The Authors report a case of disseminated histoplasmosis in a patient during the course of non related kidney transplant. Besides the fungal infection detected by serology and histopathology, autopsy showed macro and micro-nodular hepatic cirrhosis, probably of viral etiology (B virus), hepatocarcinoma, lymphoid depletion of the spleen and transplant glomerulonephritis. After concerning literature review the Authors conclude that probably due to immunosuppressive therapy, the pulmonary lesions by endogenous reinfection were the first to appear under the form of a chronic pulmonary histoplasmosis.