Mobile applications in surgical patient health education: an integrative review

Aplicaciones de celular en la educación en salud del paciente quirúrgico: una revisión integrative

Abstract

OBJECTIVE

To analyze the scientific literature produced on health education through mobile applications for surgical patients.

METHOD

An integrative literature review performed through consultation in the following portals and/or databases: VHL; PubMed; Web of Science; Scopus; LILACS and CINAHL. The search was guided by the question: “What is the evidence on the use of mobile applications in the health education of surgical patients?” conducted from July to September 2017, including articles published from the year 2000 to 2017.

RESULTS

Five articles published in international journals in English with varied methodological designs were selected. Among the studies found, 60% used an educational intervention through smartphone applications in the pre and postoperative periods, and 40% of the studies had an evidence level of 2B.

CONCLUSION

The studies showed that the use of smartphone applications in educating and guiding surgical patients was effective. However, there is still a gap in studies which demonstrate surgical patient education through smartphone applications.

Descriptors:
Perioperative Care; Health Education; Mobile Applications; Smartphone; Perioperative Nursing; Review

Resumen

OBJETIVO

Analizar la literatura científica producida acerca de la educación en salud por medio de aplicaciones de teléfono celular para pacientes quirúrgicos.

MÉTODO

Revisión integrativa de la literatura, realizada mediante consulta en las páginas web y/o bases de datos: BVS; PubMed; Web of Science; Scopus; LILACS y CINAHL. La búsqueda fue orientada por la pregunta: “¿Cuáles son las evidencias del empleo de aplicaciones de teléfonos celulares en la educación en salud de pacientes quirúrgicos?" y llevada a cabo en el período de julio a septiembre de 2017, incluyéndose artículos publicados desde el año 2000 hasta el 2017.

RESULTADOS

Fueron seleccionados cinco artículos publicados en periódicos internacionales en inglés, con diseños metodológicos variados. Entre los estudios encontrados, el 60% utilizaron la intervención educativa mediante aplicaciones de smartphone en los períodos pre y posoperatorio. Se observó que el 40% de los estudios presentaron nivel de evidencia 2B.

CONCLUSIÓN

Los estudios mostraron que el empleo de aplicaciones de smartphone en la educación y orientación del paciente quirúrgico fue efectivo. Aun así existe una laguna de estudios que evidencien la práctica de educación del paciente quirúrgico mediante aplicaciones de smartphone.

Descriptores:
Atención Perioperativa; Educación en Salud; Aplicaciones Móviles; Teléfono Inteligente; Enfermería Perioperatoria; Revisión

Resumo

OBJETIVO

Analisar a literatura científica produzida sobre educação em saúde por meio de aplicativos de celular para pacientes cirúrgicos.

MÉTODO

Revisão integrativa da literatura, realizada por meio de consulta nos portais e/ou bases de dados: BVS; PubMed; Web of Science; Scopus; LILACS e CINAHL. A busca foi norteada pela pergunta: “Quais as evidências do uso de aplicativos em celulares na educação em saúde de pacientes cirúrgicos?” e realizada no período de julho a setembro de 2017, incluindo artigos publicados a partir do ano de 2000 até 2017.

RESULTADOS

Foram selecionados cinco artigos publicados em periódicos internacionais em inglês, com desenhos metodológicos variados. Entre os estudos encontrados, 60% utilizaram a intervenção educativa por meio de aplicativos de smartphone nos períodos pré e pós-operatório. Observou-se que 40% dos estudos tiveram nível de evidência 2B.

CONCLUSÃO

Os estudos mostraram que o uso de aplicativos de smartphone na educação e orientação do paciente cirúrgico foi efetivo. Ainda assim, há uma lacuna de estudos que evidenciem a prática de educação do paciente cirúrgico por meio de aplicativos de smartphone.

Descritores:
Assistência Perioperatória; Educação em Saúde; Aplicativos Móveis; Smartphone; Enfermagem Perioperatória; Revisão

Introduction

Health education has dimensions which encompass several areas of daily life and it directs the individual, the community and society to perform self-care when contemplating the political, collective, religious and cultural areas. Disseminating health education means transmitting information, requiring a theoretical-scientific basis of its issuer which must have all the possible resources to achieve its goal of stimulating, raising awareness and mobilizing the recipient of information to confront situations which may compromise their welfare¹.

