Gene-Xpert Ultra for the diagnosis of extrapulmonary tuberculosis in children and adolescents

Aurilio, Rafaela Baroni; Ferreira, Sidnei; Parente, Ana Alice Amaral Ibiapina; Sant’Anna, Maria de Fátima Pombo; Pereira, Cláudia Stella; Malaquias, Thiago da Silva Santos; Kritski, Afrânio Lineu; Sant’Anna, Clemax Couto

doi:10.1590/S1678-9946202264012

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Revista do Instituto de Medicina Tropical de São Paulo

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BRIEF COMMUNICATION • Rev. Inst. Med. trop. S. Paulo 64 • 2022 • https://doi.org/10.1590/S1678-9946202264012 copy

Gene-Xpert Ultra for the diagnosis of extrapulmonary tuberculosis in children and adolescents

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

This prospective study describes the use of Gene-Xpert Ultra for the diagnosis of extrapulmonary tuberculosis (EPTB) in children and adolescents, in Rio de Janeiro, Brazil. Eighteen patients were studied; the final diagnosis of EPTB was established in 13 (72%). Gene-Xpert Ultra results showed detection in 10/13 (77%) of EPTB cases (7 of these 10 with trace-positive results). Gene-Xpert Ultra proved to be a promising method for the diagnosis of childhood EPTB.

Extrapulmonary tuberculosis; Children; Adolescents; Diagnoses; Real-time PCR

Patient number	Age (years)	Close contact with TB	TST	Sample	Ultra result	RMP-resistance	AFB	Culture	Final diagnoses
1	0.9	Yes	Positive	Lymph node	Not detected	No	Negative	Negative	Peripheral lymph node TB
2	1.5	No	Not performed	Lymph node	Detected	No	Negative	Positive^a	Peripheral lymph node TB
3	2	No	Positive	Soft tissue swelling over the sternum	Detected	No	Negative	Positive^a	Bone TB + Pulmonary TB
4	2.1	Yes	Positive	Lymph node	Trace-positive	Indeterminate	Negative	Negative	Peripheral lymph node TB
5	6.5	No	Negative	Lymph node	Trace-positive	Indeterminate	Negative	Negative	Peripheral lymph node TB
6	8.5	No	Negative	Pleural effusion	Trace-positive	Indeterminate	Negative	Negative	Pleural TB
7	8.9	No	Positive	Lymph node	Detected	No	Negative	Positive^a	Peripheral lymph node TB
8	10	WI	Negative	Peritoneal fluid	Trace-positive	No	Negative	Negative	Peritoneal TB
9	10.5	No	Negative	Bone	Trace-positive	Indeterminate	Negative	Negative	Osteoarticular TB
10	10.9	No	Positive	Pleural effusion	Trace-positive	Indeterminate	Negative	Negative	Pleural TB
11	11.2	No	Negative	Sacroiliac abscess	Trace-positive	Indeterminate	Negative	Negative	Osteoarticular TB + Pulmonary TB
12	11.3	No	Positive	Lymph node	Not detected	No	Negative	Negative	Peripheral lymph node TB^b
13	11.5	Yes	Positive	Pleura	Not detected	No	Negative	Negative	Pleural TB^c

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E-mail: revimtsp@usp.br

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[1] Correspondence to: Rafaela Baroni Aurilio Universidade Federal do Rio de Janeiro, Instituto de Pediatria e Puericultura Martagão Gesteira, R. Bruno Lobo 50, CEP 21941-912, Rio de Janeiro, RJ, Brazil Tel: +55 21 3938-4811 E-mail:rafabaroni@yahoo.com.br