A co-infecção por dengue vírus pode ocorrer em áreas com circulação endêmica, nas quais diferentes sorotipos vêm circulando durante muitos anos. Neste trabalho relatamos um caso de co-infecção por DENV-1/DENV-4 em soro humano, detectado por testes moleculares. Análises filogenéticas das sequências obtidas indicaram a presença do genótipo V e II de DENV-1 e DENV-4, respectivamente.
| Serotype and Genotype | Genbank Accession | Isolation site | Strains | Isolation Year |
|---|---|---|---|---|
| Serotype 1 | ||||
| D1G1 | AB074760.1 | Japan | Mochizuki | 2001 |
| D1G1 | AF180817.1 | USA | 16007 | 1999 |
| D1G1 | JN054255.1 | Sri Lanka | DV1_SL_2010b | 2010 |
| D1G1 | GQ398255.1 | Singapore | SG/07K3640DK1/2008 | 2008 |
| D1G1 | DQ193572.1 | Fujian/China | Fj231/04 | 2004 |
| D1G2 | FJ196841.1 | Guangzhou/China | GD54/03 | 2003 |
| D1G2 | FJ196842.1 | Guangzhou/China | GD66/03 | 2003 |
| D1G2 | EF440432.1 | Australia | ET243 | 2000 |
| D1G2 | EF025110.1 | China | 71/02GZ | 2006 |
| D1G3 | AB074761.1 | Japan | A88 | 2002 |
| D1G3 | DQ285561.1 | Seychelles/ France | 1480/04 | 2004 |
| D1G4 | U88535.1 | Nauru Island | Clone WestPac | 1997 |
| D1G4 | M23027.1 | Nauru Island | Nauru Island | 1994 |
| D1G5 | FJ850087.1 | Northern Brazil | BR/BID-V2395/2006 | 2006 |
| D1G5 | AF226685.2 | Rio de Janeiro/Brazil | Den1BR/90 | 2000 |
| D1G5 | AF513110.1 | Curitiba/Brazil | BR/01-MR | 2002 |
| D1G5 | FJ850075.1 | Northern Brazil | BR/BID-V2381/2002 | 2002 |
| D1G5 | FJ850090.1 | Northern Brazil | BR/BID-V2398/2007 | 2007 |
| D1G5 | FJ850084.1 | Northern Brazil | BR/BID-V2392/2005 | 2005 |
| D1G5 | JX502769.1 | Brazil | RR_DENV1_09007 | 2009 |
| D1G5 | FJ850070.1 | Northern Brazil | BR/BID-V2374/2000 | 2000 |
| D1G5 | FJ850071.1 | Northern Brazil | BR/BID-V2375/2000 | 2000 |
| D1G5 | AB519681.1 | Brasilia/Brazil | SB 01057805 (DF02) | 2002 |
| D1G5 | FJ850081.1 | Northern Brazil | BR/BID-V2389/2004 | 2004 |
| D1G5 | HM043709.1 | Brazil | 55/2009ES | 2009 |
| D1G5 | JN086990.1 | Brazil | A | 2010 |
| D1G5 | JN086991.1 | Brazil | B | 2010 |
| Serotype 4 | ||||
| D4G1 | FJ196850.1 | Guangzhou/China | GD09/1990 | 1990 |
| D4G1 | AF289029.1 | Guangzhou/China | Guangzhou B5 | 2000 |
| D4G1 | AF177542.1 | Mindanao/Philippines | Mindanao/BDJ/1995 | 1995 |
| D4G1 | GQ868594.1 | Philippines | PH/BID-V3361/1956/1956 | 1956 |
| D4G2 | EU854295.1 | Puerto Rico | US/BID-V1083/1986 | 1986 |
| D4G2 | GQ868582.1 | Santander/Colombia | CO/BID-V3409/2001 | 2001 |
| D4G2 | AH011968.1 | Costa Rica | D4.108_1996CR | 1996 |
| D4G2 | JN559741.2 | Boa Vista/Brazil | ROR7365 | 2010 |
| D4G2 | JN983813.1 | Boa Vista/Brazil | Br246RR/2010 | 2010 |
| D4G2 | HQ822126.1 | Roraima/Brazil | Br347RR | 2010 |
| D4G2 | HQ822125.1 | Roraima/Brazil | Br272RR | 2010 |
| D4G2 | JN092557.1 | Brazil | SPH318527 | 2011 |
| D4G2 | JN712226.1 | São José do Rio Preto/Brazil | RP/BR/2011/131 | 2011 |
| D4G2 | JN712225.1 | São José do Rio Preto/Brazil | SJRP/BR/2011/167 | 2011 |
| D4G2 | JQ513335.1 | Belém/Brazil | BeH778494 | 2011 |
| D4G2 | JN092556.1 | Brazil | SPH319325 | 2011 |
| D4G2 | JN092555.1 | Brazil | SPH319268 | 2011 |
| D4G2 | JN092556.1 | Brazil | SPH319325 | 2011 |
| D4G2 | JQ513333.1 | Boa Vista/ Brazil | ROR7542 | 2010 |
| D4G2 | JQ513340.1 | Boa Vista/ Brazil | ROR7591 | 2010 |
| D4G2 | AY152252.1 | San Juan/ Puerto Rico | D4.69_1987 | 1987 |
| D4G2 | AY152084.1 | San Juan/ Puerto Rico | D4.84_1994 | 1994 |
| D4G2 | AY152056.1 | San Juan/ Puerto Rico | D4.17_1998 | 1998 |
| D4G2 | AY152196.1 | San Juan/ Puerto Rico | D4.28_1992 | 1992 |
| D4G2 | AY152336.1 | San Juan/ Puerto Rico | D4M.5_1982 | 1982 |
| D4G2 | AY152360.1 | Dominica | D4M.44_1981DM | 1981 |
| D4G3 | HQ875339.1 | Singapura | SG(EHI)D4/2641Y08 | 2008 |
| D4G3 | GQ398256.1 | Singapura | SG/06K2270DK1/2005 | 2005 |
| D4G3 | AY618993.1 | Bangkok /Thailand | ThD4_0734_00 | 2000 |
| Serotypes 1 to 4 using as outgroups | ||||
| DENV-1 | AB074760.1 | Japan | 2001 | |
| DENV-3 | AF317645.1 | Guangxi/China | 2000 | |
| DENV-2 | HM181971.1 | São Paulo/Brazil | 2008 | |
| DENV-4 | AF326573.1 | Dominica | 2000 | |