Promoting health education becomes a continuous process of inquiry, reflection and questioning by the professionals who implement this practice, especially nurses who work in the various spheres of health services. The knowledge transferred by these professionals aims to assist self-care actions and stimulate the prevention of diseases and health problems through such actions. Education is present in personal contact, regardless of the environment, and can be aided by mechanisms that facilitate its comprehension through printed materials, educational technologies and the Internet, which is currently the most widespread means of communication^1-2.

In the context of the surgical patient, guidance can be performed through educational actions with accessible language, aiding in clarifying questions and providing education regarding the perioperative period. The perioperative period is understood as the time span which comprises the following steps: immediate preoperative; trans-operative; intraoperative; anesthetic recovery and immediate postoperative^2-3.

The use of leaflets, explanatory brochures and even oral guidance are the most widespread means in educational action. But with technological advancement, one now sees the use of other educational tools such as mobile/tablet applications which have proven to be a trend between professionals and patients, evidencing adherence to educational models via smartphones⁴.

Based on this scenario, this study aims to analyze the scientific literature produced on health education through mobile smartphone applications for surgical patients.

METHOD

Study design

The methodology employed in this study is an “Integrative Literature Review, a research method which uses evidence-based practice, synthesizes available research on a given subject, and enables practice to be guided by scientific knowledge”⁵.

The following predictive steps of an integrative review were implemented in order to perform this study: “identify the theme and elaborate the guiding question, conduct a search in the literature using inclusion and exclusion criteria, define the information to be extracted from the selected studies through a previously constructed bibliographic form, data collection, perform an evaluation implementing a critical analysis of the studies included in the review, discuss the results and present the integrative review”⁵.

Data collection

The search was guided by the question “What is the evidence on the use of mobile applications in the health education of surgical patients?” carried out from July to September 2017, including articles published from 2000 to 2017. The following databases and/or portals were used to select the articles: Biblioteca Virtual em Saúde (BVS); National Library of Medicine (PubMed); Web of Science; Scopus; Literatura Latino-Americana e do Caribe em Ciência da Saúde (LILACS) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL).

Inclusion criteria were: articles published in Portuguese, English and Spanish that reported the use of mobile applications for health education, available in full text formats. Exclusion criteria were: studies with other educational technologies such as brochures, video or oral communications, and those which did not respond to the objective of this review.

The following Descriptors in Health Sciences (DECS) and Medical Subject Headings (MESH) were used for the search: “Education materials”, “Health education”, “Patient education”, “Smartphone” or “Smart Phone”, “Surgery”, “Cell Phone”, “Mobile Phone”, “Surgical patients”, “Mobile Applications” and the term “Education intervention”. Controlled descriptors are considered to be standardized terms, defined by experts. Therefore, the selected descriptors from the indexed vocabulary represented the focal point of the work.

Strategies were combined in different ways in order to achieve a broad search due to the access characteristics of the selected databases, “having the study question and the previously established inclusion criteria as a guiding axis” (Chart 1)⁶.

Chart 1
Search strategies according to database/portal.

Database	Search structure
BVS	Patient education AND smartphone Education intervention AND mobile phone AND surgical patients (“Smartphone” OR “Mobile Phone”) AND (Orientation OR Advice) AND (“Pacientes Cirúrgicos” OR “Paciente Cirúrgico” OR “Surgical Patients” OR “Surgical Patient”)
PubMed	((“Mobile Applications”[Mesh] OR “Mobile Applications”[tiab])) AND surgery
Scopus	(Smartphone OR “Mobile Phone” OR “Cell Phone” OR Cellphone OR “Smart Phone”) AND (Patient* AND Surgery)
Web of Science	(Smartphone OR “Mobile Phone” OR “Cell Phone” OR Cellphone OR “Smart Phone”) AND (Patient* AND Surgery)
LILACS	(Smartphone OR “Mobile Phone” OR “Cell Phone” OR Cellphone OR “Smart Phone”) AND (Patient* AND Surgery)
CINAHL	(Smartphone OR “Mobile Phone” OR “Cell Phone” OR Cellphone OR “Smart Phone”) AND (Patient* AND Surgery)
Medline	(Smartphone OR “Mobile Phone” OR “Cell Phone” OR Cellphone OR “Smart Phone”) AND (Patient* AND Surgery)

