OBJECTIVE: Infection and sepsis are major causes of morbidity and mortality after surgery of diabetic patients. Statins have been shown to exhibit anti-inflammatory and immunomodulatory (pleiotropic) effects, independent of lipid lowering. This study aimed to observe whether the pretreatment with simvastatin in a cecal ligation and perforation model of sepsis is beneficial in diabetic rats. METHODS: Fifty six Wistar rats were randomly assigned to non-diabetic group (n=28), and streptozotocin-induced diabetic group (n=28). Abdominal sepsis was induced in 14 diabetic and in 14 non diabetic rats and the other 28 rats were allocated on sham group. Sepsis rats and sham rats (each with 7 animals) were treated with oral simvastatin (20 mg kg-1 day-1) or normal saline solution 0.9%. Peripheral blood TNFα, IL-1β, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were tested in all the animals. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. RESULTS: Simvastatin reduced mortality in diabetic rats. Peripheral blood TNFα, IL-1β, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were lower in diabetic and non diabetics septic rats treated with simvastatin, than after saline treatment. CONCLUSION: Simvastatin showed anti-inflammatory effect, which could play some protection against the progress of sepsis in diabetic rats.
Simvastatin; Sepsis; Diabetes; Streptozotocin; Rats
