical recurrence. It is a patient model with a potential small aggressive lesion that could induce the production of a large amount of PSA per gram of injury. Therefore, this is a profile of a patient with a greater possibility of biochemical recurrence, susceptible to being neglected by current predictors (Figure 1A).
Illustration of the prostate models. The larger ellipse represents the entire prostate and the smaller ellipse represents the neoplastic lesion. The blue tone estimates the increase of produced PSA (the lighter, the lower the PSA production) by the fabric in question. A) Small lesion with high DNL. B) Larger lesion with low DNL. C) Lesion with very low DNL.
Detailed calculations of example 1:
Example 2: patient with total PSA of 6.0ng/dL, prostate with a volume of 34cm3, prostate weight of 35g and 10% of the prostate volume occupied by the neoplasm, classic PSA density of 0.17 (considered high, predictor of aggressiveness) and DNL of 0.46 (new parameter, considered low, with a possible predictor of little aggressiveness). The patient in question did not present biochemical recurrence. It is a patient model that presents a potential little aggressive lesion that could induce the production of a small amount of PSA per gram of lesion. Therefore, this is a profile of a patient with less chance of biochemical recurrence, susceptible to being treated with unnecessarily adjuvant therapy, based on currently available predictors (Figure 1B).
Example 3: patient with total PSA of 3.1ng/ dL, prostate with a volume of 40cm3, prostate weight of 40g, 10% of the prostate volume occupied by the neoplasia, classic PSA density of 0.07 (considered low, predictor of low aggressiveness) and DNL of 1.32 (new parameter, considered high, bearing a possible predictor of aggressiveness). The patient in question evolved with biochemical recurrence. This is a patient model with a likely aggressive injury that could cause little or no increase in PSA levels per gram of injury. Therefore, this is a profile of a patient with a greater possibility of biochemical recurrence, susceptible to being neglected by current predictors (Figure 1C).
The study was approved by the local ethics committee under the number 64119817.6.0000.0065.
Statistical analysis
We calculated a post hoc sample power, using the G Power 3.1 program based the determination coefficient (r2) obtained from the models generated from the multiple Logistic Regression. We considered the sampling error of 5% and a 95% confidence interval, and the minimum significant sample for the study was 68 patients.
The collected data were initially plotted on a spreadsheet using the Microsoft Excel software (2013) and later analyzed with the aid of the SPSS software (23.0). The characterization of the patient’s profile was performed by absolute (n) and relative (%) frequency for categorical variables. Mean, standard deviation, median, minimum, maximum and interquartile range for continuous variables were considered. In this study, the normality was tested by the Shapiro-Wilk test. The comparison of the postoperative outcomes with categorical exploratory variables was performed using the Pearson chi-square and Post hoc chi-square test. The agreement between ISUP in surgical specimen and ISUP in biopsies was made using the Kappa test (data no shown). Regarding continuous variables, analyzes were performed using Student’s t and Mann-Whitney tests. In order to explore the contribution of continuous and categorical exploratory variables under the postoperative outcome, multiple logistic regression was performed using the conditional step-forward method. In all analyzes, the level of significance adopted was 5% (p<0.05).
RESULTS
The patients’ clinical variables are shown in Tables 1 and 2. The average age was 62.51± 7.60 years. We observed a biochemical recurrence rate of 18.3%.
Table 3 depicts the data regarding the comparison between patients with or without biochemical recurrence. The median age of patients with biochemical recurrence was 61.5 years and of those without biochemical recurrence was 63.0 years (p=0.18). Prostate weight and volume was not associated with biochemical recurrence (p=0.47 and p= 0.56 respectively).
The total PSA values were different between patients who had recurrence or not (6.29 vs 5.00 respectively, p=0.01). The increase of lesion and weight volume was associated with biochemical recurrence (p=0.02 and p=0.03 respectively). The Classic PSA density was also positively associated with biochemical recurrence (p=0.005)
The new developed PSA density of the lesion was assessed, and we found that the increase of this variable was significantly correlated with the biochemical recurrence (p=0.03). PSA 15% and PSA 1522 Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi: 10.3322/caac.21492.
https://doi.org/10.3322/caac.21492....
were also positively associated with the biochemical recurrence (p=0.01 and p=0.002 respectively)
Additionally, the ISUP score between the group with or without biochemical recurrence (Figure 2) was evaluated, and the increase in the ISUP score was associated with the biochemical recurrence in both biopsy and surgical specimens of PC samples (p<0.001).