Data analysis

Studies published in the national and international scientific literature were analyzed by title and abstract. Data were collected and analyzed using an instrument adapted from the instrument created in a positioning injury study⁶. Therefore, the authors employed the following: identify the original article and methodological characteristics of the study, evaluate the methodological rigor, the interventions measured and the results found. The instrument was adapted to the object of the present investigation, containing the following items: article title, journal title, authors, country, language, publication year, study type, research objective or question, study population, study period, intervention, evaluation method, measuring instrument, statistical analysis, outcome and conclusion.

We used the Oxford level of evidence⁷ for the methodological evaluation of the selected studies, in which the study evidence is classified into recommendation grades of 1a, 1b, 1c, 2a, 2b, 2c, 3a, 3b, 4 and 5, as well as in the following domains: therapy, prevention, etiology and harm; prognosis; diagnosis; prevalence studies and differential diagnosis; economic and decision. Thus, the studies were categorized according to the degree of recommendation and the respective domain described on the scale, characterizing each study according to the employed method. A synoptic table was then prepared to present the synthesis of the articles containing the following characteristics: study code, sample, objective, intervention, measuring instrument, result and level of evidence.

The search in the selected databases resulted in 1,374 articles, from which 55 were excluded because they were duplicates, remaining 1,319 articles; 1,293 articles were removed after reading the titles and abstracts because they did not meet the inclusion criteria, leaving 26 articles. From these, 21 articles were fully evaluated and excluded because they did not answer the guiding question of this review. Thus, five articles were selected that met the inclusion criteria at the end of this analysis process and constituted the final sample. Figure 1 describes the article selection and inclusion process.

Figure 1:
Selection process and inclusion of the articles.

RESULTS

The articles included in this review were published in the English language between 2015 and 2017, highlighting the years 2016 and 2017, both with 40% of publications. The studies were published in the journals: Obes Surg⁸, Comput Inform Nurs⁹, Breast¹⁰, JMIR Mhealth UHealth¹¹ and Surg Technol Int¹².

Regarding the location and origin of the studies, three (60%) were conducted in the United States^8,11-12, one (20%) in Ireland¹⁰ and one (20%) in South Korea¹⁰. The research designs of the included studies were: a randomized clinical trial¹⁰; a quasi-experimental pre- and post-test study⁹; a follow-up pilot study¹²; and a prospective cohort^8,11.

Regarding the level of evidence according to the Oxford classification⁷, two studies presented an evidence recommendation of A, with studies at level 1B¹⁰ and 1C⁹, and three studies with recommendation B, with studies at level 2B^8,11 and 2C¹².

The participants included in the studies had homogeneous sociodemographic characteristics regarding age, education and gender, except one study¹⁰ composed only of women. The sample size of the studies ranged from 17 to 123 participants, aged over 18 years. The sample size calculation was performed in four (80%) studies^8-11. General surgery⁹, bariatric⁸, urological⁹, neurological⁹, orthopedic^9,12, breast cancer¹⁰ and coloproct¹¹⁾ surgery patients were addressed.

Chart 2 presents a synthesis of the studies included in the review containing the author(s), sample, objective, intervention, measuring instrument, result and level of evidence.

Chart 2
Summary of studies included in the review.

