Soares et al.1414 Soares AF, Aquino AR, Carvalho CH, Nonaka CF, Almeida D, Pinto, LP. Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. Braz Dent J. 2011;22(4):312-6.
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Evaluate oral mucosa changes and qualitative microbiota changes in children with ALL under chemotherapy, as well as the use of 012% chlorhexidine in such patients. |
ALL |
17/2 to 12 years. |
Chlorhexidine mouthwash for 1 minute, twice a day (30 minutes after lunch and after last meal) for 10 days. |
Clinical exam of oral mucosa for detection of oral lesions and microbiological test. |
Presence of mucositis; effects of 0.12% chlorhexidine on oral microbiota. |
Costa et al.1515 Costa EM, Fernandes MZ, Quinder LB, de Souza LB, Pinto LP. Evaluation of an oral preventive protocol in children with acute lymphoblastic leukemia. Pesqui Odontol Bras. 2003;17(2):147-50.
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Check the effectiveness of a preventive oral protocol using 0.12% chlorhexidine mouthwashes in children with ALL submitted to anticancer treatment. |
ALL |
14/2 to 10 years. (7 test group /7 control group). |
The experimental group received supervised oral hygiene care and chlorhexidine mouthwash twice a day. The control group received supervised hygiene care with placebo mouthwash twice a day. The experiment started 1 day after and continued for up to 10 days after chemotherapy induction phase. |
Clinical oral mucosa exam. |
Evaluate the effect of chlorhexidine to treat oral manifestations; compare test and control groups. |
Choi & Kim1616 Choi SE, Kim HS. Sodium bicarbonate solution versus chlorhexidine mouthwash in oral care of acute leukemia patients undergoing induction chemotherapy: a randomized controlled trial. Asian Nurs Res. 2012;6(2):60-6.
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Compare the efficacy of sodium bicarbonate and c h l o r h e x i d i n e mouthwash to prevent oral manifestations in patients with ALL during chemotherapy induction phase |
ALL & AML |
48/ Mean of 38 years. (chlorhexidine group=24 patients; sodium b i c a r b o n a t e group = 24 patients). |
Os participantes de ambos os grupos foram orientados a realizar os bochechos 4 vezes ao dia, sendo iniciados 1 dia antes do início da quimioterapia ate o final da primeira fase do tratamento oncologico. |
Questionnaire, clinical oral mucosa exam and microbiological test. |
Presence of oral lesions; effect of mouthwashes on oral mucosa. |
Mehdipour et al.1717 Mehdipour M, Taghavi Zenoz A, Asvadi Kermani I, Hosseinpour A. A comparison between zinc sulfate and chlorhexidine gluconate mouthwashes in the prevention of chemotherapy-induced oral mucositis. Daru. 2011;19(1):71-3.
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Evaluate the efficacy of zinc oral antiseptic for chemotherapyinduced oral mucositis as compared to chlorhexidine mouthwash |
AML |
30 (15 Test/15 control) / age above 15 years. |
Induction and maintenance phase patients were evaluated. Patients of chlorhexidine and zinc sulfate groups were oriented to use mouthwash twice a day during 14 days. Patients were evaluated for 8 weeks. |
Clinical oral mucosa exam. |
Compare patients receiving 0.2% zinc sulfate to patients receiving 0.2% chlorhexidine gluconate to prevent oral mucositis |
Pereira Pinto et al.1313 Pereira Pinto L, de Souza LB, Gordón-Núñez MA, Soares RC, de Brito Costa EM, de Aquino AR, et al. Prevention of oral lesions in children with acute lymphoblastic leukemia. Int J Pediatr Otorhinolaryngol. 2006;70(11):1847-51.
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Evaluate clinical aspects of oral mucosa of children with ALL and determine the effect of 0.12% chlorhexidine to prevent oral complications in these patients. |
LLA |
33 Group I (23 children): Oral 0.12% chlorhexidine solution, 2X/ day, group II (10 children): not receiving solution. /2 to 15 years |
The experimental group had chlorhexidine mouthwashes for 1 minute, twice a day (30 minutes after lunch and after the last meal) during 10 days. Control group was not treated. |
Clinical oral cavity exam / digital palpation of oral mucosa and cytological swabs (obtained from oral mucosa in the beginning of chemotherapy intensification). |
Presence of mucositis; effects of 0.12% chlorhexidine; compare results among study groups. |
Setiawan, Reniarti & Oewen1818 Setiawan AS, Reniarti L, Oewen RR. Comparative effects of chlorhexidine gluconate and povidone iodine mouthwashes to chemotherapy induced oral mucositis in children with acute lymphoblastic leukemia. Int J of Oral Med Sci. 2006;5(1):1-5.
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Compare the effectiveness of chlorhexidine gluconate and povidoneiodine mouthwash for oral mucositis in children receiving chemotherapy for ALL. |
ALL |
18/ 2 to 10 years |
Children developing mucositis in the chemotherapy induction phase were evaluated. Group A received 0.12% chlorhexidine, group B povidone iodine, group C saliva solution. Mouthwashes were performed twice a day (morning and evening) being the protocol repeated every day until injury remission or for a maximum period of two weeks. |
Clinical oral mucosa exam. |
Evaluate the effects of chlorhexidine gluconate and povidone- iodine on oral mucosa and compare both to control group. |