Comparison ISUP score between biopsy and surgical specimens in patients with or without biochemical recurrence. *Mann-Whitney test.
Finally, the multiple logistic regression (Table 4) indicated that the classic variables as PSA density, PSA density of the lesion and total PSA, together, can explain up to 13% of cases of biochemical recurrence. PSA density of the lesion, according to this model, would have the ability to explain up to 7% of cases of biochemical recurrence.
DISCUSSION
The curative treatment for PCa has highly been carried out in recent decades1010 Sebesta EM, Anderson CB. The Surgical Management of Prostate Cancer. Semin Oncol. 2017;44(5):347-57. doi: 10.1053/j.seminoncol.2018.01.003.
https://doi.org/10.1053/j.seminoncol.201...
. Robotic radical prostatectomy is certainly one of the greatest advances. However, treatment is not free from adverse effects and there is always the possibility of an unfavorable outcome despite the use of the best available methods. Overtreatment is a real problem for PCa, thus being able to predict those patients who need invasive treatment, and those who have an indolent disease is highly necessary1111 Sanda MG, Cadeddu JA, Kirkby E, Chen RC, Crispino T, Fontanarosa J, et al. Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part I: Risk Stratification, Shared Decision Making, and Care Options. J Urol. 2018;199(3):683-90. doi: 10.1016/j.juro.2017.11.095.
https://doi.org/10.1016/j.juro.2017.11.0...
. In addition, the indiscriminate use of PSA levels has been associated with a high rate of overdiagnosis and excessive treatment1212 Hugosson J, Carlsson S, Aus G, Bergdahl S, Khatami A, Lodding P, et al. Mortality results from the Göteborg randomised population-based prostate-cancer screening trial. Lancet Oncol. 2010;11(8):725-32. doi: 10.1016/S1470-2045(10)70146-7.
https://doi.org/10.1016/S1470-2045(10)70...
13 Andriole GL, Crawford ED, Grubb RL, Buys SS, Chia D, Church TR, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360(13):1310-9. doi: 10.1056/NEJMoa0810696.
https://doi.org/10.1056/NEJMoa0810696...
-1414 Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360(13):1320-8. doi: 10.1056/NEJMoa0810084.
https://doi.org/10.1056/NEJMoa0810084...
.
Normally, after treatment, the PSA levels of PCa patients drop to zero. Biochemical recurrence is a phenomenon in which the PSA increases again, indicating the disease recurrence1515 Venclovas Z, Jievaltas M, Milonas D. Significance of Time Until PSA Recurrence After Radical Prostatectomy Without Neo- or Adjuvant Treatment to Clinical Progression and Cancer-Related Death in High-Risk Prostate Cancer Patients. Front Oncol. 2019;9:1286. doi: 10.3389/fonc.2019.01286.
https://doi.org/10.3389/fonc.2019.01286...
. Therefore, being able to predict biochemical recurrence is a great strategy to early identify aggressive tumors.
In this study, we present the PSA Density of the lesion, a new parameter that is intended to help predict biochemical recurrence. Other authors have tried to use derivations of PSA density66 Berger AP, Spranger R, Kofler K, Steiner H, Bartsch G, Horninger W. Early detection of prostate cancer with low PSA cut-off values leads to significant stage migration in radical prostatectomy specimens. Prostate. 2003;57(2):93-8. doi: 10.1002/pros.10278.
https://doi.org/10.1002/pros.10278...
; however, no studies were found that used the same criteria used in this protocol. Therefore, it is an original parameter. It is derived from a calculation that takes into account the total PSA, the weight of the prostate and the weight of the neoplastic lesion. We also tested other new parameters such as and PSA of the lesion 15% and PSA of the lesion15², used in the calculation of the Lesion Density. Other already established parameters, such as total PSA, classic density of PSA, fraction of the prostate affected by the tumor, pathology signs of extra-prostatic extension, ISUP graduation, prostate weight, prostate volume and lesion weight were used.
DNL is an estimate of the increase in PSA concentration caused by the gram of the neoplastic lesion. The other existing derivative methods of PSA do not take into account their particular specific correlation with the weight of the neoplastic lesion. Therefore, it is an attempt to consider that there may be small lesions, but with the capacity to cause a relative high production of PSA or even large neoplastic lesions that do not significantly increase PSA. These would be, at first, less aggressive, while those would have greater power to cause a clinically unfavorable evolution.