Author	N	Objective	Intervention	Measuring instrument	Result	Evidence level
Mundi et al.(8)	30	Evaluate the acceptability and effectiveness of a mobile app in preparing patients for bariatric surgery.	Mobile application with videos and messages, preoperatively. Application of the knowledge test before the intervention and after 12 weeks. Physical activity and usability test applied after 12 weeks.	Knowledge Test International Physical Activity Short Form Questionnaire (IPAQ-SF)/Instrument developed by the researcher regarding usability.	Only 10 patients completed the study. There was an increase in nutritional knowledge, and greater engagement in a healthy lifestyle. Application adapted to the patient’s daily routine, was useful for surgery preparation, patients reported better connection with the surgical team.	2B
Cho, Lee(9)	123	To evaluate the knowledge acquired using the Safe patients mobile app in patients undergoing general, urological, orthopedic and neurological surgery.	Application usage for 3 days. Evaluation moment: before and after 3 days.	Instrument developed by the researcher with seven true and false questions about patient safety.	Average correct answers pre-test of 64.8% and post-test of 75.8% (p<0.001).	1C
Foley et al.(10)	39 IG=13 CG=26	Evaluate the effectiveness of using an iPad app to reduce anxiety and depression in patients undergoing mastectomy.	IPad app with information, animations and comfort messages. Time of assessment: one week before surgery, when they received iPad, and postoperatively after one week, in routine outpatient consultations.	Hospital Anxiety and Depression Scale (HADS)/ Mini-Mental Adjustment to Cancer (Mini-MAC)/ The Information Technology Familiarity Questionnaire/ Information Satisfaction Questionnaire.	Homogeneous groups in the preoperative HADS scale score and immediate postoperative, but significantly lower in the control group patients in the 7th postoperative period (p = 0.029 for anxiety and 0.022 for depression). There was no significant difference in 4 of the 5 domains of the Mini-MAC questionnaire. Satisfaction with the information received by the application was similar between the pre and postoperative groups.	1B
Scott et al.(11)	20	To evaluate the interest in using self-reporting mobile applications and warning sign screening in patients after colorectal surgery and to better understand the factors that affect postoperative use of the application at home.	Application presented to the patient upon admission and instructed to use daily for 2 weeks after hospital discharge. (There was a $10 incentive to use).	System Usability Scale (SUS)/Semi-structured interview.	Loss of five patients. SUS scale score of 95. Interview results: 75% daily use; frequency of use: 80% at least seven times and 26.7% over 25 times. Overall impression: The app serves as a second opinion or supplement to the information received previously.	2B
Kim et al.(12)	17	To evaluate the effectiveness of the mobile application with the iGetBetter (iGB) program as an alternative to support and encourage patients for better adherence to the preoperative and postoperative total knee arthroplasty (TKA) protocol.	Provided an iPad mini to the patients with internet to access the app. Patients used the app in self-preparation and perioperative recovery, with manual data recording on the iPad mini. Data to be recorded: execution of the care plan during the day; response to common reminders in pre- and postoperative TKA protocols received by the application.	IGB Clinical Dashboard, the system triggers alerts to the clinician if patients provide answers out of range of what the clinician considers acceptable.	In the 14 days before the operation, 92.3% of the patients participated in the education accesses (n=6), a necessary amount, with an average of 3.5 and a 59% reduction in adherence. Postoperatively there was an average of 17.8 accesses in 30 days (59.2%), with no significant difference between the number of accesses in the preoperative phase. 2,045 responses (157 answers per patient) were given to 3,984 specific instructions considering patient losses (307 questions per patient), involving consultations and follow-up, which resulted in a 51% response rate.	2C

Three (60%) studies applied the intervention in the preoperative and postoperative periods^8,10,12, while two (40%) others employed the postoperative intervention^9,11. These interventions were performed through the contents contained in the applications such as videos, messages, reminders and animations which used information from educational protocols in the pre and post-operative periods.

Four (80%) studies used mobile apps developed in the English language^8,10-12, and one application was produced in the Korean language⁹.

The studies included in this review have named the apps and made them available in their free version. Two (20%) used applications available on the Apple (iOS) and Google (Play Store) platforms^8,11 with their respective names “Smartphone app” and “mHealth”; one named the app “GraphPad”¹⁰ and another named “iGetBetter”¹², and both used the Apple (iOS) platform. The “Safe Patients” app⁹ did not cite an available platform.

Regarding application components, studies generally focused interventions through messages, images, animations, information on surgical techniques, treatments, questionnaires, and even games. These interventions were used to promote surgical patient health education, so that each study structured its application to the observed sample with the intention of employing surgical orientation in the perioperative period, as presented above in the study summary chart.

The mobile applications used for educating and orientating the surgical patient were effective in 60% of the publications, the employed interventions improved the patients’ knowledge about the procedure and care in the pre- and post-operative periods.

DISCUSSION

Few studies answered the guiding question. Recent publications connote a new area of research which is little explored by health professionals.

