Package of menthol measures for thirst relief: a randomized clinical study

To evaluate the effectiveness of the menthol package (lip hydration and ice popsicles) compared to a package of non-menthol measures (lip hydration and ice popsicles) as a way to relieve thirst in patients in the Anesthetic Recovery Room.

Method:

Randomized and parallel trial study, with 120 patients randomized patients in an experimental group - menthol measurements (n=59) and control group - measures without menthol (n = 61).

Results:

There was a significant (p<0.05) decrease in intensity, hydration, dryness and taste in the oral cavity between the three moments of assessment/intervention in the two groups. The difference was significant in the experimental group for thirst intensity at the second assessment/intervention point (p<0.05) after a single administration of the menthol package.

Conclusion:

There was a reduction in thirst intensity in both groups. Patients who received menthol packages showed a significant decrease in intensity after a single evaluation/intervention time. NCT: 02869139.

Descriptors:
Thirst; Menthol; Perioperative Nursing; Low temperature; Ice

Variable	Group		P value ^* * Mann-Whitney test.
Variable	Experimental mean (± SD)	Control mean (± SD)	P value ^* * Mann-Whitney test.
Age	37.4 (11.0)	39.5 (11.8)	0.34
Duration of anesthesia (hours)	3.2 (0.9)	3.0 (0.9)	0.07
Duration of the procedure (hours)	2.1 (0.7)	2.0 (0.8)	0.24
Duration of PAR (hours)	3.0 (0.6)	3.0 (0.8)	0.90
Duration of solids fasting (hours)	68.4 (4.0)	67.5 (4.4)	0.16
Duration of fluid fasting (hours)	18.4 (3.5)	18.0 (4.0)	0.55
Thirst intensity (M1)	7.6 (1.6)	7.4 (1.7)	0.38
Lip Hydration (M1)	3.7 (2.6)	3.7 (2.2)	0.71
Dryness of the oral cavity (M1)	7.8 (2.1)	7.0 (2.3)	0.06
Taste in the oral cavity (M1)	2.9 (2.1)	3.0 (2.2)	0.78

Groups / Moments	Attributes analyzed in the study
	Intensity		Hydration		Secura		Taste
	DF^* * DF = difference found	P value ^ Linear Regression with mixed effects.	DF^* * DF = difference found	P value ^ Linear Regression with mixed effects.	DF^* * DF = difference found	P value ^ Linear Regression with mixed effects.	DF^* * DF = difference found	P value ^ Linear Regression with mixed effects.
Experimental (M2 - M1)	3.5	<0.01	2.64	<0.01	3.48	<0.01	2.04	<0.01
Control (M2 - M1)	2.76	<0.01	2.59	<0.01	2.54	<0.01	1.58	<0.01
Experimental (M3 - M1)	4.85	<0.01	3.39	<0.01	4.67	<0.01	2.28	<0.01
Control (M3 - M1)	4.74	<0.01	3.45	<0.01	4.05	<0.01	2.1	<0.01
Experimental (M3 - M2)	1.35	<0.01	0.75	<0.01	1.19	<0.01	0.24	0.28
Control (M3 - M2)	1.98	<0.01	0.86	<0.01	1.51	<0.01	0.52	0.01
M1 (Experimental-Control)	0.22	0.38	0.12	0.71	0.70	0.06	0.08	0.78
M2 (Experimental-Control)	0.51	0.04	0.06	0.84	0.24	0.51	0.38	0.18
M3 (Experimental-Control)	0.12	0.65	0.17	0.58	0.08	0.82	0.1	0.71

Attributes	Moments of Evaluation			DF^* * DF = difference found	P value ^ Analysis of covariance (ANCOVA).
	Moment 1	Moment 2	Moment 3
	mean (± SD)	mean (± SD)	mean (± SD)
Thirst Intensity				0.32	0.32
Experimental	7.6 (1.6)	4.0 (1.9)	1.6 (1.9)
Control	7.4 (1.7)	4.54 (1.7)	1.7 (1.6)
Lip Hydration				0.00	0.99
Experimental	3.7 (2.6)	1.1 (1.5)	0.3 (1.3)
Control	3.7 (2.2)	1.1 (1.6)	0.2 (0.5)
Dryness of the oral cavity				0.78	0.05
Experimental	7.8 (2.1)	4.2 (2.4)	2.3 (2.4)
Control	7.0 (2.3)	4.4 (2.2)	2.3 (2.0)
Taste in the oral cavity				0.36	0.28
Experimental	2.9 (2.1)	0.9 (1.3)	0.5 (0.8)
Control	3.0 (2.2)	1.4 (1.5)	0.8 (1.1)

Attributes Distribution of satiety reach in M3
Thirst intensity in M3
Group	Reach of satiety		OR^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
	Yes	No	OR^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
Experimental	31 (52.5%)	28 (47.5%)	1.71	0.83	3.52	0.15
Control	24 (39.3%)	37 (60.7%)	1	-		0.15
Lip Hydration in M3
Group	Reach of satiety		OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
	Yes	No	OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
Experimental	52 (88.1%)	7 (11.9%)	1.29	0.44	3.71	0.64
Control	52 (85.2%)	9 (14.8%)	1	-		0.64
Dryness of the oral cavity in M3
Group	Reach of satiety		OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
	Yes	No	OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
Experimental	22 (39.3%)	37 (62.7%)	1.67	0.77	3.64	0.19
Control	16 (26.2%)	45 (73.8%)	1	-		0.19
Taste in the oral cavity in M3
Group	Reach of satiety		OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
	Yes	No	OR ^* * OR: OddsRatio	RI (95%)^ IC: Intervalo de Confiança		P value^* ***** Regressão Logística Simples.
Experimental	38 (64.4%)	21 (35.6%)	1.34	0.64	2.81	0.43
Control	35 (57.4%)	26 (42.6%)	1	-		0.43

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[1] Corresponding Author: Ligia Fahl Fonseca. E-mail: ligiafahl@gmail.com