It is also proposed, with this calculation model, to correct part of the distortions that occurs, for example, in patients with poorly differentiated lesions and insignificant PSA production, which would lead patients with this profile to have their disease underestimated.
The presented results reveal that the proposed new parameter has a statistically significant correlation with the outcome, both in univariate analysis and in multiple logistic regression. The clinical applicability of this new parameter would be for the selection of patients with a higher risk of biochemical recurrence. For these patients, adjuvant treatments would be considered more seriously instead of waiting for the patient to present biochemical recurrence to administer rescue therapies.
The pathology graduation according to the ISUP criteria showed a positive association when the outcome of biochemical recurrence was considered. Other authors have also identified the pathology graduation as a predictor of biochemical recurrence1616 Pompe RS, Bandini M, Preisser F, Marchioni M, Zaffuto E, Tian Z, et al. Contemporary approach to predict early biochemical recurrence after radical prostatectomy: update of the Walz nomogram. Prostate Cancer Prostatic Dis. 2018;21(3):386-93. doi: 10.1038/s41391-018-0033-1.
https://doi.org/10.1038/s41391-018-0033-...
. In a recent study, the rate of biochemical recurrence in 1,754 men who underwent radical prostatectomy and concluded that ISUP score was assessed as the most important predictor for biochemical recurrence in high-risk patients1515 Venclovas Z, Jievaltas M, Milonas D. Significance of Time Until PSA Recurrence After Radical Prostatectomy Without Neo- or Adjuvant Treatment to Clinical Progression and Cancer-Related Death in High-Risk Prostate Cancer Patients. Front Oncol. 2019;9:1286. doi: 10.3389/fonc.2019.01286.
https://doi.org/10.3389/fonc.2019.01286...
. Our data are in agreement with the literature in this topic.
The total PSA value was confirmed as an independent predictor of biochemical recurrence, both in the univariate analysis and in multiple logistic regression, which is widely supported by the literature1717 Narita S, Mitsuzuka K, Tsuchiya N, Koie T, Kawamura S, Ohyama C, et al. Reassessment of the risk factors for biochemical recurrence in D'Amico intermediate-risk prostate cancer treated using radical prostatectomy. Int J Urol. 2015;22(11):1029-35. doi: 10.1111/iju.12898.
https://doi.org/10.1111/iju.12898...
18 Freedland SJ, Wieder JA, Jack GS, Dorey F, deKernion JB, Aronson WJ. Improved risk stratification for biochemical recurrence after radical prostatectomy using a novel risk group system based on prostate specific antigen density and biopsy Gleason score. J Urol. 2002;168(1):110-5.-1919 Hamada R, Nakashima J, Ohori M, Ohno Y, Komori O, Yoshioka K, et al. Preoperative predictive factors and further risk stratification of biochemical recurrence in clinically localized high-risk prostate cancer. Int J Clin Oncol. 2016;21(3):595-600. doi: 10.1007/s10147-015-0923-3.
https://doi.org/10.1007/s10147-015-0923-...
. The classic density of PSA also showed a statistically significant correlation and this is in agreement with what we found in our literature review1717 Narita S, Mitsuzuka K, Tsuchiya N, Koie T, Kawamura S, Ohyama C, et al. Reassessment of the risk factors for biochemical recurrence in D'Amico intermediate-risk prostate cancer treated using radical prostatectomy. Int J Urol. 2015;22(11):1029-35. doi: 10.1111/iju.12898.
https://doi.org/10.1111/iju.12898...
,1818 Freedland SJ, Wieder JA, Jack GS, Dorey F, deKernion JB, Aronson WJ. Improved risk stratification for biochemical recurrence after radical prostatectomy using a novel risk group system based on prostate specific antigen density and biopsy Gleason score. J Urol. 2002;168(1):110-5.. In a series of 784 patients undergoing robotic radical prostatectomy, it was identified that the density of PSA is an independent predictor of biochemical recurrence in patients undergoing treatment with a curative purpose2020 Hashimoto T, Yoshioka K, Nagao G, Nakagami Y, Ohno Y, Horiguchi Y, et al. Prediction of biochemical recurrence after robot-assisted radical prostatectomy: analysis of 784 Japanese patients. Int J Urol. 2015;22(2):188-93. doi: 10.1111/iju.12624.
https://doi.org/10.1111/iju.12624...
.
