Schistosoma mansoni: exacerbation of inflammatory granulomatous response in mice chronically infected and submitted to reinfection

Coelho, Paulo Marcos Z.; Toppa, Nivaldo H.; Mello, Rômulo T.; Feldmann, Juliana S.; Gonçalves, Robson

doi:10.1590/S0036-46651996000400012

Schistosoma mansoni; Exacerbation; Reinfection

BRIEF COMMUNICATION

Schistosoma mansoni: exacerbation of inflammatory granulomatous response in mice chronically infected and submitted to reinfection

Paulo Marcos Z. Coelho^I; Nivaldo H. Toppa^II; Rômulo T. Mello^III; Juliana S. Feldmann^IV; Robson Gonçalves^IV

^IFull Professor, Department of Parasitology, Federal University of Minas Gerais, Brazil

^IIAssistant Professor, Department of Pathological Anatomy, School of Medicine, Federal University of Minas Gerais, Brazil

^IIIAssistant Professor, Department of Clinical and Toxicological Analyses, School of Pharmacy, Federal University of Minas Gerais, Brazil

^IVFellow of CNPq, Brazil

^{Correspondence to} Correspondence to: Prof. Paulo Marcos Zech Coelho Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais Caixa Postal 486 30161-970 Belo Horizonte, MG, Brasil

Keywords:Schistosoma mansoni; Exacerbation/granuloma; Reinfection.

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ACKNOWLEDGEMENTS

We thank Mr. Alberto G. Santos, Miss Zenir de Souza, Miss Florence M. Rosa, Mr. José Carlos R. Santos and Mr. Atenágoras N. Silva for technical assistance; and Mrs. Vera de Paula Ribeiro for translating the manuscript. This work was supported in part by CNPq, FINEP, FAPEMIG, PRPq-UFMG, Brazil; WHO, Basle, Switzerland.

Recebido para publicação em 22/05/1996

Aceito para publicação em 22/08/1996

1. BARBOSA, M.A.; PELLEGRINO, J. & COELHO, P.M.Z. - Quantitative aspects of the migration and evolutive asynchronism of Schistosoma mansoni. Rev. Inst. Med. trop. S. Paulo, 20: 121-132, 1978.
2. BOROS, D.L. & LUKACS, N.W. - The role of eggs antigens, cytokines in granuloma formation in murine Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, 87: 75-80, 1992.
3. BYRAN, J.E. & VON LICHTENBERG, F. - Altered Schistosoma granuloma formation in nude mice. Amer. J. trop. Med. Hyg., 28: 944-956, 1977.
4. CHEEVER, A.W.; XY, Y.; MACEDONIA, J.G.; HIENEY, S. & SHER, A. - The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice. Mem. Inst. Oswaldo Cruz, 87: 81-85, 1992.
5. COELHO, P.M.Z.; RASO, P.; MELLO, R.T. & TOPPA, N.H. - Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment. Rev. Soc. bras. Med. trop., 27: 119-125, 1994.
6. DOMINGO, E.O.; COWAN, R.B.T. & WARREN, K.S. - The inhibition of granuloma formation around Schistosoma mansoni eggs. I - Immunosuppressive drugs. Amer. J. trop. Med. Hyg., 16: 284-292, 1967.
7. DOMINGO, E.O. & WARREN. K.S. - The inhibition of granuloma formation around Schistosoma mansoni eggs. II -Thymectomy. Amer. J. Path., 51: 757-767, 1967.
8. GRZYCH, J.M.; PEARCE, E.; CHEEVER, A. et al. - Egg deposition is the major stimulus for the production of TH2 cytokines in murine schistosomiasis mansoni. J. Immunol., 146: 1332, 1991.
9. HSÜ, C.K. - Immunopathology of schistosomiasis in athmymic mice. Nature (Lond.), 262: 397-398, 1976.
10. LUCAS, S.; MUSSALAM, R.; BAIN, J. et al. -The pathological effects of immunosuppression of Schistosoma mansoni infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with hidrocortisone acetate. Trans. roy. Soc. trop. Med. Hyg., 74: 633-643, 1980.
11. McLAREN, D.J. & SMITHERS, S.R. - The immune response to schistosomes in experimental hosts. In: ROLLINSON, D. & SIMPSON. A.J.G. The biology of schistosomes. From genes to latrines. London, Academic Press, 1987. p. 233-319.
12. MOSMANN, T.R. & COFFMANN, R.L. - Th1 and Th2: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol., 7: 145-173, 1989.
13. PERRIN, P.J. & PHILLIPS, S.M. - The molecular basis of granuloma formation in schistosomiasis. A T cell derived suppressor effect factor. J. Immunol., 143: 649-654, 1989.
14. PERROTO, J.L. & WARREN, K.S. - Inhibition of granuloma formation around.Schistosoma mansoni eggs. IV - X irradiation. Amer. J. Path., 56: 279-291, 1969.
15. RASO, P.; ROCHA, O.A.; PEREIRA, L.H. & TAFURI, W.L. - Efeito da timectomia neonatal na esquistossomose mansoni experimental. Rev. Soc. bras. Med. trop., 16: 112-121, 1983.
16. RASO, P.; COELHO, P.M.Z.; TOPPA, N.H. & MELLO, R.T. - Aspects of the granulomatous reaction in the liver of mice infected and reinfected with two different geographical strains of Schistosoma mansoni. Rev. Soc. bras. Med. trop., 27: 221-226, 1994.
16. STADECKER, M.J. & VILLANUEVA, P.O.F. - Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease. Immunol. today, 15: 571-574, 1994.

