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Artigo Original • Rev. esc. enferm. USP 49 (01) • Jan-Feb 2015 • https://doi.org/10.1590/S0080-623420150000100009   copy

Pharmacotherapy and analysis of gaseous mediators in hypertensive patients* * Extracted from the thesis "Farmacoterapia e análise de mediadores gasosos em pacientes hipertensos"' School of Nursing of Ribeirão Preto, University of São Paulo, 2014

Farmacoterapia y análisis de mediadores gaseosos en pacientes hipertensos

Authorship SCIMAGO INSTITUTIONS RANKINGS

OBJECTIVE

To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension.

METHODS

Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists.

RESULTS

It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0.03) and the hydrogen sulphide concentration was significantly higher in hypertensive plasma in use of calcium channel antagonists (p<0.002).

CONCLUSION

The findings suggest that these medications have as additional action mechanism the improvement of endothelial dysfunction by elevate plasma levels of vasodilatory substances.

Hypertension; Nitric Oxide; Hydrogen Sulfide; Antihypertensive Agents

Universidade de São Paulo, Escola de Enfermagem Av. Dr. Enéas de Carvalho Aguiar, 419 , 05403-000 São Paulo - SP/ Brasil, Tel./Fax: (55 11) 3061-7553, - São Paulo - SP - Brazil
E-mail: reeusp@usp.br
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