We analyzed the potential correlation of the prostate weight provided by the pathology examination and did not find any significant association. When we considered the prostate volume measured by preoperative ultrassonograpy and tried to correlate it with the outcome of biochemical recurrence, we did not find any statistically significant values. In contrast, other authors have already demonstrated the association between biochemical recurrence and prostate volume1919 Hamada R, Nakashima J, Ohori M, Ohno Y, Komori O, Yoshioka K, et al. Preoperative predictive factors and further risk stratification of biochemical recurrence in clinically localized high-risk prostate cancer. Int J Clin Oncol. 2016;21(3):595-600. doi: 10.1007/s10147-015-0923-3.
https://doi.org/10.1007/s10147-015-0923-...
. Evaluating 5,637 patients who underwent radical prostatectomy, a the authors concluded that intermediate-risk patients with lower-volume prostates are more likely to develop biochemical recurrence, which indicates that the relationship between volume and biochemical recurrence may be more complex than it is thought2121 Moschini M, Gandaglia G, Suardi N, Fossati N, Cucchiara V, Damiano R, et al. Importance of prostate volume in the stratification of patients with intermediate-risk prostate cancer. Int J Urol. 2015;22(6):555-61. doi: 10.1111/iju.12748.
https://doi.org/10.1111/iju.12748...
.
In the present work, we set out to test the capacity of a new predictor of biochemical recurrence which is the PSA Density of the lesion. Other authors had already tried to use derivations of the PSA density. However, we did not find studies that used the same criteria of our study to predict biochemical recurrence2222 Ku JH, Moon KC, Cho SY, Kwak C, Kim HH. Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy: a new predictor of biochemical recurrence in localized or locally advanced prostate cancer. Asian J Androl. 2011;13(2):248-53. doi: 10.1038/aja.2010.152.
https://doi.org/10.1038/aja.2010.152...
. The PSA density of the lesion is an estimate of the increase in PSA concentration caused by each gram of the neoplastic lesion. It is an attempt to take into account that there may be small lesions, but with the capacity to cause a relatively high PSA production, or even large neoplastic lesions that do not significantly increase PSA. These would, in theory, be less aggressive, while those would have greater power to cause a clinically unfavorable evolution.
We also tried with this model to correct part of the distortions that occur, for example, when patients who have poorly differentiated lesions and insignificant PSA production have their diagnosis underestimated. The presented results reveal that the proposed new parameter has a statistically significant correlation with the outcome of biochemical recurrence, both in univariate analysis and in multiple logistic regression.
In the context of the immediate postoperative period, we are often faced with the need to decide whether or not the patient would benefit from undergoing any adjuvant treatment either radiotherapy, hormonal block or even chemotherapy2323 Pan J, Chi C, Qian H, Zhu Y, Shao X, Sha J, et al. Neoadjuvant chemohormonal therapy combined with radical prostatectomy and extended PLND for very high risk locally advanced prostate cancer: A retrospective comparative study. Urol Oncol. 2019;37(12):991-8. doi: 10.1016/j.urolonc.2019.07.009.
https://doi.org/10.1016/j.urolonc.2019.0...
. This decision is critical, since all adjuvant therapies have side effects. Our new predictor can help this decision, identifying more aggressive tumors and, therefore, which ones need adjuvant therapies.
Another important point is that the PSA density of the lesion uses data that are normally collected during the diagnosis of PCa. This is important because despite the relatively low rate of prediction (explaining 7% of cases of biochemical recurrence in our cohort), it can help in the prognosis of the disease without bringing any type of harm to the patient, such as a new invasive exam for example.
The usefulness of this new parameter would be to help decide whether to indicate or not adjuvant therapy for patients with a higher risk of biochemical recurrence. The main disadvantage of this work is that it is retrospective analysis. Therefore, mainly prospective studies would be necessary to consolidate the proposed thesis.
REFERENCES
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» https://doi.org/10.3322/caac.21590 -
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» https://doi.org/10.3322/caac.21492. -
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» https://doi.org/10.1007/s00345-012-0824-2 -
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» https://doi.org/10.14740/wjon1191 -
5Zerbib M, Zelefsky MJ, Higano CS, Carroll PR. Conventional treatments of localized prostate cancer. Urology. 2008;72(6 Suppl):S25-35. doi: 10.1016/j.urology.2008.10.005.
» https://doi.org/10.1016/j.urology.2008.10.005 -
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Funding source:
no.
Publication Dates
-
Publication in this collection
11 Oct 2021 -
Date of issue
2021
History
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Received
28 Jan 2021 -
Accepted
30 June 2021