Although the studies had a small sample size and the results cannot be generalized, the studies show positive results regarding the acquired knowledge^8-9, user satisfaction^10-11 and the adherence rate to the guidelines¹².

One study¹³ on patient evaluation of mobile apps found that the most commonly used health apps covered the topics of exercise, diet and puzzles. Although participants more often shared information about health applications on their social networks, information was shared less frequently with providers, and medical recommendation played a small role in influencing patient use of health applications¹³.

However, a review on the use of other technologies, such as patient education leaflets, concluded that whatever the clinical situation, leaflets improve patient knowledge and satisfaction. Short-term leaflets improve treatment adherence for acute conditions, while their impact on adherence varies depending on the context, how the leaflets are administered and the invasiveness of the intervention for chronic diseases, invasive procedures or screening situations¹⁴.

Tablets and mobile phones are becoming increasingly popular with users nowadays. The number of applications has increased significantly, including applications used as methods to meet health needs. These applications are becoming viable and useful tools for the care of surgical patients, enabling their communication with health professionals regarding the transmission of information and care guidance¹⁵.

One study⁹ which used games and safety questions in the application showed a significantly higher percentage of correct patient answers when comparing the two pre- and post-intervention moments. The study emphasized the importance of nurses’ approval and participation in application development⁹.

Another study¹⁰ reported advantages in mobile applications compared to traditional methods of information dissemination, such as brochures and websites. Among these advantages is the amount of individuals who can be reached and benefited with the information contained in these mobile tools, anywhere in the world.

Mobile devices are globally interconnecting people everywhere, no matter where they are. This interconnection enables an unprecedented ability to improve health communication. An example of this improvement is smartphone apps to monitor and diagnose diseases, as well as to bring patients and healthcare professionals even closer¹⁶.

It is estimated that approximately over 500 million people have their own smartphone, meaning that mobile tools are expanding among professionals and patients for health education and disease monitoring¹⁷.

One limitation found in this integrative review was the absence of research with robust designs, considering that the best evidence is obtained through studies with high methodological quality.

CONCLUSION

Studies on the use of patient education applications are recent. Publications from the last 2 years show that the use of messages, videos, images and animations are the resources inserted in applications for smartphones or tablets which are being used in educating surgical patients. The studies confirm that such tools present effective intervention results regarding perioperative knowledge and care.

It is important to discuss the theme and the applicability of these tools in health education and self-care of surgical patients more frequently. The need for further research in the nursing area using new communication technologies is also emphasized.

