BACKGROUND AND OBJECTIVES: Vanillosmopsis arborea Baker (Asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. Keeping in view the high content of α-bisabolol in Vanillosmopsis arborea (EOVA) bark essential oil, the aim of our study was to determine whether EOVA mitigates viscer METHOD: Mice (n = 8) were pretreated orally with EOVA (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (CPM 400 mg/kg), intracolonic mustard oil (MO 0.75%) or capsaicin (CAP 0.3%) were analyzed. RESULTS: Animals that received CFM, OM or CAP presented spontaneous nociceptive behaviors that were significantly suppressed by EOVA. CONCLUSION: These findings point to visceral antinociceptive properties of EOVA suggesting the potential use of Vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.
Essential oil; Vanillosmopsis arborea; Visceral pain