Correspondence to:

Prof. Paulo Marcos Zech Coelho

Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais

Caixa Postal 486

30161-970 Belo Horizonte, MG, Brasil

Publication Dates

Publication in this collection
22 Sept 2006
Date of issue
Aug 1996

History

Received
22 May 1996
Accepted
22 Aug 1996

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BARBOSA, M.A.; PELLEGRINO, J. & COELHO, P.M.Z. - Quantitative aspects of the migration and evolutive asynchronism of Schistosoma mansoni. Rev. Inst. Med. trop. S. Paulo, 20: 121-132, 1978.

[2] 2. BOROS, D.L. & LUKACS, N.W. - The role of eggs antigens, cytokines in granuloma formation in murine Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, 87: 75-80, 1992.

[3] 3. BYRAN, J.E. & VON LICHTENBERG, F. - Altered Schistosoma granuloma formation in nude mice. Amer. J. trop. Med. Hyg., 28: 944-956, 1977.

[4] 4. CHEEVER, A.W.; XY, Y.; MACEDONIA, J.G.; HIENEY, S. & SHER, A. - The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice. Mem. Inst. Oswaldo Cruz, 87: 81-85, 1992.

[5] 5. COELHO, P.M.Z.; RASO, P.; MELLO, R.T. & TOPPA, N.H. - Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment. Rev. Soc. bras. Med. trop., 27: 119-125, 1994.

[6] 6. DOMINGO, E.O.; COWAN, R.B.T. & WARREN, K.S. - The inhibition of granuloma formation around Schistosoma mansoni eggs. I - Immunosuppressive drugs. Amer. J. trop. Med. Hyg., 16: 284-292, 1967.

[7] 7. DOMINGO, E.O. & WARREN. K.S. - The inhibition of granuloma formation around Schistosoma mansoni eggs. II -Thymectomy. Amer. J. Path., 51: 757-767, 1967.

[8] 8. GRZYCH, J.M.; PEARCE, E.; CHEEVER, A. et al. - Egg deposition is the major stimulus for the production of TH2 cytokines in murine schistosomiasis mansoni. J. Immunol., 146: 1332, 1991.

[9] 9. HSÜ, C.K. - Immunopathology of schistosomiasis in athmymic mice. Nature (Lond.), 262: 397-398, 1976.

[10] 10. LUCAS, S.; MUSSALAM, R.; BAIN, J. et al. -The pathological effects of immunosuppression of Schistosoma mansoni infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with hidrocortisone acetate. Trans. roy. Soc. trop. Med. Hyg., 74: 633-643, 1980.

[11] 11. McLAREN, D.J. & SMITHERS, S.R. - The immune response to schistosomes in experimental hosts. In: ROLLINSON, D. & SIMPSON. A.J.G. The biology of schistosomes. From genes to latrines. London, Academic Press, 1987. p. 233-319.

[12] 12. MOSMANN, T.R. & COFFMANN, R.L. - Th1 and Th2: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol., 7: 145-173, 1989.

[13] 13. PERRIN, P.J. & PHILLIPS, S.M. - The molecular basis of granuloma formation in schistosomiasis. A T cell derived suppressor effect factor. J. Immunol., 143: 649-654, 1989.

[14] 14. PERROTO, J.L. & WARREN, K.S. - Inhibition of granuloma formation around.Schistosoma mansoni eggs. IV - X irradiation. Amer. J. Path., 56: 279-291, 1969.

[15] 15. RASO, P.; ROCHA, O.A.; PEREIRA, L.H. & TAFURI, W.L. - Efeito da timectomia neonatal na esquistossomose mansoni experimental. Rev. Soc. bras. Med. trop., 16: 112-121, 1983.

[16] 16. RASO, P.; COELHO, P.M.Z.; TOPPA, N.H. & MELLO, R.T. - Aspects of the granulomatous reaction in the liver of mice infected and reinfected with two different geographical strains of Schistosoma mansoni. Rev. Soc. bras. Med. trop., 27: 221-226, 1994.

[17] 16. STADECKER, M.J. & VILLANUEVA, P.O.F. - Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease. Immunol. today, 15: 571-574, 1994.