References

• ¹
  Guilbert TW, Bacharier LB, Fitzpatrick AM. Severe asthma in children. J Allergy Clin Immunol Pract. 2014;2(5):489-500. DOI: https://doi.org/10.1016/j.jaip.2014.06.022.
  » https://doi.org/10.1016/j.jaip.2014.06.022
• ²
  Groot EP, Kreggemeijer WJ, Brand PL. Getting the basics right resolves most cases of uncontrolled and problematic asthma. Acta Paediatr. 2015;104(9):916-21. DOI: https://doi.org/10.1111/apa.13059.
  » https://doi.org/10.1111/apa.13059
• ³
  Sanchis J, Gich I, Pedersen S; Aerosol Drug Management Improvement Team (ADMIT). Systematic review of errors in inhaler use: has patient technique improved over time? Chest. 2016 Aug;150(2):394-406. DOI: https://doi.org/10.1016/j.chest.2016.03.041.
  » https://doi.org/10.1016/j.chest.2016.03.041
• ⁴
  Bracken M, Fleming L, Hall P, Van Stiphout N, Bossley C, Biggart E, et al. The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child. 2009;94(10):780-4. DOI: 10.1136/adc.2008.152140.
  » https://doi.org/10.1136/adc.2008.152140
• ⁵
  Hughes DM, McLeod M, Garner B, Goldbloom RB. Controlled trial of a home and ambulatory program for asthmatic children. Pediatrics. 1991;87(1):54-61.
• ⁶
  Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-73. DOI: https://doi.org/10.1183/09031936.00202013.
  » https://doi.org/10.1183/09031936.00202013
• ⁷
  Liu AH, Zeiger R, Sorkness C, Mahr T, Ostrom N, Burgess S, et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol. 2007;119(4):817-25. DOI: https://doi.org/10.1016/j.jaci.2006.12.662.
  » https://doi.org/10.1016/j.jaci.2006.12.662
• ⁸
  Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59-65. DOI: https://doi.org/10.1016/j.jaci.2003.09.008.
  » https://doi.org/10.1016/j.jaci.2003.09.008
• ⁹
  Lasmar L, Camargos P, Champs NS, Fonseca MT, Fontes MJ, Ibiapina C, et al. Adherence rate to inhaled corticosteroids and their impact on asthma control. Allergy. 2009;64(5):784-9. DOI: https://doi.org/10.1111/j.1398-9995.2008.01877.x.
  » https://doi.org/10.1111/j.1398-9995.2008.01877.x
• ¹⁰
  Alexander DS, Geryk L, Arrindell C, DeWalt DA, Weaver MA, Sleath B, et al. Are children with asthma overconfident that they are using their inhalers correctly? J Asthma. 2016;53(1):107-12. DOI: https://doi.org/10.3109/02770903.2015.1057848.
  » https://doi.org/10.3109/02770903.2015.1057848
• ¹¹
  Walia M, Paul L, Satyavani A, Lodha R, Kalaivani M, Kabra SK. Assessment of inhalation technique and determinants of incorrect performance among children with asthma. Pediatr Pulmonol. 2006;41(11):1082-7. DOI: https://doi.org/10.1002/ppul.20498.
  » https://doi.org/10.1002/ppul.20498
• ¹²
  Kamps AW, Brand PL, Roorda RJ. Determinants of correct inhalation technique in children attending a hospital-based asthma clinic. Acta Paediatr. 2002;91(2):159-63.
• ¹³
  Burkhart PV, Rayens MK, Bowman RK. An evaluation of children's metered-dose inhaler technique for asthma medications. Nurs Clin North Am. 2005;40(1):167-82. DOI: https://doi.org/10.1016/j.cnur.2004.08.010.
  » https://doi.org/10.1016/j.cnur.2004.08.010
• ¹⁴
  Normansell R, Kew KM, Mathioudakis AG. Interventions to improve inhaler technique for people with asthma. Cochrane Database Syst Rev. 2017;13(3):CD012286. DOI: https://doi.org//10.1002/14651858.CD012286.pub2.
  » https://doi.org/10.1002/14651858.CD012286.pub2
• ¹⁵
  Zambelli-Simões L, Martins MC, Possari JCC, Carvalho GB, Coelho ACC, Cipriano SL, et al. Validation of scores of use of inhalation devices: valoration of errors. J Bras Pneumol. 2015;41(4):312-22. DOI: http://dx.doi.org/10.1590/S1806-37132015000004435.
  » https://doi.org/10.1590/S1806-37132015000004435
• ¹⁶
  Bynum A, Hopkins D, Thomas A, Copeland N, Irwin C. The effect of telepharmacy counseling on metered-dose inhaler technique among adolescents with asthma in rural Arkansas. Telemed J E Health. 2001;7(3):207-17.
• ¹⁷
  Price D, Bosnic-Anticevich S, Briggs A, Chrystyn H, Rand C, Scheuch G, et al. The Inhaler Error Steering Committee: inhaler competence in asthma: common errors, barriers to use and recommended solutions. Respir Med. 2013;107(1):37-46. DOI: https://doi.org/10.1016/j.rmed.2012.09.017.
  » https://doi.org/10.1016/j.rmed.2012.09.017
• ¹⁸
  Rottier BL, Rubin BK. Asthma medication delivery: mists and myths. Paediatr Respir Rev. 2013;14(2):112-8. DOI: https://doi.org/10.1016/j.prrv.2013.02.013.
  » https://doi.org/10.1016/j.prrv.2013.02.013
• ¹⁹
  Klok T, Kaptein AA, Duiverman EJ, Brand PL. It's the adherence, stupid (that determines asthma control in preschool children)! Eur Respir J. 2014;43(3):783-91. DOI: https://doi.org/10.1183/09031936.00054613.
  » https://doi.org/10.1183/09031936.00054613

Publication Dates

• Publication in this collection
  30 Mar 2020
• Date of issue
  2020

History

• Received
  09 Apr 2018
• Accepted
  18 July 2019